1.A Case of Acute Cholestatic Hepatitis Associated with Orlistat.
Doh Hyun KIM ; Eun Hee LEE ; Jae Chul HWANG ; Jai Hak JEUNG ; Do Hyun KIM ; Jae Youn CHEONG ; Sung Won CHO ; Young Bae KIM
The Korean Journal of Hepatology 2002;8(3):317-320
Orlistat(Xenical(R), Roche) is considered a safe and effective drug to treat obesity by reduced absorption of 30% digested fat. To date, no serious adverse effects affecting the liver have been published except a case of subacute hepatic failure leading to liver transplantation in a young women with moderate obesity treated with orlistat. We report a case of acute cholestatic hepatitis in a young woman with moderate obesity treated with orlistat: a 33-year-old female admitted for the evaluation of jaundice. Abdominal ultrasonography, ERCP, routine chemistry, viral markers, and a fine needle biopsy of liver were performed. Microscopic findings of the liver biopsy specimen were compatible with acute cholestatic hepatitis. After steroid therapy, liver function was improved.
Acute Disease
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Adult
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Anti-Obesity Agents/*adverse effects
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Cholestasis/*chemically induced/diagnosis
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English Abstract
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Female
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Hepatitis, Toxic/*diagnosis/etiology
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Human
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Lactones/*adverse effects
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Lipase/antagonists & inhibitors
2.A case of ticlopidine induced acute cholestatic hepatitis and pure red cell aplasia.
Ji Yeon LEE ; Eun Bum PARK ; Jae Hong AHN ; Sang Jun SUH ; Young Kul JUNG ; Ji Hoon KIM ; Bong Kyung SHIN ; Jin Hyuk YANG ; Jong Eun YEON ; Kwan Soo BYUN
The Korean Journal of Hepatology 2008;14(1):102-107
Ticlopidine inhibits platelet aggregation and provides beneficial secondary prevention of cerebrovascular and coronary artery disease. Frequently reported adverse effects of ticlopidine include diarrhea, nausea, and rash. However, to our knowledge, there are only a few published reports of the simultaneous occurrence of cholestatic hepatitis and pure red cell aplasia. Here we report a patient with simultaneous severe cholestatic hepatitis and pure red cell aplasia associated with ticlopidine. Although these adverse effects are rare, periodic hematological and liver function tests are recommended after starting ticlopidine.
Acute Disease
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Cholestasis/*chemically induced/diagnosis/etiology
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Female
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Hepatitis, Toxic/*diagnosis/pathology
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Humans
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Liver Function Tests
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Middle Aged
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Platelet Aggregation Inhibitors/*adverse effects
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Red-Cell Aplasia, Pure/*chemically induced/diagnosis/pathology
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Ticlopidine/*adverse effects
3.A case of amoxicillin-induced hepatocellular liver injury with bile-duct damage.
Ju Seung KIM ; Young Rock JANG ; Ji Won LEE ; Jin Yong KIM ; Young Kul JUNG ; Dong Hae CHUNG ; Oh Sang KWON ; Yun Soo KIM ; Duck Joo CHOI ; Ju Hyun KIM
The Korean Journal of Hepatology 2011;17(3):229-232
Amoxicillin, an antibiotic that is widely prescribed for various infections, is associated with a very low rate of drug-induced liver injury; hepatitis and cholestasis are rare complications. Here we present a case of a 39-year-old woman who was diagnosed with abdominal actinomycosis and received amoxicillin treatment. The patient displayed hepatocellular and bile-duct injury, in addition to elevated levels of liver enzymes. The patient was diagnosed with amoxicillin-induced cholestatic hepatitis. When amoxicillin was discontinued, the patient's symptoms improved and her liver enzyme levels reduced to near to the normal range.
Actinomycosis/drug therapy
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Adult
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Alanine Transaminase/blood
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Alkaline Phosphatase/blood
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Amoxicillin/*adverse effects
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Anti-Bacterial Agents/*adverse effects
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Aspartate Aminotransferases/blood
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Cholestasis/*chemically induced
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Drug-Induced Liver Injury/*diagnosis/etiology
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Female
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Humans
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Liver/enzymology
4.Drug rash with eosinophilia and systemic symptoms syndrome following cholestatic hepatitis A: a case report.
Jihyun AN ; Joo Ho LEE ; Hyojeong LEE ; Eunsil YU ; Dan Bi LEE ; Ju Hyun SHIM ; Sunyoung YOON ; Yumi LEE ; Soeun PARK ; Han Chu LEE
The Korean Journal of Hepatology 2012;18(1):84-88
Hepatitis A virus (HAV) infections occur predominantly in children, and are usually self-limiting. However, 75-95% of the infections in adults are symptomatic (mostly with jaundice), with the illness symptoms usually persisting for a few weeks. Atypical manifestations include relapsing hepatitis, prolonged cholestasis, and complications involving renal injury. Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a severe, drug-induced hypersensitivity reaction characterized by skin rash, fever, lymph-node enlargement, and internal organ involvement. We describe a 22-year-old male who presented with acute kidney injury and was diagnosed with prolonged cholestatic hepatitis A. The patient also developed DRESS syndrome due to antibiotic and/or antiviral treatment. To our knowledge, this is the first report of histopathologically confirmed DRESS syndrome due to antibiotic and/or antiviral treatment following HAV infection with cholestatic features and renal injury.
Acute Kidney Injury/diagnosis
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Anti-Bacterial Agents/*adverse effects/therapeutic use
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Cefotaxime/adverse effects/therapeutic use
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Cholestasis/complications/*diagnosis
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Cytomegalovirus/genetics
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Cytomegalovirus Infections/drug therapy/virology
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DNA, Viral/analysis
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Eosinophilia/etiology
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Exanthema/*chemically induced/pathology
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Ganciclovir/therapeutic use
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Hepatitis A/complications/*diagnosis/drug therapy
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Humans
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Hydrocortisone/therapeutic use
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Immunoglobulins/therapeutic use
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Male
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Syndrome
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Young Adult