1.A Case of Idiopathic Adulthood Ductopenia.
Byeong Chool PARK ; Seon Mee PARK ; Eun Young CHOI ; Hee Bok CHAE ; Se Jin YOON ; Rohyun SUNG ; Sung Koo LEE
The Korean Journal of Internal Medicine 2009;24(3):270-273
Idiopathic adulthood ductopenia (IAD) is a chronic cholestatic liver disease of unknown etiology characterized by adult onset, an absence of autoantibodies, inflammatory bowel disease, and a loss of interlobular bile ducts. In the present report, a case fulfilling the IAD criteria is described. A 19-year-old man was admitted to the hospital for persistent elevation of transaminases and alkaline phosphatase without clinical symptoms. Viral hepatitis markers and autoantibodies were absent. The patient had a normal extrahepatic biliary tree and had no evidence of inflammatory bowel disease. A liver biopsy specimen showed absence of interlobular bile ducts from 58% of the portal tracts. He was diagnosed with IAD and was treated with ursodeoxycholic acid.
Adult
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Cholestasis, Intrahepatic/*diagnosis/etiology/pathology
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Chronic Disease
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Humans
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Male
2.Triple-Tissue Sampling during Endoscopic Retrograde Cholangiopancreatography Increases the Overall Diagnostic Sensitivity for Cholangiocarcinoma.
Seung June LEE ; Yoon Suk LEE ; Min Geun LEE ; Sang Hyub LEE ; Eun SHIN ; Jin Hyeok HWANG
Gut and Liver 2014;8(6):669-673
BACKGROUND/AIMS: There are several methods for obtaining tissue samples to diagnose malignant biliary strictures during endoscopic retrograde cholangiopancreatography (ERCP). However, each method has only limited sensitivity. This study aimed to evaluate the diagnostic accuracy of a combined triple-tissue sampling (TTS) method (on-site bile aspiration cytology, brush cytology, and forceps biopsy). METHODS: We retrospectively reviewed 168 patients with suspicious malignant biliary strictures who underwent double-tissue sampling (DTS; n=121) or TTS (n=47) via ERCP at our institution from 2004 to 2011. RESULTS: Among the 168 patients reviewed, 117 patients (69.6%) were eventually diagnosed with malignancies. The diagnostic sensitivity for cancer was significantly higher in the TTS group than the DTS group (85.0% vs 64.9%, respectively; p=0.022). Furthermore, the combination of brush cytology and forceps biopsy was superior to the other method combinations in the DTS group. With respect to cancer type (cholangiocarcinoma vs noncholangiocarcinoma), interestingly, the diagnostic sensitivity was higher for cholangiocarcinoma in the TTS group than the DTS group (100% vs 69.4%, respectively; p<0.001) but not for the non-cholangiocarcinoma patients (57.1% vs 57.1%, respectively). CONCLUSIONS: TTS can provide an improved diagnostic accuracy in suspicious malignant biliary strictures, particularly for cholangiocarcinoma.
Aged
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Ampulla of Vater/*pathology
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Bile Duct Neoplasms/complications/diagnosis/pathology
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Bile Ducts, Intrahepatic/*pathology
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Biopsy/*methods
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Biopsy, Needle
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Carcinoma/complications/diagnosis/pathology
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Cholangiocarcinoma/complications/*diagnosis/pathology
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Cholangiopancreatography, Endoscopic Retrograde/*methods
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Cholestasis/etiology
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Common Bile Duct Neoplasms/complications/*diagnosis/pathology
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Female
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Humans
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Male
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Middle Aged
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Pancreatic Neoplasms/complications/*diagnosis/pathology
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Retrospective Studies
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Sensitivity and Specificity