2.A Case of Adenocarcinoma in situ of the Distal Common Bile Duct Diagnosed by Percutaneous Transhepatic Cholangioscopy.
Hyo Joon YANG ; Jai Hwan KIM ; Jae Young CHUN ; Su Jin KIM ; Sang Hyub LEE ; Haeryoung KIM ; Jin Hyeok HWANG
The Korean Journal of Internal Medicine 2012;27(2):211-215
Extrahepatic cholangiocarcinoma is often clinically challenging to diagnose. Even multidisciplinary approaches which include computed tomography, magnetic resonance imaging, and endoscopic retrograde cholangiography are unsatisfactory in some cases, especially with biliary stricture. Percutaneous transhepatic cholangioscopy (PTCS) with its direct visualization for biopsy appears to be a promising technique for detecting cholangiocarcinoma at an early stage. We report a case of adenocarcinoma in situ of the distal common bile duct (CBD) that was confirmed by PTCS. This case suggests the useful role of PTCS in the differential diagnosis of a distal CBD obstruction, particularly when other diagnostic modalities do not provide definitive information.
Carcinoma in Situ/complications/*diagnosis/pathology/surgery
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Cholangiocarcinoma/complications/*diagnosis/pathology/surgery
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Cholangiopancreatography, Endoscopic Retrograde
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Cholestasis, Extrahepatic/diagnosis/etiology
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Common Bile Duct/*pathology/surgery
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Common Bile Duct Neoplasms/complications/*diagnosis/pathology/surgery
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Constriction, Pathologic
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*Endoscopy, Digestive System
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Humans
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Male
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Middle Aged
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Pancreaticoduodenectomy
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Predictive Value of Tests
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Tomography, X-Ray Computed
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Treatment Outcome
3.Treatment of Malignant Biliary Obstruction with a PTFE-Covered Self-Expandable Nitinol Stent.
Young Min HAN ; Hyo Sung KWAK ; Gong Yong JIN ; Seung Ok LEE ; Gyung Ho CHUNG
Korean Journal of Radiology 2007;8(5):410-417
OBJECTIVE: We wanted to determine the technical and clinical efficacy of using a PTFE-covered self-expandable nitinol stent for the palliative treatment of malignant biliary obstruction. MATERIALS AND METHODS: Thirty-seven patients with common bile duct strictures caused by malignant disease were treated by placing a total of 37 nitinol PTFE stents. These stents were covered with PTFE with the exception of the last 5 mm at each end; the stent had an unconstrained diameter of 10 mm and a total length of 50-80 mm. The patient survival rate and stent patency rate were calculated by performing Kaplan-Meier survival analysis. The bilirubin, serum amylase and lipase levels before and after stent placement were measured and then compared using a Wilcoxon signed-rank test. The average follow-up duration was 27.9 weeks (range: 2-81 weeks). RESULTS: Placement was successful in all cases. Seventy-six percent of the patients (28/37) experienced adequate palliative drainage for the remainder of their lives. There were no immediate complications. Three patients demonstrated stent sludge occlusion that required PTBD (percutaneous transhepatic biliary drainage) irrigation. Two patients experienced delayed stent migration with stone formation at 7 and 27 weeks of follow-up, respectively. Stent insertion resulted in acute elevations of the amylase and lipase levels one day after stent insertion in 11 patients in spite of performing endoscopic sphincterotomy (4/6). The bilirubin levels were significantly reduced one week after stent insertion (p < 0.01). The 30-day mortality rate was 8% (3/37), and the survival rates were 49% and 27% at 20 and 50 weeks, respectively. The primary stent patency rates were 85%, and 78% at 20 and 50 weeks, respectively. CONCLUSION: The PTFE-covered self-expandable nitinol stent is safe to use with acceptable complication rates. This study is similar to the previous studies with regard to comparing the patency rates and survival rates.
Adenocarcinoma/*complications
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Aged
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Aged, 80 and over
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Alloys/adverse effects/*therapeutic use
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Cholestasis, Extrahepatic/etiology/*surgery
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Coated Materials, Biocompatible/*therapeutic use
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Common Bile Duct/radiography/surgery
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Digestive System Neoplasms/*complications
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Equipment Design
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Female
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Follow-Up Studies
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Humans
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Male
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Middle Aged
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Palliative Care/methods
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Pilot Projects
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Polytetrafluoroethylene/adverse effects/*therapeutic use
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Postoperative Complications/diagnosis/epidemiology
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Prospective Studies
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*Stents/adverse effects
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Survival Analysis
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Treatment Outcome