1.Primary Sclerosing Cholangitis.
The Korean Journal of Hepatology 2004;10(2):154-157
No abstract available.
Adult
;
Cholangitis, Sclerosing/*diagnosis/pathology
;
Diagnosis, Differential
;
Humans
;
Liver Cirrhosis, Biliary/diagnosis
;
Male
2.Drug-induced bile duct injury: progress and challenges.
Chinese Journal of Hepatology 2023;31(4):339-344
Drug-induced bile duct injury is a specific kind of drug-induced liver injury that has two main pathological types, namely ductopenia, or vanishing bile duct syndrome, and secondary sclerosing cholangitis. However, in recent years, the reports of new drugs that cause bile duct injury have been constantly increasing, and these drugs have different clinicopathological features and a novel pathogenesis. Therefore, this paper summarizes and analyzes the progress and challenges in the etiology, pathogenesis, diagnosis and treatment, and other aspects of drug-induced bile duct injury.
Humans
;
Cholestasis/chemically induced*
;
Cholangitis, Sclerosing/diagnosis*
;
Chemical and Drug Induced Liver Injury/pathology*
;
Bile Ducts/pathology*
5.IgG4-Associated Cholangitis Can Mimic Hilar Cholangiocarcinoma.
Victor M ZAYDFUDIM ; Andrew Y WANG ; Eduard E DE LANGE ; Zimin ZHAO ; Christopher A MOSKALUK ; Todd W BAUER ; Reid B ADAMS
Gut and Liver 2015;9(4):556-560
IgG4-associated cholangitis can mimic hilar cholangiocarcinoma. Previously reported patients with IgG4-associated cholangitis mimicking cholangiocarcinoma had elevated serum IgG4 levels and long-segment biliary strictures. However, in the absence of other diagnostic criteria for malignancy, IgG4-associated cholangitis should remain a consideration among patients with normal serum IgG4 and a hilar mass suspicious for cholangiocarcinoma. The presence of a hilar mass and a malignant-appearing biliary stricture in two patients with normal serum IgG4 prompted further evaluation and subsequent concomitant liver and bile duct resection and reconstruction. The diagnosis of IgG4-associated cholangitis was established during the pathologic evaluation of the resected specimens. IgG4-associated cholangitis is a known imitator of hilar cholangiocarcinoma and should be considered in the differential diagnosis even among serologically IgG4-negative patients with a hilar mass prior to operative resection.
Aged
;
Bile Ducts/pathology/surgery
;
Cholangitis/blood/*diagnosis
;
Diagnosis, Differential
;
Humans
;
Immunoglobulin G/*blood
;
Klatskin Tumor/blood/*diagnosis
;
Liver/pathology/surgery
;
Male
6.Portal inflammation and bile ductular proliferation.
Chinese Journal of Pathology 2006;35(11):695-696
Antigens, CD1
;
metabolism
;
Child, Preschool
;
Cholangitis, Sclerosing
;
diagnosis
;
etiology
;
metabolism
;
Diagnosis, Differential
;
Female
;
Histiocytosis, Langerhans-Cell
;
complications
;
metabolism
;
pathology
;
Humans
;
Immunohistochemistry
;
Liver
;
metabolism
;
pathology
;
S100 Proteins
;
metabolism
7.Sclerosing Cholangitis: Clinicopathologic Features, Imaging Spectrum, and Systemic Approach to Differential Diagnosis.
Nieun SEO ; So Yeon KIM ; Seung Soo LEE ; Jae Ho BYUN ; Jin Hee KIM ; Hyoung Jung KIM ; Moon Gyu LEE
Korean Journal of Radiology 2016;17(1):25-38
Sclerosing cholangitis is a spectrum of chronic progressive cholestatic liver disease characterized by inflammation, fibrosis, and stricture of the bile ducts, which can be classified as primary and secondary sclerosing cholangitis. Primary sclerosing cholangitis is a chronic progressive liver disease of unknown cause. On the other hand, secondary sclerosing cholangitis has identifiable causes that include immunoglobulin G4-related sclerosing disease, recurrent pyogenic cholangitis, ischemic cholangitis, acquired immunodeficiency syndrome-related cholangitis, and eosinophilic cholangitis. In this review, we suggest a systemic approach to the differential diagnosis of sclerosing cholangitis based on the clinical and laboratory findings, as well as the typical imaging features on computed tomography and magnetic resonance (MR) imaging with MR cholangiography. Familiarity with various etiologies of sclerosing cholangitis and awareness of their typical clinical and imaging findings are essential for an accurate diagnosis and appropriate management.
Adult
;
Aged
;
Aged, 80 and over
;
Bile Ducts/*pathology
;
Cholangiography/*methods
;
Cholangitis/diagnosis/*pathology
;
Cholangitis, Sclerosing/*diagnosis/pathology
;
Cholestasis/diagnosis/*pathology
;
Chronic Disease
;
Constriction, Pathologic/diagnosis
;
Diagnosis, Differential
;
Female
;
Humans
;
Immunoglobulin G/immunology
;
Liver/pathology
;
Magnetic Resonance Imaging/methods
;
Male
;
Middle Aged
;
Tomography, X-Ray Computed/methods
8.Comparison of Clinical Findings between Autoimmune Pancreatitis with Bile Duct Involvement and Primary Sclerosing Cholangitis.
Ja Young KIM ; Myung Hwan KIM ; Ji Hoon JUNG ; Ju Hyung SONG ; Hyoung Chul OH ; Seung Hyun KWON ; Tae Yoon LEE ; Sang Soo LEE ; Dong Wan SEO ; Sung Koo LEE
The Korean Journal of Gastroenterology 2006;48(2):104-111
BACKGOUND/AIMS: The involvement of bile ducts is frequently reported in autoimmune pancreatitis (AIP), which seem to have similar features to primary sclerosing cholangitis (PSC). Recent systematic comparative studies about these diseases are rare in Korea. METHODS: We retrospectively analyzed 26 patients with AIP with bile duct involvement and 30 patients with classic PSC who were diagnosed during the last decade. RESULTS: The mean age of patients was significantly higher in AIP than PSC at the time of diagnosis. There was a preponderance of men in both group, which was more prominent in AIP. The most common symptom in patients with AIP was jaundice, but PSC patients usually visited hospitals due to incidentally detected abnormal liver function tests. Most (26/31) of AIP had bile duct involvement. All of these patients showed narrowing of intrapancreatic common bile ducts and one patient exhibited hilar involvement as well. About 80% of PSC had both intra- and extrahepatic ducts involvement, and the characteristic features involve multifocal strictures. AIP patients showed improvement with steroid treatment, however, most PSC patients showed clinical deterioration. CONCLUSIONS: The clinical and cholangiographic findings of patients with AIP and PSC have many different characteristics. Therefore, further study of two diseases is required for the proper diagnosis and management.
Autoimmune Diseases/*diagnosis/pathology/radiography
;
Bile Ducts/pathology
;
*Cholangiography
;
Cholangiopancreatography, Endoscopic Retrograde
;
Cholangitis, Sclerosing/*diagnosis/pathology/radiography
;
Diagnosis, Differential
;
Female
;
Humans
;
Immunoglobulins/blood
;
Male
;
Pancreatitis/*diagnosis/*immunology/pathology
;
Retrospective Studies
;
Sex Factors
9.A Case of Congenital Hepatic Fibrosis Presented with Recurrent Acute Cholangitis.
Shin Young LEE ; Hye Jin JOO ; Young Shim CHO ; Won Joong JEON ; Hee Bok CHAE ; Seon Mee PARK ; Sei Jin YOUN ; Rohyun SUNG
The Korean Journal of Gastroenterology 2009;54(6):404-408
Acute cholangitis usually develops in congenital hepatic fibrosis (CHF), accompanied by cystic dilated bile ducts. However, it can also develop in simple CHF and may lead to critical course. A 30-year old man presented with recurrent acute cholangitis without bile duct dilatation. He visited the hospital for febrile sense and abdominal pain in the right upper quadrant. He had been admitted several times for hepatosplenomegaly and cholangitis since childhood and received a liver biopsy 15 years ago. Abdominal computed tomography (CT) and endoscopic retrograde cholangiopancreatography (ERCP) revealed hepatosplenomegaly and a mildly dilated bile duct without stones or biliary cysts. His condition improved after conservative treatment. However, during a two-month follow up period, the patient experienced three episodes of acute cholangitis. A liver biopsy was performed and showed periportal fibrosis and intrahepatic ductular dysplasia, characteristics of congenital hepatic fibrosis. The periportal fibrosis and the infiltration of inflammatory cells were aggravated compared to 15 years ago. There was no evidence of hepatic cirrhosis. He was diagnosed with congenital hepatic fibrosis with recurrent acute cholangitis without intrahepatic duct dilatation, and conservatively treated with antibiotics.
Acute Disease
;
Adult
;
Cholangiopancreatography, Endoscopic Retrograde
;
Cholangitis/complications/*diagnosis
;
Humans
;
Liver Cirrhosis/complications/*congenital/pathology
;
Male
;
Recurrence
;
Tomography, X-Ray Computed
10.A Case of Sclerosing Cholangitis Showing Response to Prednisolone.
Yo Sig SHIN ; Yong Seok JANG ; Min Kyoung KANG ; Byoung Kuk JANG ; Kyung Sik PARK ; Jae Seok HWANG ; Jung Hyeok KWON ; Yu Na KANG
The Korean Journal of Gastroenterology 2007;50(6):402-406
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by progressive fibrosis and destruction of intra- and extrahepatic bile ducts resulting in hepatic failure and death. Only the liver transplantation is the possible treatment for patients to survive. There has been a few reports that steroid is an effective treatment in autoimmune variant sclerosing cholangitis, which is thought to be a familial diseases with different etiology, and steroid responsive biliary strictures be named as immunoglobulin G4 (IgG4)-associated cholangitis (IAC). There is no reliable data regarding effective steroid treatment in autoimmue variant sclerosing cholangitis in Korea. We report a case of 32-year-old male with sclerosing cholangitis, who was diagnosed by endoscopic retrograde cholangiopancreatography (ERCP) and liver biopsy, showing favorable response to prednisolone therapy.
Adult
;
Anti-Inflammatory Agents/*therapeutic use
;
Cholangiopancreatography, Endoscopic Retrograde/methods
;
Cholangitis, Sclerosing/*diagnosis/pathology
;
Humans
;
Male
;
Prednisolone/*therapeutic use
;
Treatment Outcome