1.A case of mucocele of the sphenoid sinus causing complete visual loss.
Young Min KIM ; Young Min PARK ; Young Cho KOH
Korean Journal of Otolaryngology - Head and Neck Surgery 1992;35(4):590-595
No abstract available.
Mucocele*
;
Sphenoid Sinus*
2.Lymphocyte subsets in schizophrenic patients.
Gyung Joon PARK ; Young Cho CHUNG
Journal of Korean Neuropsychiatric Association 1991;30(2):263-270
No abstract available.
Humans
;
Lymphocyte Subsets*
;
Lymphocytes*
3.Solitary Morphea Profunda with Incidental Acantholysis.
Young Min PARK ; Sang Hyun CHO ; Baik Kee CHO
Annals of Dermatology 1999;11(2):78-81
Solitary morphea profunda is a rare form of scleroderma, characterized clinically by a solitary sclerotic plaque, and histologically by marked dermal and subcutaneous fibrosis with an inflammatory infiltrate. We describe another case of this entity presented with an ulcerative, indurated plaque on the left iliac crest, which histologically revealed a focal incidental acantholysis in the overlying epidermis and a marked eosinophilic infiltration through the dermis to the sub-cutaneous tissue.
Acantholysis*
;
Dermis
;
Eosinophils
;
Epidermis
;
Fibrosis
;
Scleroderma, Localized*
;
Ulcer
4.The effect of transforming growth factor-beta on the expression of CD8 in the CTLL-2 cell line.
Soo Young PARK ; Yoon Hae CHANG ; Young Joo CHO
Journal of Asthma, Allergy and Clinical Immunology 2000;20(1):92-98
BACKGROUND: Transforming growth factor-beta(TGF-beta) has multiple regulatory effects on cells of the immune system, and it has been suggested that differentiation of lymphoid cells is influenced by low concentra tions of this cytokine. OBJECTIVES: The aim or this study was to investigate the role of TGF-beta in regulation of T cell growth and differentiation, and to compare this effect with that of other cell signals known to be important in T cell ontogeny. METHODS: We used the CTLL-2 cell line in the presence of IL-2. Surface phenotype expression was analysed to see whether these cells could be switched to the other subtype of cells. RESULT: Treatment of CTLL-2 cells with TGF-beta resulted in dose dependent growth inhibition and morphological changes. Curing routine passage, less than 5% of cells were CD8alpha positive, whereas 38% of cells expressed CD8alpha when treated with IL-2 plus TGF-beta. However, TPA plus calcium ionophore, IFN-gamma, or TNF-alpha caused no significant changes in the proportion of CD8 cells. CONCLUSION: Our results show that this experiment can be a useful model for investigating CD8 precursor potentials in populations of CD4-CD8-(double negative) cells, and such a model may offer a way to study the molecular regulation of CD8 gene expression.
Calcium
;
Cell Line*
;
Gene Expression
;
Immune System
;
Interleukin-2
;
Lymphocytes
;
Phenotype
;
Transforming Growth Factor beta
;
Tumor Necrosis Factor-alpha
5.A case of organic hallucinosis with left temporal lobe atrophy.
Se Hyun PARK ; Young Ho LEE ; Young Cho CHUNG
Journal of Korean Neuropsychiatric Association 1993;32(2):273-278
No abstract available.
Atrophy*
;
Temporal Lobe*
6.Brain MRI Findings for the Patient with the Late Onset Schizophrenia: Comparison among Patients with the Early Onset Schizophrenia, Progressive Schizophrenia, Senile Dementia and Controls.
Doo Sung PARK ; Young Ho LEE ; Young Hee CHOI ; Young Soo PARK ; Young Cho CHUNG
Journal of the Korean Society of Biological Psychiatry 1997;4(1):74-83
With increasing tendency of incidence and interest for the late onset schzophrenia, concerns about whether this disorder is etiologically or phenomenogically distinctive entity or not have increased also. To clarify the disease entity of the late onset schzophrenia and the role of structural brain changes in its etiology, authors tried to prove following hypothesis : Are there any evidences of structural brain changes in the late-onset schizophrenia? ; If present, are they not different from those of the early-onset schizophrenia or progressive schizophrenia? ; And are they not different from those of senile dementia? Subjects were 6 patients with the late-onset schizophrenia, 6 patients with the early-onset schizophrenia, 6 patients with progressive schizophrenia, 6 patients with Alzheimer's dementia, and 6 controls. We measured regions of interest of the magnetic resonance images by computer assisted planimetry using the AutoCad and digitizer. Our study results may suggest that the third ventricular enlargement and a reversal of normal difference between left and right temporal lobe and left-right difference in posterior lateral ventricle are common brain pathology for all type of schizophrenia including the late onset schzophrenia. And also suggest that brain structural changes of the late onset schizophrenia are related with neurodevelopmental abnormality rather than degenerative change.
Alzheimer Disease*
;
Brain Diseases
;
Brain*
;
Dementia
;
Humans
;
Incidence
;
Lateral Ventricles
;
Magnetic Resonance Imaging*
;
Schizophrenia*
;
Temporal Lobe
7.A clinical study in the diagnostic efficacy of mammography todetecty the breast carcinoma.
Jong Whan CHO ; Seung Hoi PARK ; Hye Soon PARK ; Hong Jun CHO ; Young Sik KIM
Journal of the Korean Academy of Family Medicine 1991;12(11):14-20
No abstract available.
Breast Neoplasms*
;
Breast*
;
Mammography*
8.A Case of Diffuse Biphasic Cutaneous Amyloidosis.
Young Min PARK ; Koo Seog CHAE ; Sang Hyun CHO ; Baik Kee CHO ; Chan Kum PARK
Annals of Dermatology 1997;9(4):281-285
We described a case of diffuse biphasic cutaneous amyloidosis, a unique form of localized cutaneous amyloidosis. A 41-year-old man has gradually developed a lichenoid papular and a grouped spotted pigmented macular eruption on the trunk and upper extremities over the past 15 years. Histopathologic examination revealed that amyloid deposits were present in the papillary dermis. It was confirmed by Congo red staining, immunohistochemistry and electron microscopy. There was no evidence of systemic amyloidosis.
Adult
;
Amyloidosis*
;
Congo Red
;
Dermis
;
Humans
;
Immunohistochemistry
;
Microscopy, Electron
;
Plaque, Amyloid
;
Upper Extremity
9.Research on the frequency of Terry's nail in the medical inpatients with chronic illnesses.
Kwang Young PARK ; Sang Won KIM ; Jong Soo CHO
Korean Journal of Dermatology 1992;30(6):864-870
Terrys nail(TN) might be causally associated with cirrhosis or other disorders, but his criteria have been proved to be inadequate reflection of systcmic disorders. Modified criteria of Holzberg and Walker were introduced in TN examination in 1984. Using these criteria, fingernails were studied in 444 medical inpatients with chronic systemic diseases at Taegu Catholic Hospital from March 1991 to March 1992. There were 136(30.6%) patients with TN and 308(69.4%) patients without TN, respectively. Ninety-three patients with TN showed a signifiart association with cirrosis(49/86, 57%, p<0.01 by the x-test), congestive heart failure 18/35, 515, p<0.05), and diabetes mellitus(25/51, 49%, p<0.05), and otherwise not;ignificantly associated with chronic renal failure(19%), and cancer(18%). Male and female patients with TN were affected about equally. Age distribution in The patients with TN showed 35(25.8%) the age group from twenty to fortynine and 101(74.2%) in the age group from fifty and above with a mean age of 57.3+14.0, whereas the patients without TN had 178(57.8%), and 130(42.2%), with 47.4+16.9, respectively. The greater part was distributed in the older group(p<0.001 by student t-test), suggestive of an increased risk in older group. The average number of nails affected per patient was tending to be higher in frequency close to the thumb, with an equal frequency in six. Thirty-nine patients(28.7%) had all nails affected. The distal band with was 0.5 to 3.0mm averaging 1.0+0.5mm with no difference, in sex. The distal band was pink in 43(31.6%) of the 136 patients with TN, brown in 62(45.6%) and intermediate in color in 13(22,8%). The results of routine laboratory test such as hemogram, eiythrocyte sedimenation rate, liver enzyme, triglyceride, protein, albumin, blood urea nitrogen and creatinine were statistically insignificant between the patients with and without TN.
Age Distribution
;
Blood Urea Nitrogen
;
Chronic Disease*
;
Creatinine
;
Daegu
;
Female
;
Fibrosis
;
Heart Failure
;
Humans
;
Inpatients*
;
Liver
;
Male
;
Nails
;
Thumb
;
Triglycerides
10.A case of disseminated superficial porokeratosis in immunosuppressed kidney transplant recipient.
Young Ho CHO ; Seung Kyung HANN ; Yoon Kee PARK
Korean Journal of Dermatology 1992;30(4):539-542
Porokeratosis is an uncommon autosomally dominant inher ted disorder. Clinically, it is characterized by nonhealing plaques that develop most comnorly on the limbs. We report a case of disseminated superficial porokeratosis in immunosuppre sed kidney transplant recipient. An abrupt and extensive eruption of porokeratosis was observed in a 46-year-old man 7 months after renal transplantation, while being treated with cyclosporin A and prednisone. The histological features were essentially the same as the typical cornoid lamella. Immunosuppression may exacerbate or initiate the developm nt of porokeratosis in patients predisposed to alterations of cutaneous growth dynamics.
Cyclosporine
;
Extremities
;
Humans
;
Immunosuppression
;
Kidney Transplantation
;
Kidney*
;
Middle Aged
;
Porokeratosis*
;
Prednisone
;
Transplantation*