Lipocortin represents a family of similar Ca++ depentent phospholipid-binding proteins capable of blocking the activity of phospholipase A2 (PLA2) in vitro. Generally, these proteins are believed to inhibit the release of arachidonic acid from photopholipids and the formation of lipid mediators such as prostaglandin, leukotriene, and platelet activating factor. Lipocortin 1, initially identified as a glucocorticoid- responsive protein in macrophages and neutrophils has been implicated in transmembrane signal transduction during growth factor-mediated cell proliferation and transformation. To define the synthesis and its regulation, we investigated the expression of lipocortin 1 in both the mRNA and protein level in U937 cell line in the presence of several differentiation factors. The results were as follows. 1. The expression of lipocortin 1 and its mRNA was increased during TPA-induced differentiation of U937 cells to maximum of 2-fold and 5-fold respectively. Both the protein and mRNA levels decreased after 48 hours. 2. With the treatment with IFN-gamma, the expression of CD16 was increased. However, the protein and mRNA levels of lipocortin 1 were, not changed significantly. 3. Neither the dexamethasone or hydrocortisone have any effects on the expression of lipocortin 1 in both TPA-differentiated and undifferentiated U937 cells. The results from this study would give a light on defining the functional role of lipocortin 1 in macro-moncycle cell lineage and possibly some informative clues for the pathogenic mechanisms of the inflammatory diseases.
Annexin A1* ; Annexins* ; Arachidonic Acid ; Cell Lineage ; Cell Proliferation ; Dexamethasone ; Humans ; Hydrocortisone ; Macrophages ; Neutrophils ; Phospholipases A2 ; Platelet Activating Factor ; RNA, Messenger ; Signal Transduction ; U937 Cells*

No abstract available.
Mitral Valve*

No abstract available.

No abstract available.
Urticaria*

Objectives: This study compares and analyzes the effects of objective body mass index (BMI) and subjective body image on self-perceived oral health among Korean adults based on sex differences. Methods: Raw data were obtained from the 7th (2016-2018), 8th (2019), and 9th (2022) Korea National Health and Nutrition Examination Surveys. The study included 24,817 adults, with objective body type and subjective body image as the independent variables and self-perceived oral health status as the dependent variable. The results were analyzed by sex using complex sample logistic regression analysis with IBM SPSS Statistics. Results: An analysis of the impact of objective body type on poor self-perceived oral health status showed no significant difference for males, whereas the odds ratio was significant for females, with objective obesity at 1.167 (P<0.001). An analysis of the effect of subjective body image on poor self-perceived oral health status revealed that the odds ratio was significant for males with subjective obesity (OR 1.482, P<0.001). For females, the odds ratio was 1.225 for subjective overweight and 1.379 for subjective obesity, indicating that females were significantly more likely to perceive their oral health as poor (P<0.001). Conclusions Both males and females were more influenced by subjective body image than objective body type, and females were more sensitive than males to the impact of body type on their self-perceived oral health status. Although males were generally less sensitive about their body type, they were more likely than females to perceive their oral health negatively.

Objectives: This study compares and analyzes the effects of objective body mass index (BMI) and subjective body image on self-perceived oral health among Korean adults based on sex differences. Methods: Raw data were obtained from the 7th (2016-2018), 8th (2019), and 9th (2022) Korea National Health and Nutrition Examination Surveys. The study included 24,817 adults, with objective body type and subjective body image as the independent variables and self-perceived oral health status as the dependent variable. The results were analyzed by sex using complex sample logistic regression analysis with IBM SPSS Statistics. Results: An analysis of the impact of objective body type on poor self-perceived oral health status showed no significant difference for males, whereas the odds ratio was significant for females, with objective obesity at 1.167 (P<0.001). An analysis of the effect of subjective body image on poor self-perceived oral health status revealed that the odds ratio was significant for males with subjective obesity (OR 1.482, P<0.001). For females, the odds ratio was 1.225 for subjective overweight and 1.379 for subjective obesity, indicating that females were significantly more likely to perceive their oral health as poor (P<0.001). Conclusions Both males and females were more influenced by subjective body image than objective body type, and females were more sensitive than males to the impact of body type on their self-perceived oral health status. Although males were generally less sensitive about their body type, they were more likely than females to perceive their oral health negatively.

Objectives: This study compares and analyzes the effects of objective body mass index (BMI) and subjective body image on self-perceived oral health among Korean adults based on sex differences. Methods: Raw data were obtained from the 7th (2016-2018), 8th (2019), and 9th (2022) Korea National Health and Nutrition Examination Surveys. The study included 24,817 adults, with objective body type and subjective body image as the independent variables and self-perceived oral health status as the dependent variable. The results were analyzed by sex using complex sample logistic regression analysis with IBM SPSS Statistics. Results: An analysis of the impact of objective body type on poor self-perceived oral health status showed no significant difference for males, whereas the odds ratio was significant for females, with objective obesity at 1.167 (P<0.001). An analysis of the effect of subjective body image on poor self-perceived oral health status revealed that the odds ratio was significant for males with subjective obesity (OR 1.482, P<0.001). For females, the odds ratio was 1.225 for subjective overweight and 1.379 for subjective obesity, indicating that females were significantly more likely to perceive their oral health as poor (P<0.001). Conclusions Both males and females were more influenced by subjective body image than objective body type, and females were more sensitive than males to the impact of body type on their self-perceived oral health status. Although males were generally less sensitive about their body type, they were more likely than females to perceive their oral health negatively.

Objectives: This study compares and analyzes the effects of objective body mass index (BMI) and subjective body image on self-perceived oral health among Korean adults based on sex differences. Methods: Raw data were obtained from the 7th (2016-2018), 8th (2019), and 9th (2022) Korea National Health and Nutrition Examination Surveys. The study included 24,817 adults, with objective body type and subjective body image as the independent variables and self-perceived oral health status as the dependent variable. The results were analyzed by sex using complex sample logistic regression analysis with IBM SPSS Statistics. Results: An analysis of the impact of objective body type on poor self-perceived oral health status showed no significant difference for males, whereas the odds ratio was significant for females, with objective obesity at 1.167 (P<0.001). An analysis of the effect of subjective body image on poor self-perceived oral health status revealed that the odds ratio was significant for males with subjective obesity (OR 1.482, P<0.001). For females, the odds ratio was 1.225 for subjective overweight and 1.379 for subjective obesity, indicating that females were significantly more likely to perceive their oral health as poor (P<0.001). Conclusions Both males and females were more influenced by subjective body image than objective body type, and females were more sensitive than males to the impact of body type on their self-perceived oral health status. Although males were generally less sensitive about their body type, they were more likely than females to perceive their oral health negatively.

BACKGROUND: Microdeletion syndromes not detectable by conventional cytogenetic analysis have been reported to occur in approximately 5% of patients with unexplained mental retardation (MR). Therefore, it is essential to ensure that patients with MR are screened for these microdeletion syndromes. Mental retardation syndrome multiplex ligation-dependent probe amplification (MRS-MLPA) is a new technique for measuring sequence dosages that allows for the detection of copy number changes of several microdeletion syndromes (1p36 deletion syndrome, Williams syndrome, Smith-Magenis syndrome, Miller-Dieker syndrome, DiGeorge syndrome, Prader-Willi/Angelman syndrome, Alagille syndrome, Saethre-Chotzen syndrome, and Sotos syndrome) to be processed simultaneously, thus significantly reducing the amount of laboratory work. METHODS: We assessed the performance of MLPA (MRC-Holland, The Netherlands) for the detection of microdeletion syndromes by comparing the results with those generated using FISH assays. MLPA analysis was carried out on 12 patients with microdeletion confirmed by FISH (three DiGeorge syndrome, four Williams syndrome, four Prader-Willi syndrome, and one Miller-Dieker syndrome). RESULTS: The results of MLPA analysis showed a complete concordance with FISH in 12 patients with microdeletion syndromes. CONCLUSIONS: On the basis of these results, we conclude that MLPA is an accurate, reliable, and cost-effective alternative to FISH in the screening for microdeletion syndromes.
*Chromosome Deletion ; Classical Lissencephalies and Subcortical Band Heterotopias/genetics ; DiGeorge Syndrome/genetics ; Humans ; In Situ Hybridization, Fluorescence/*methods ; Laboratories, Hospital ; Mental Retardation/*diagnosis/genetics ; Nucleic Acid Amplification Techniques/*methods ; Prader-Willi Syndrome/genetics ; Williams Syndrome/genetics

Psoriasis is a multi-factorial disease with various clinical manifestations. We present a case of unilateral psoriasis associated with ipsilateral lymphedema that developed after mastectomy for breast cancer. A 42-year-old Korean woman was referred to our clinic with a 1-month history of multiple erythematous scaly patches on the right arm, back, and breast and was diagnosed with psoriasis by a skin biopsy. Three years previously, she had been diagnosed with breast cancer (T1N2), underwent a right quadrantectomy and axillary lymph node dissection, and completed adjuvant chemotherapy followed by high-dose adjuvant radiotherapy. She had started rehabilitation therapy on the right arm for secondary lymphedema 30 months previously. Because of the long interval between radiation and psoriasis, we speculated that changes in the local milieu caused by the lymphedema might be a causative factor. We hereby report a rare case of unilateral psoriasis following post-mastectomy lymphedema.
Adult ; Arm ; Biopsy ; Breast ; Breast Neoplasms ; Chemotherapy, Adjuvant ; Female ; Humans ; Lymph Node Excision ; Lymphedema ; Mastectomy ; Psoriasis ; Radiotherapy, Adjuvant ; Skin