The chlorpropamid (1) is an antidiabetic drug synthetized from chlorobenzene (2) in five steps through intermediates p-clorobenzenesulfonyl chloride (3), calcium p-chlorobenzene sulfonyl cyanamide (6), p-clorobenzenesulfonyl cyanamide (7), p-clorobenzenesulfonyl urea (8) and then the compound 8 was condensated with n-propylamine. The product have melting point, Rf, IR spectral data that suitable with to the chlopropamid extracted from Novopropamid tablet of Canada.
Chlorpropamide ; Methods

We report three cases of Diabetes insipidus which charactrized by the polyuria and polydipsia. All of the three cases well controlled with oral addministration of chlorpropamide. Two cases were idiopathic and the other was suspected pituitary tumor. A briet review of literature was made.
Chlorpropamide ; Diabetes Insipidus* ; Pituitary Neoplasms ; Polydipsia ; Polyuria

We report a case of a photosensitivity reaction in a 76-year-old inale induced by chlorpropamide ingestion. The patient had erythematous scaly patches on the sur. -exposed areas, A phototest revealed the decreased minimal erythemal dose(MED) to UVA(5J/cm). A photopatch test and photo-scartch test with 1% chlorpropamide ointment and 0.1% chlorpropamic!e .olution were all negative. An oral provocation test was performed, which showed a positive result with marked decrease of MED to UVA (5J/cm). After the cessation of chlorpropamide, his skin lesions were improved markedly with complete loss of photosensitivity. Macular hypopigmentations (leukcme.anoderma) appeared on the previous erythematous patchy ereas, but disappeared during the follow-up period.
Aged ; Chlorpropamide ; Eating ; Follow-Up Studies ; Humans ; Skin

BACKGROUND: Whether blood glucose levels may change the regulation of aquaporin(AQP) water channels in the kidney was investigated. METHODS: Male Sprague-Dawley rats were treated with chlorpropamide(40 mg/100 g body weight per day, per oral, for 7 days), and their expression of AQP1-3 and type VI adenylyl cyclase proteins was determined in the kidney. RESULTS: Following the treatment with chlorpropamide, the blood glucose level was significantly decreased compared with that in the control(64+/-8 vs 106+/-7 mg/dL, n=6 each, p < 0.01). Accordingly, the expression of AQP2 proteins was decreased in the cortex, outer medulla, and inner medulla. The AQP2 targeting was not significantly altered, as evidenced by parallel decreases of its expression in the membrane and the cytoplasmic fractions. No significant changes were observed in the expression of either AQP1 or of AQP3. The protein expression of type VI adenylyl cyclase was not significantly altered. CONCLUSION: These results suggest that hypoglycemia attenuates the expression of AQP2 water channels in the kidney.
Adenylyl Cyclases ; Animals ; Aquaporin 2* ; Aquaporins* ; Blood Glucose ; Body Weight ; Chlorpropamide* ; Cytoplasm ; Humans ; Hypoglycemia ; Kidney* ; Male ; Membranes ; Rats* ; Rats, Sprague-Dawley

Clinical review of 5 pediatric diabetes insipidus, who have been admitted and treated at Dept. of Pediatric in Chungnam University Hospital from Aug. 1974 to May 1979, were summarized as follows: 1) The common complaints were polyuria and polydipsia, and anorexia, general weakness, poor visual acuity, vomiting, and headache were associated occasionally. 2) Male to female ratio was 3:2, the age distribution was between 4 to 13 years old. 3) The duration which was from onset to visiting hospital was betwen 5 months to 13 months. 4) Etiologic causes were 2 cases of idiopathic, 1 of pinealoma, 1 of head trauma, and 1 of nephrogenic origin.5) Urine specific gravity was below 1.004 in all cases, and the amount of urine output per day was 4.8l to 5.9l. 6) Hypernatremia was observed in nephrogenic case but others were within normal limits. 7) On simple skull X-ray, calcification was seen in pinealoma which was displaced upward and backed, and it was confirmed by C-T scan. 8) Chlorpropamide was effective on idiopathic and traumatic origin but there was no response on nephrogenic origin.
Adolescent ; Age Distribution ; Anorexia ; Child* ; Chlorpropamide ; Chungcheongnam-do ; Craniocerebral Trauma ; Diabetes Insipidus* ; Female ; Headache ; Humans ; Hypernatremia ; Male ; Pinealoma ; Polydipsia ; Polyuria ; Skull ; Specific Gravity ; Visual Acuity ; Vomiting

OBJECTS: It has been reported that the incidence of tardive dyskinesia(TD), the remarkable abnormal involuntary movement, was higher in the schizophrenics with high blood sugar levels and that TD had been improved by small amount of insulin-injection for 90 days. And also it was generally known that the blood lipids were higher in the schizophrenics with tardive dyskinesia. Thus, we tried to replicate the correlations of abnormal involuntary movements with blood sugar levels and blood lipids in chronic schizophrenics treated with antipsychotics. METHODS: Thirty-eight male schizophrenic inpatients who were stable in clinical state with medications, were included. The patients who had been already diagnosed as diabetes mellitus(DM), organic brain disorder, substance-related disorder, physical illness were excluded and also we excluded female patients to remove the hormonal effect on TD. Eleven patients who ranked higher(above five) in the Abnormal Involuntary Movement Scale(AIMS) were assigned into 2 groups, a dibenese group and a placebo group. Diabinese or placebos were administrated for 3 weeks with antipsychotics and AIMS was rechecked. RESULTS: There were no correlations between the total AIMS scores and blood sugar and lipids levels in all subjects. The means of total and subscale scores(objective, face, and extremity) of AIMS did not reveal statistical significances between diabinese and placebo groups. However(total, jaw, face, upper arm, and objective feeling), were statistically higher in the diabinese group than those in the placebo group. And correlations of total cholesterol(TC) with fast blood sugar(FBS), weight with body mass index(BMI) and waist, total glycerol (TG) with BMI were statistically significant. CONCLUSION: In this study, there were statistical significances in the changes in ratings of AIMS scores between the diabinese group and the placebo group. Application of oral hypoglycemic agent might be a way of improving abnormal involuntary movements in schizophrenics with abnormal involuntary movements or TD. Althogugh it was not certain that there were correlations of abnormal involuntary movement with blood sugar and lipids, correlations of TC/TG with AIMS, of FBS with AIMS cautiously suggest that the regular check of HbA1C, waist, and weight are recommended for schizophrenics.
Antipsychotic Agents ; Arm ; Blood Glucose* ; Brain Diseases ; Chlorpropamide ; Dyskinesias* ; Female ; Glycerol ; Humans ; Hyperglycemia ; Hyperlipidemias ; Incidence ; Inpatients ; Jaw ; Male ; Movement Disorders ; Placebos ; Schizophrenia