The enantiomers of chlopheniramine were determined separately in plasma by using a coupled achiral-chiral chromatographic system. The two enantiomers of the studied compound and the internal standard were separated from the biological matrix on a cyanopropyl column and reinjected into a chiral amylose AD column where the two enantiomers were separated and quantified by UV detection. The method was validated for chlorpheniramine within the range 0-20ng/ml.
Chlorpheniramine ; Plasma

The elimination of chlorpheniramine (CPAM) racemic isomers from human urine in experiment. The pharmacokinetic elimination of chlorpheniramine in the product contac including racemic chlorphenyramine and phenylpropano …was assessed in 9 health men and 9 women administrating 8mg racemic chlorphenyramine in Contac after an overnight fast. Urine samples were collected up to 144 hours and individual enatiomers of chlorpheniramine was defermined by HPLC method. There was no difference in the elimination of unchanged CPAM in urine from male and female subjects
Chlorpheniramine ; Urine ; Methods

The bioequivalence of two formulations (reference and Vietnamese tested formulation) of racemic chlorpheniramine combined with phenylpropanolamine was assessed in an open-labeled, randomized, crossover two-period study in 12 healthy Vietnamese males aged between 22 and 43 years old, weight between 48kg and 72kg. All 12 subjects received both formulations after an overnight fast and a 7 day wash-out period. Plasma samples were collected up to 168 hours. Plasma concentrations of total chlorpheniramine and individual enantiomers were determined with a validated chiral HPLC method and pharmacokinetic parameters were estimated using a model independent analysis. Bioequivalence was assessed by several different published statistical methods (ANOVA, Confidence Interval, Westlake, and Schuirmann). Results showed that bioequivalence may depend on the statistical and analytical methods used
Chlorpheniramine ; Therapeutic Equivalency

A titration in nonaqueous medium was proposed to determine simultaneously the mixtures of Chlorpheniramine maleat and the other halogen salts (Dextromethorphan HBr and phenylpropanilamin HCl). The first one was assayed for having the equivalent point EP1. For the second halogen salts we added (CH3COO)2 for liberating halogen radicaux and trans forming to base form. This form was recorded the equivalent point EP2.
Chlorpheniramine ; Drug Compounding

Isomeric selectivity of chlorpheniramine in period of binding to protein was demonstrated on serum, plasma used anticoagulant agent citrate- phosphate- dextrose (CPD) anticoagulant agent, albumin solution and refined α- glycoprotein acid solution. The binding rate to protein of optical isomer S(+)-chlorpheniramine is always higher than R(-)-chlorpheniramine with total serum protein (38% vs. 23%), total plasma protein (26% vs. 23%), albumin (20% vs. 15%) and α- glycoprotein acid (23% vs. 5%)
Chlorpheniramine ; Blood Proteins

Chlorpheniramine meleate (CM) is a antihistaminic agent. Assay for chlorpheniramine meleate in the multi-component drugs by colorimetry method. A technique was proposed to increase the accuracy of the assay for chlorpheniramine meleate. The assay of the method is about 2%
Chlorpheniramine ; Pharmaceutical Preparations ; Colorimetry

The concurrent quantification of this 4 factors mixed tablet using HPLC resulted in the establish of a quantifying procedure with high precision (0,87- 1,91%) good accuracy (get backing to 98,8%- 99,5%). Lineal degree was investigated in a large range of concentration and could be applied on diverse mixed tablet samples containing 2-4 active substances of various formulations. The technique gave sombrous advantages, simple, quick, saving the solvant
Dextromethorphan ; Chlorpheniramine ; Phenylpropanolamine

Compounding pellet chlorpheniramin TDKT and builing its formulary from pellet were studied. The result: the optimal formule of memberance prolonging release of chlorpheniramin from pellet was selected. This memberance could quicktly release a part of primary subtance in order to immediately solve alergic symptoms. The rest release constantly prolong in 8 hours
Chlorpheniramine ; Pharmaceutical Preparations ; Membranes

We report. herein a case of pruritic urticatial papules and plaques of pregnancy in a Z8-year-old primigravida. She had the urticarial papules and plaques on the abdomen and thighs, which developed at 30th week of pregnancy. She was treated with topical fluorinated steroid and chlorpheniramine, 6mg/ day. The itching sensation was relieved within 24 hours after the therapy and the skin lesions resolved after delivery.
Abdomen ; Chlorpheniramine ; Pregnancy* ; Pruritus ; Sensation ; Skin ; Thigh

Chlorpheniramine (CPAM) is a chiral antihistaminic drug commercialized as a racemic mixture. The intestinal investigated in rat using in vitro experiment. Experiments showed that the absorption is not stereoselective. Moreover, the in vitro metabolism of CPAM are not modified by modulator of P-glycoprotein and cytochromes P450
Chlorpheniramine ; Glycoproteins ; Metabolism ; Mice ; Animal Experimentation