Evaluation of several antihypertensive regimens involving reserpine, hydrochlorothiazide (Esidrex(R)) and clonidine (Catapres(R)) was conducted on 230 subjects with mild to severe hypertension. Chlordiaxepoxide (Librium(R)) which is a sedative was also administered to observe the effect in patients with mild labile hypertension. The results obtained were as follows; 1. All five regimens of chlordiazepoxide, reserpine, hydrochlorothiazide, hydrochlorothiazide plus reserpine and hydrochlorothiazide plus clonidine produced a significant decrease in average mean arterial pressure (systolic+diastolicc pressure/2) compared to control values (p<0.01). 2. Hydrochlorothiazide plus clonidine was the most effective pressure lowering regimen, resulting in an average fall of 39.3 mmHg in average mean arterial pressure and obtaining excellent result in 28.6% of the cases. 3. The order in the pressure lowering effect was hydrochlorothiazide plus clonidine, hydrochlorothiazide plus reserpine, hydrochlorothiazide, reserpine, and chlordiazide 4. There was no significant difference between hydrochlorothiazide plus clonidine and hydrochlorothiazide plus reserpine (p>0.1). 5. More reduction in diastolic pressure than systolic was observed with hydrochlorothiazide plus clonidine. 6. The results of hydrochlorothiazide alone, hydrochlorothiazide-reserpine and hydrochlorothaizide-clonidine were better than those of chlordiazepoxide and reserpine alone in patients with fundoscopic findings of Keith-Wagener Grade II. 7. There was difference in pressure lowering effect with hydrochlorothiazide plus clonidine between the group with and without albuminuria. 8. Hydrochlorothiazide plus clonidine were extremely effective in patients with severe hypertension, hydrochlorothiazide plus reserpine in patients with moderately severe hypertension, and reserpine and hydrochlorothiazide alone in patients with mild hypertension.
Albuminuria ; Antihypertensive Agents* ; Arterial Pressure ; Blood Pressure ; Chlordiazepoxide ; Clonidine ; Humans ; Hydrochlorothiazide ; Hypertension ; Reserpine

Central serous retinopathies were arbitrarily divided into two groups; one mainly with edema of the macula and the other with discoloration opacity and a number of tiny yellow spots in and around the macula. Eight cases of central serous retinopathy with macular edema were selected to have oral administration of chlordiazepoxide, 20mg to 60mg a day. Of eight cases of the variety, six cases showed a marked improvement of visual acuity and a complete subsidence of macular edema within ten days after the administration of the drug. Two other cases were also benefitted by the regime. The drug was found to be equally effective even in the patients who had been on the other treatments for varying lengths of time without success. The mode of action of the drug is not yet fully understood. It is, however, assumed that the effectiveness of the drug on the disease might be due to relief of the stress which, in turn, leads to the relaxation of spasm of the retinal and or choroidal arterioles in the vicinity of the macula.
Administration, Oral ; Arterioles ; Central Serous Chorioretinopathy* ; Chlordiazepoxide* ; Choroid ; Edema ; Humans ; Macular Edema ; Relaxation ; Retinaldehyde ; Spasm ; Visual Acuity

Female urethral syndrome is a common disorder in women consisted of urinary frequency, urgency, dysuria and suprapubic discomfort without any specific organic changes on corroborative physical and laboratory findings. Allergy, psychic factors, senile atrophy, obstruction and chronic infection of periurethral gland have been implicated at etiologic factors. From Jan. 1982 to Jan. 1983, 22 patients of the female urethral syndrome underwent laboratory examinations and cystourethroscopic examinations. In addition, both 22 cases of the patient group who showed female urethral syndrome with polypoid at the bladder neck and the same numbers of 22 as the control group who had been treated at this hospital with other medical diseases were tested the Minnesota Multiphasic Personality Inventory. Concomitantly, no specific abnormalities were found in both urine findings and cystourethroscopic findings except polypoids at the bladder neck in 22 cases. Female urethral syndrome patients in this study scored up significantly higher on the hypochondriasis, hysteria and depression scales than did the control group, and the results revealed evidence of conversion and psychosomatic etiology. All 22 cases were treated with transurethral fulguration, urethral dilatation and antibiotics. Chlordiazepoxide was added to above mentioned treatment in 15 cases which scored up significantly higher on hypochondriasis, hysteria, and depression scales among 22 cases Excellent result were obtained in 12 out of 15 cases while only 3 out of 7 cases which didn`t add chlordiazepoxide in their treatment had good result.
Anti-Bacterial Agents ; Atrophy ; Chlordiazepoxide ; Depression ; Dilatation ; Dysuria ; Female* ; Humans ; Hypersensitivity ; Hypochondriasis ; Hysteria ; Minnesota* ; MMPI* ; Neck ; Urinary Bladder ; Weights and Measures

AIMTo establish a method for the determination of the five components (reserpine, chlordiazepoxide, hydrochlorothiazide, dihydralazine sulfate, triamterene) in compound hypotensive tablet.

METHODSThe chromatography was performed using a CN column with acetontrile-0.1 mol L(-1) sodium heptasulfonate solution (7:3) and (5:5) as the mobile phases. The detection wavelength was 267 nm for reserpine, chlordiazepoxide and hydrochlorothiazide, 310 nm for dihydralazine sulfate, 360 nm for triamterene.

RESULTSThe linear range of each component was tested, and the recovery and stability of each component was satisfactory, three lots of samples were determined using the method.

CONCLUSIONThis is an accurate and credible quality control method for compound hypotensive tablet.

Antihypertensive Agents ; administration & dosage ; chemistry ; Chlordiazepoxide ; analysis ; Chromatography, High Pressure Liquid ; methods ; Dihydralazine ; analysis ; Drug Combinations ; Hydrochlorothiazide ; analysis ; Quality Control ; Reserpine ; analysis ; Tablets ; Triamterene ; analysis

A 21 year-old female underwent resection of a pheochrocytoma under general anesthesia. The patient was treated with phenoxybenzamine for 5 days preoperatively and premedicated with triflupromazien, Librium, Seconal, pethidine, hydroxyzine and atropine in combination. Following indution of anesthesia with intravenous morphine and thiopental sodium, succinylchoine was administered intravenously and endotracheal intubation was performed. Anesthesia was maintained with nitrous oxide, oxygen and methoxyflurane, using a semiclosed carbon dioxide absorption circle system, and alcuronium was injection intermittently. Blood pressure during manipulation of tumor was increased up to 190/130 torr without arrhythmia and transiently dropped to 70/50 torr immediately after removal. Blood pressure was controlled by i.v. Hartmann's solution and whole blood with Solucortef and Effortil but not norepinephrine was needed. There was no marked tachycardis or arrhythmia during anesthesia, so a beta-adrenergic blocker(Inderal) was not used. The importance of preoperative preparation, premedication and selction of anesthetics is discussed.
Absorption ; Alcuronium* ; Anesthesia* ; Anesthesia, General ; Anesthetics ; Arrhythmias, Cardiac ; Atropine ; Blood Pressure ; Carbon Dioxide ; Chlordiazepoxide ; Etilefrine ; Female ; Humans ; Hydroxyzine ; Intubation, Intratracheal ; Meperidine ; Methoxyflurane* ; Morphine ; Nitrous Oxide ; Norepinephrine ; Oxygen ; Phenoxybenzamine ; Pheochromocytoma* ; Premedication ; Secobarbital ; Thiopental ; Triflupromazine*