Objective To study the clinical applicated value of thrombin injection in the treatment of 30 pa-tients with femoral artery pseudo-aneurysm guided by color Doppler ultrasound .Methods 60 patients with femoral artery pseudoaneurysm were selected as the observation group ,according to a random number table ,they were divided into A group and B group ,A group was treated with ultrasound guided compression therapy ,B group was treated with ultrasound guided thrombin injection;also early femoral artery pseudoaneurysm OK conventional surgical methods for the treatment of 30 patients in the control group .The statistical method of ultrasound-guided two treatment success rate,thrombus formation time and observation group and control group success rate and complication rate .Results Ultrasound-guided compression therapy for 30 cases,14 cases of successful initial oppression ,oppression success rate of 46.6%for the first time,repeat oppression the success rate of 87.5%.Two cases were cured after thrombin injec-tion therapy .B group was treated with thrombin injection of endovascular ,24 cases in 30 cases were cured after first injection,the first injection success rate of 80.0%;all cases were cured after two injections .Thrombus formation time was(0.30 ±0.05)min.treatment success rates for the first time and thrombus formation time were significantly differ-ent(all P<0.01).30 cases were cured by surgical treatment .Postoperative complication rate was 6.7%.The first treatment success rates and complication rates of the two groups were significantly different (P<0.05).The total suc-cess rates of the observation group and the control group were 100%respectively .The difference was not statistically significant(P>0.05).Compared with the observation group ,the incidence rate of postoperative complications of con-trol group was 6.7%(P>0.05).Conclusion In the femoral artery pseudoaneurysm positioning and puncture thera-py,Color Doppler ultrasound-guided thrombin may provide a reliable basis , thrombosis treatment success rate and thrombus formation time were significantly better than that of ultrasound-guided compression therapy ,which has broad application prospects .