1.Spectrum of Neurological Complications Following COVID-19 Vaccination in India
Rashmi DEVARAJ ; Peerzada SHAFI ; Chinmay NAGESH ; Amar NAIDU ; Parthasarathy SATISHCHANDRA
Journal of Clinical Neurology 2022;18(6):681-691
Background:
and Purpose According to WHO statistics, approximately 6.9 billion people worldwide had been vaccinated against SARS-CoV-2 as at October 27, 2021, including around 1.0 billion people in India. Most Indian recipients received the Covishield (ChAdOx1-S/ nCoV-19) vaccine, followed by the Covaxin (an inactivated SARS-CoV-2 antigen) vaccine.This study was conducted to characterize the neurological phenotypic spectrum of patients with adverse events following immunization with any of the available COVID-19 vaccines in India (Covishield or Covaxin) during the study period and their temporal relationship with vaccination.
Methods:
This ambispective multicenter hospital-based cohort study covered the period from March to October 2021. The study included all cases suspected of having neurological complications following COVID-19 vaccination.
Results:
We report a spectrum of serious postvaccination neurological complications comprising primary central nervous system demyelination (4 cases), cerebral venous thrombosis (3 cases), Guillain-Barre syndrome (2 cases), vaccine-induced prothrombotic immune thrombocytopenia syndrome (2 cases), cranial nerve palsies (2 cases), primary cerebral hemorrhage (1 case), vestibular neuronitis (1 case), chronic inflammatory demyelinating polyneuropathy (1 case), generalized myasthenia (1 case), and seizures (1 case).
Conclusions
Although the benefits of vaccination far outweigh its risks, clinicians must be aware of possible serious adverse events associated with COVID-19 vaccinations.
2.Dementia and Parkinsonism-a Rare Presentation of Intracranial Dural Arteriovenous Fistulae.
Manoj GOPINATH ; Chinmay NAGESH ; K SANTHOSH ; ER JAYADEVAN
Neurointervention 2017;12(2):125-129
Intracranial dural arteriovenous fistulae (DAVF) are acquired fistulous communications between dural arterial branches and dural venous sinuses or cortical veins with the nidus located within the leaflets of the duramater. Dementia and Parkinsonism are amongst the rarest of clinical presentations in DAVFs and are important to diagnose early, being treatable with timely intervention. We present an interesting case of a patient who presented with rapidly progressive dementia and features of parkinsonism who was diagnosed to have extensive DAVF and made remarkable recovery after embolization of the fistulae.
Central Nervous System Vascular Malformations*
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Dementia*
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Fistula
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Humans
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Parkinsonian Disorders
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Veins
3.Secondary Movement Disorder in a Case of Diphtheric Encephalitis: Clinical and Neuroimaging Features of a Rare Association
Chinmay P NAGESH ; Sanjiv C CHAMRAJ ; Vijaya Bhaskar SM ; Srikanta JT
Journal of Clinical Neurology 2019;15(3):424-426
No abstract available.
Encephalitis
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Movement Disorders
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Neuroimaging
4.The Imaging of Localization Related Symptomatic Epilepsies: The Value of Arterial Spin Labelling Based Magnetic Resonance Perfusion.
Chinmay NAGESH ; Savith KUMAR ; Ramshekhar MENON ; Bejoy THOMAS ; Ashalatha RADHAKRISHNAN ; Chandrasekharan KESAVADAS
Korean Journal of Radiology 2018;19(5):965-977
Accurate identification of the epileptogenic zone is an important prerequisite in presurgical evaluation of refractory epilepsy since it affects seizure-free outcomes. Apart from structural magnetic resonance imaging (sMRI), delineation has been traditionally done with electroencephalography and nuclear imaging modalities. Arterial spin labelling (ASL) sequence is a non-contrast magnetic resonance perfusion technique capable of providing similar information. Similar to single-photon emission computed tomography, its utility in epilepsy is based on alterations in perfusion linked to seizure activity by neurovascular coupling. In this article, we discuss complementary value that ASL can provide in the evaluation and characterization of some basic substrates underlying epilepsy. We also discuss the role that ASL may play in sMRI negative epilepsy and acute scenarios such as status epilepticus.
Electroencephalography
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Epilepsy*
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Magnetic Resonance Imaging
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Neuroimaging
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Neurovascular Coupling
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Perfusion*
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Seizures
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Status Epilepticus
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Tomography, Emission-Computed