1.Acute necrotising encephalopathy of childhood: A review of two cases
Sidney, Ching Liang Ong ; Nur Azidawati Abdul Halim ; Yuan Hwen, Liew ; Anita Sahal
The Medical Journal of Malaysia 2017;72(5):311-313
Acute necrotising encephalopathy of childhood (ANEC) is
an uncommon disease with characteristic clinical and
imaging findings. We present two cases of ANEC secondary
to Respiratory Syncytial Virus (RSV) and mycoplasma
infections. An eight-month-old boy presented with features
of gastroenteritis but soon developed multiple episodes of
seizures. Blood and CSF cultures were negative but
nasopharyngeal aspirate immunofluorescence was positive
for RSV. A nine-year-old girl presented with abnormal
behaviour following two days of prodromal symptoms. Her
serological markers implicated mycoplasma (IgM titre 1:
640). CT brain of both patients showed bilateral symmetrical
thalamic hypodensities, while MRI revealed more extensive
white matter involvements.
Brain Diseases
;
Mycoplasma Infections
2.Discovery of coarctation of the aorta following renal doppler sonography
The Medical Journal of Malaysia 2018;73(5):330-331
Coarctation of the aorta (CoA) is present in 0.4% of live
births and in 7% of patients with congenital heart disease.
While there may be florid presentations of congestive heart
failure in the neonatal period, the diagnosis during
adulthood is often delayed. We encountered a 20-year-old
woman who was discovered to be hypertensive on routine
check-up. Following bilateral abnormal renal doppler
sonography, MR angiogram revealed a short-segment
stenosis of the descending thoracic aorta. Review of her
chest radiograph showed a small aortic knuckle. This case
highlights an unconventional algorithm in diagnosing aortic
coarctation in adulthood.
5.An Unexpected Cause of Trauma-related Myocardial Infarction: Multimodality Assessment of Right Coronary Artery Dissection.
Pei Ing NGAM ; Ching Ching ONG ; Christopher Cy KOO ; Poay Huan LOH ; Lynette Ma LOO ; Lynette Ls TEO
Annals of the Academy of Medicine, Singapore 2018;47(7):269-271
Adult
;
Aneurysm, Dissecting
;
diagnosis
;
etiology
;
Computed Tomography Angiography
;
methods
;
Conservative Treatment
;
methods
;
Coronary Angiography
;
methods
;
Coronary Vessels
;
diagnostic imaging
;
pathology
;
Electrocardiography
;
methods
;
Heart Injuries
;
complications
;
Humans
;
Magnetic Resonance Imaging, Cine
;
methods
;
Male
;
Multimodal Imaging
;
methods
;
Myocardial Infarction
;
diagnosis
;
etiology
;
therapy
;
Treatment Outcome
;
Wounds, Nonpenetrating
;
complications
6.Clinics in diagnostic imaging (155). Incidental PDA with secondary pulmonary arterial hypertension.
May San MAK ; Ching Ching ONG ; Edgar Lik Wui TAY ; Lynette Li San TEO
Singapore medical journal 2014;55(9):462-quiz 467
We report the case of a 70-year-old man with an asymptomatic large patent ductus arteriosus (PDA) incidentally detected on triple-rule-out computed tomography (CT). CT clearly demonstrated a vascular structure connecting the descending thoracic aorta to the roof of the proximal left pulmonary artery, consistent with a PDA. Secondary pulmonary arterial hypertension was also evident on CT. The patient was eventually diagnosed with acute coronary syndrome and was successfully treated with coronary artery bypass graft surgery and concomitant patch closure of the PDA. This article aims to outline the imaging features of PDA and highlight the information provided by CT, which is crucial to treatment planning. The pathophysiology, clinical manifestations and closure options of PDA are also briefly discussed.
Aged
;
Aorta, Thoracic
;
diagnostic imaging
;
Ductus Arteriosus, Patent
;
complications
;
diagnostic imaging
;
Echocardiography
;
Heart Diseases
;
congenital
;
diagnostic imaging
;
Humans
;
Hypertension, Pulmonary
;
complications
;
diagnostic imaging
;
Infant
;
Male
;
Obesity
;
complications
;
Pulmonary Artery
;
pathology
;
Radiography, Thoracic
;
Tomography, X-Ray Computed
;
Treatment Outcome
;
Young Adult
7.Trends of platelet inhibition in different clopidogrel pretreatment patterns in malaysian patients undergoing elective percutaneous coronary intervention.
Tiong, Wen Ni ; Mejin, Melissa ; Fong, Alan Yean Yip ; Wee, Ching Ching ; Lai, Lana Yin Hui ; Hwang, Siaw San ; Bujang, Mohamad Adam Bin ; Tiong, Lee Len ; Ong, Tiong Kiam
The Medical Journal of Malaysia 2013;68(4):326-31
9.Pediatric multiple sclerosis is similar to adult-onset form in Asia.
Heng Thay Chong ; Patrick C.K. Li * ; Benjamin Ong ** ; Kwang Ho Lee *** ; Ching Piao Tsai **** ; Bhim S. Singhal ***** ; Naraporn Prayoonwiwat ****** ; Chong Tin Tan
Neurology Asia 2007;12(1):37-40
Pediatric-onset multiple sclerosis is underreported because of difficulty in diagnosis and assessment. In Western series, pediatric-onset disease showed significant differences from adult-onset disease with higher female preponderance, polysymptomatic in onset, frequent systemic manifestation in relapses, higher relapse rate, but less disability, and fewer lesions in brain magnetic resonance imaging. Multiple sclerosis manifests differently in Asians, yet there was no large series of pediatric-onset multiple sclerosis reported. We found that pediatric-onset disease in Asians showed greater similarity with adult-onset disease without the reported differences in female preponderance, relapse rate, and magnetic resonance imaging findings. There were also similar proportion and clinical features in optico-spinal form, and long spinal cord lesions were common in both groups. The significant difference was less disability among the pediatric-onset group. Thus, although multiple sclerosis in Asia is different from Western countries, there is greater similarity between the pediatric-onset and adult-onset group in Asia.
Multiple Sclerosis
;
Adult
;
Asia
;
Pediatric
;
Cancer Relapse
10.Exercise induced cramps and myoglobinuria in dystrophinopathy – a report of three Malaysian patients
Azlina Ahmad Annuar ; Kum Thong Wong ; Ai Sze Ching ; Meow Keong Thong ; Sau Wei Wong ; Feizel Alsiddiq ; Lai Choo Ong ; Khean Jin Goh
Neurology Asia 2010;15(2):125-131
Dystrophinopathies commonly present as Duchenne or Becker muscular dystrophy but rare, unusual
phenotypes have also been described. We have identifi ed three Malaysian boys with an unusual form
of dystrophinopathy, presenting with exercise-induced cramps and myoglobinuria, but with no apparent
muscle weakness. Immunohistochemistry for dystrophin and genetic analysis confi rmed the diagnosis.
The frequency of this phenotype is unknown but there have been several case reports. Consistent with
these reports, we also found that two of our patients had deletions in the rod domain of dystrophin,
which has been suggested to be associated with this unusual manifestation