Objective: To investigate the efficacy and safety of sertraline combining with quetiapine in the treatment of obsessive-compulsive disorder (OCD) .Methods: A total of 86 patients who met the criteria for OCD in International Classification of Diseases (ICD-10) were randomly assigned to two groups. One group was treated with sertraline combining with quetiapine and die other with sertraline only for 8 weeks. The efficacy was measured wim the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the Hamilton Depression Scale (HAMD) . The side effects were assessed with the Treatment Emergent Symptoms Scale (TESS) . Results: One patient in sertraline group fell off and was out of statistical analysis. At endpoint the significant improvement rate in the combining group was higher than that in the sertraline group (72.1% vs. 47.6% , P = 0.021) . In combining group, the YBOCS score [(25.00 ± 5.19) vs. (11.74 ± 4.50), P < 0.01] and HAMD score [(14.47 ± 4.05) vs. (6. 86 ±2.61), P < 0.001] were decreased after treatment In sertraline group, the YBOCS score [(24.55 ± 3.60) vs. (14.38±4.18), P<0.001] and HAMA score [(14.79 ± 3.77) vs. (8.29 ±3.04), P <0.001] were also decreased after treatment There were significant differences between the two groups (Ps < 0.05) . There were no significant differences between the two groups in the TESS score at the end of 2, 4, 6 and 8 weeks (Ps > 0.05) . The incidence of drowsiness and tachy-heart rate in the combining group was high than that in the control group (37.2% vs. 4.8% , P <0.001; 27.9% vs. 4. 8% , P=0.004) . But most patients with these two kinds of side effects were disappeared in 2 weeks. There were no significant differences between the two groups in other side effects such as nausea, anxiety, headache, and constipation (Ps > 0.05) .Conclusion: The addition of quetiap-ine to sertraline therapy has been found to be effective and well-tolerated approach in patients with OCD.

Objective: To examine the characteristics of childhood traumatic experiences in borderline personality disorder (BPD) in college students. Methods: The Personality Diagnosis Questionnaire-~(4+) (PDQ-~(4+)), Personality Disorder Interview- Ⅳ (PDI - Ⅳ) and Childhood Trauma Questionnaire -28 Short Form (CTQ-SF) were administered to 3227 college students of sophomore and junior. Results: (1) In the investigation of PDQ-~(4+), 31 subjects with childhood traumatic experiences (0.96%) were diagnosed as BPD, and the total score of BDL sub-scale was (2. 62 ± 1.70), including 18 females and 13 males. In CTQ test, the scores of bad environment in females were significantly higher than that in males [(13.63±4.54) vs. (9.83±1.95), P<0.01] . (2) Subjects with BPD got higher scores than normal controls in CTQ-SF, such as the emotional abuse [(2.11 ±0.77) vs. (1.66±0.49), P<0.01] .Conclusion: college students with borderline personality disorder mostly have d different childhood traumatic experiences, and there exists a sex difference.

Objective: To explore the effects of sensory integration training on the behaviors and cognition in children with attention deficit hyperactivity sorder (ADHD) . Methods: Fifty-two children with ADHD (experimental group) were undergone sensory integration training for 60 times and their behaviors were evaluated with the Corners Parents Symptom Questionnaire (PSQ), and the cognition function was determined with the Combined Raven's Test (CRT) and Wisconsin Card Sorting Test (WCST) before and after the training. Another 52 healthy volunteers were recruited as controls and given the corresponding tests described above for comparison of the results. Results: The scores of conduct disorder, compulsion, hyperactivity and hyperactivity index in children with ADHD were decreased significantly than those of controls after training [(0.60 ± 0. 34) vs. (0.68 ± 0.35), (0.92±0.57) vs. (1.25±0.70), (0.82±0.29) vs. (1.08±0.44); P<0.05] .Inaddition, the improvement was found in IQ, categories control, and conceptive level as compared with that before the training [such as IQ, (105. 37 ±22.76) vs. (97. 37 ±24.15); P<0.001], whereas the scores of response error, response error percentage, first category and persistent errors were decreased after the training [such as response error, (39.40 ± 22.22) vs. (46.60 ±23.44), P<0.001] . For the experimental subjects, the scores in the first response number and the persistent errors percentage right after the training were higher compared with the controls [(12.03 ±5.08) vs. (10.65±0.84), (50.75 ±18.35) vs. (39.95 ± 15. 34); Ps<0.05] .Conclusion: The sensory integration training can improve the behaviors and cognition in children with ADHD, but it produces fewer effects on some of the executive functions despite clinical symptom relief to a certain extent.

Objective:To investigate the early behavioral characteristics of children with autism within the age of 1.5 to 3 years in order to provide basis for early diagnosis and intervention. Methods: Using mass random sampling, 8006 children aged 1.5 to 3 years in nine districts in Tianjin were screened with a self-made questionnaire. Totally 432 children with suspected autism were diagnosed and rated according to the diagnosing criteria of DSM-Ⅳ and assessed with the Childhood Autism Rating Scale (CARS). Their behavioral characteristics were assessed with the Autism Behavior Checklist (ABC) and the early behaviors were compared between the children with autism and the normal children. Results: Children with autism in infants and suspicious positive group were different from normal children in 9 items such as" Abnormal language skills", "No index points the light", "No acts of posing as the game", "Could not normally play with toys, "and others(P <0.05). Children with autism in infants were different from suspicious positive group in 5 items such as"Children have no eye contact with others". The items with positive rate higher than 95% were interpersonal communicate barriers, mimic the functional deficiencies, language communicate barriers, non-verbal communication barriers and mental deficiency in CARS. The results of ABC showed that severe autism had much higher scores than mild to moderate autism both in the sense (S) and body function(B) areas [(8.00 ±3.30) vs. (5.15 ±2.58), (12.00 ±6.12) vs. (6.15 ±3.26); Ps <0.05]. Conclusion: The develop mental and behavioral symptoms can exist in early period of life of children with alltism, to which highly attention should be paid.

Objective: To explore the prevalence and co-morbidity in depression disorder among children and adolescents in Chengdu City. Methods: Using a one-phase design, 4S8S children and adolescents in grades 1～10 were assessed with the Strength and Difficulty questionnaire (SDQ) and Development and Well-Being Assessment (DAWBA) . A structured interview with verbatim reports was reviewed by clinicians so that information from parents, teachers, and children were combined in a manner that emulated the clinical process. Results: (1) The rate of depressive disorder was 1.2% , and that in girls was much higher than that in boys after 12 years old (2.56% vs. 1.42%) . (2) The rate of depressive disorder increased with age from 0.10% (6～8 years) to 2.59% (≥ 15 years) . (3) The co-morbidity was 40% . The most common comorbidity diagnosis was anxiety disorders (29.1%) and behavior disorders (25.5%) . Conclusion: The prevalence of depressive disorder among children and adolescents in Chengdu is 1.2%. Gender and age may be the related factors. The co-morbidity is common in children and adolescents with depression disorder.

Objective: To develop the Risk Assessment Scale of Severe Psychiatric Patients in Community and test its reliability and validity. Methods: A random sample of 860 severe psychiatric patients, which was selected from 8 communities in Chaoyang District of Beijing, completed the Risk Assessment Scale of Severe Psychiatric Patients in Community. The internal consistency reliability, the observer reliability, and the correlative coefficients between the total and items of the scale were analyzed, and the exploratory factor analysis was conducted. Results: (1) The Cronbach's coefficient of the scale was 0. 86, and the observer coefficient was 0.92. (2) The Spearman correlative coefficients between the total and items ranged from 0.40 ～ 0.56. (3) Exploratory factor analysis showed that the scale had 4 main factors, all of which could account for 68.14 percent of the whole variance, and the ten item loadings ranged from 0. 60 ～0.91. (4) The patient who scored higher than 35 was called high risk patient Causing trouble behavior of high risk patient was obviously higher than others. Conclusion: The results indicate that the Risk Assessment Scale of Severe Psychiatric Patients in Community has good reliability and validity. It can be used to assess the risk of severe psychiatric patients in community.

Objective: To build the relationship model of job burnout, insecurity psychology, and insecurity behavior for miners. Methods: The valid random samples included 1229 miners from national and private coal mines, who were investigated with the revised Job-Burnout Inventory for Miners, Insecurity Psychology Inventory, and Insecurity Behavior Inventory. The data was analyzed through SPSS15.0 and AMOS7.0. Results: The three dimensions of job burnout had significant direct effect on insecurity behavior [β =0.008, 0.047, 0.019) .The three dimensions of job burnout had significant direct effect on psychological paralysis (β =0.031, 0.203, 0.374) and helplessness on security (β =0.206, 0.374, 0.472) . Emotional exhaustion and disengagement from work had significant effect on temporary psychology (β =0. 192, 0.411) and antagonistic psychology (β =0.079, 0.596) . Four dimensions of insecurity psychology had significant effect on insecurity behavior (β = 0.092, 0.023, 0.093, 0.097) and it was a mediator in the model. Conclusion: Miners'job burnout have significant direct effects on insecurity behavior, but also have indirect effects through the insecurity psychology mediator.

Objective: To examine the prevalence and risk factors of criminal behavior among persons with schizophrenia in a rural area. Methods: A 14-year prospective follow-up study (1994 - 2008) was conducted on criminal behavior, clinical symptoms, social functioning, treatment and caring status among 510 persons with schizophrenia in Xinjin County, Chengdu. The instruments included the Present State Examination (PSE-9), Social Disability Screening Schedule (SDSS), and Positive and Negative Syndrome (PANSS) .Results: Totally 489 patients (95.9%) were followed up. The life-time prevalence of criminal behavior among these patients was 13.5%. Criminal behavior was more likely to happen among the persons who were unmarried (19.1%), younger t (41.2 ± 16.6) years old], and had earlier onset age [(28.4 ± 10.4) years old] .In the follow-up data, the rates of patients'criminal behavior were relatively higher among these patients who had poor family economic status (16.6%), no caregiver (28. 6%), homelessness (25.0%), and higher positive (14.1 ± 7.4), negative (19.3±10.2) and total scores (68.7±28.7) of PANSS (P<0.05) .Conclusion: The criminal behavior in patients with schizophrenia is common in rural areas and may be affected by multi-factors. The risk factors of criminal behavior in persons with schizophrenia, such as their marriage, family intervention and social support services, should be considered for community mental health policy making, community mental health services and family interventions.

Objective:To probe into the influences of psychosocial risk factors and family psyche environment on smoking behavior of adolescents.Methods:Psychosocial risk factors and family psyche environment of 806 adolescents with smoking behavior and that of 3603 controls were investigated with Family Environment Scale, Symptom Checklist 90 and Behavior Questionnaire.Results:Rebelliousness, Risk Taking, Early Maturity, Problem Helplessness of adolescents were related to smoking. The scores of cohesion, expressiveness, achievement orientation and intellectual-culture orientation in Family Environment Scale of the smoking group were lower than those of controls (P

The Japanese orphans who remained in Northeastern District of China atthe end of world War Ⅱ were raised by their Chinese foster parents and grew up in Chinesesociety,but more than forty years later,they displayed even many characteristics closely relat-ed to Japanese culture.The findings of the 54 Japanese orphans investigated indicate signifi-cant relationship between early childhood experience and the development of personality andpattern of behavior in adulthood.