Objective:To investigate effect of curcumin on serum gelatinases level in patients with unstable angina pectoris (UAP). Methods:A total of 80 UAP patients admitted from January 2010 to September 2010 were enrolled and randomly divided into curcumin treatment group (n=40) and routine treatment control group (n=40). Serum levels of gelatinases [contain matrix metalloproteinase (MMP)-2 and -9] of the two groups were measured before and 30d after treatment.Results: Compared with before treatment , after treatment, serum levels of gelatinases significantly decreased [MMP-2:(52.64±6.77)ng/ml vs.(32.65±1.67)ng/ml,MMP-9:(56.75±7.34)ng/ml vs.(35±1.88)ng/ml]in curcumin treatment group (P<0.01), and they were significantly lower than those of routine treatment control group[MMP-2:(32.65±1.67)ng/ml vs.(37.78±2.76)ng/ml,MMP9:(35±1.88)ng/ml vs.(40.23±1.95)ng/ml]],P<0.05. Conclusion:Curcumin could decrease serum levels of gelatinases in patients with unstable angina pectoris, and possesses effect stabilizing coronary artery plaque.

Objective:To explore the clinical application value ofChinese evaluation method of 10-year morbid risk of ischemic cardiovascular diseasesself developed from China.Methods:Chinese evaluation method of 10-year motbid risk ofischemic cardiovascular diseasesdeveloped bv cardiovascular diseaseinstitute of Chinese academy of medical science,was used to evaluate motbid risk of cardiovascular diseases of 2465 community residents in Chaoyang district of Beijing.Relative analysis was done then.Results:(1)Compared with female group,mean values of systolic blood pressure[(122.84±16.42)mmHg vs.(126.83±16.36)mmHg],diastolic blood pressure[(80.67±9.51) mmHg vs.(84.54±9.89)mmHg]and total cholesterol[(4.86±1.06)mmol/L vs.(5.01±0.97)mmol/L]significantly increased in male group,P＜0.001 all;(2)For the ratio of subjects whose 10-year morbid risk of ischemic cardiovascular diseases≥10%(high risk subjects),was of 3.28% in men and significantly more than that of women(1.59%)P ＜0.05.It was consistent withthe data of absolute risk ofischemic cardiovascular diseasesfrom Chinese 9903 cases survey and follow up 15.1 years by the collaborative research group of the Chinese national 10th five years plan project.Conclusion:Chinese evaluation method of 10-year morbid risk of ischemic cardiovascular diseasescan accurately detect distribution condition of morbid risk among population andit makeforto simple screening of high risk population.

Objective:To study the practical methods and the results of the rehabilitation education.Methods: One hundred cardiovascular patients over 65 years old who are receiving the com prehensive rehabilitation treatment are selected for rehabilitation education,an d comparisons were conducted between pre-and post-education.Results: After receiving the rehabilitation education,the cognition on disease (51%→89%)、rehabilitation therapy(47%→93%),confidence of to win a victory on d i sease(53%→90%)、attendance rate(71%→98%) increase obviously,and irrationality living habit decrease obviously(36%→13%). Conclusion: The rehabilitation education plays an important role in the rehabilitation of t he aged cardiovascular patients,and it is very practical and feasible.

Objective:Dynamically observe the serum D-dimer level of patients wit h thrombus, for instructing drug therapy and judging prognosis.Methods: Detect serum D-dimer level by latex agglutination in 113 cases, among these 20 cases were normal(control group), and 93 cases were patients with thrombus(patient g roup).Results:Detecting results of control group were all negative, positive rate of patient group were 67%～100% according type of disease.Conclusion:Level of serum D-dim er is obviously increase in patient with thrombus. It's ideal detecting index of patient with thrombus.

Objective:To investigate the predictive value of QT interval dispersion (QTd),cor rected QT interval dispersion (QTcd) and corrected QT interval(QTc) of car diac events in patients with congestive heart failure (CHF).Methods: QTd、QTcd、QTc and QTcd/QTc of 106 CHF patients were reviewed. Results:QTd、QTcd、QTc and QTcd/QTc of patients with and without cardiac events had significant difference respectively(P<0.05、<0.01、<0.05、<0.001 respectively).Conclusion: QTd、QTcd、QTc and QTcd/QTc are independent factors in predictin g cardiac events of CHF patients. In which,QTcd/QTc is the most accurate factor.

Objective: To study the correation between carotid artery atherosclerosis and coronary heart disease (CHD). Methods: Color Doppler flow imaging was employed to evaluate carotid artery atherosclerosis in 90 patients with CHD, carotid artery ultrasonography and coronary angiography were performed simultaneously in 20 cases. Results: The thickness of internus-middle membrane and the index number of atheroma both increased remarkably in all cases, and the group with MI had obvious abnomal parameter of blood stream in internal carotid artery. The conformed rate of coronary angiography with ultrasonography in carotid is 75 % in 20 cases,and the moreserious the pathological change of coronary is, the higher the happening rate of carotid artery atherosclerosis is. Conclusion: The degrees of carotid artery atherosclerosis can reflect the degree of pathological changes of coronary indirectly.

Objective: The aim of our study was to analyse the death cause and related factors of death in hospital of patients after cardiac valve replacement (CVR). Methods: Regression analysis of 34 patients' data was executed. Results: Death rate was 9.9 %, death cause: (1) L.ow cardiac output syndrome is the first complication and death cause (2.6 % ), which was closely related to cardiac function (grade Ⅳ ) before operation, LVEDD＞8.0 cm, LVEF＜0. 40, GR ＞80%, emergency operation, long time of arterial block, etc; (2) Ventricular tachycardia、 ventricular fibrillation is the second cause of death (2. 1%); (3) Respiratory failure (4) Post-operation hemorrhage inducing pericardial tamponade and shock; (5) Postoperation infection of replaced valve and brain complications. Conclusion: The success rate of operation can be increased by selecting patients strictly, improving operation methods, enhancing periopertive monitor.

Objective: To investigate the alteration of red cell deformability (RCD) and adenosine triphosphatase (ATPase) activity of cell membrane in essential hypertensive (EH) patients and essential hypertension patients complicated with cerebral infarction (HCI). Methods: Twenty healthy individuals, 30 EH patients and 30 HCI patients were selected as subjects. The erythrocyte deformability indexes (DI)、 Na+, K+-ATPase and Ca2+ATPase activities were examined. Results: (1) EH patients had significantly higher DI, lower ATPase activity as compared to healthy individuals. There were significantly negative correlation between DI and ATPase activity, and a significantly positive correalation between DI and diastolic blood pressure in EH patients; (2) There was significantly higher DI, lower ATPase activity in HCI patients than those in EH patients. There was significantly negative correlation between DIand ATPase activity in HCI patients. Conclusion: (1) RCD decreases in EH patients, and RCD is correlated to the decreased ATPase of cell membrane and elevated blood pressure; (2) The decreased RCD level may be related to the occurrence of HCI.

Objective: To explore the significance of examination of spectrum ECG in patients with coronary heart disease (CHD). Methods: Spectrum ECG and ECG、 vectorcardiogram examination were meanwhile executed in 254 patients with coronary heart disease. Results: Diagnose coincidence rate of CHD was 66.9% by spectrum ECG and ECG、 vectorcardiogram examination. Conclusion: Spectrum ECG is a new detect method for electrocardiogram information.

Objective: To observe the effects of type 2 diabetes mellitus patients with hypertension on lipid metabolism and insulin sensitivity. Methods: A case-matched study of fasting plasma glucose (FBG), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HIDL), low density lipoprotein cholesterol (LDL), insulin (FIN), C-peptide (FCP) and insulin sensitivity index (ISI) were detected in type 2 diabetes mellitus patients with and without hypertensiorn. Results: Twenty patients with type 2 diabetes mellitus complicated hypertension had higher TG、 FINS and FCP, lower HDL and ISI levels than 20 patients with type 2 diabetes mellitus without hypertension. Conclusion: Type 2 diabetes mellitus with hypertension had more remarkable lipid metabolic disorder and insulin resistance than type 2 diabetes mellitus without hypertension.