Objective: To investigate the therapeutic effect of creatine phosphate sodium (CP, Neoton) at early stage of myocardium diastolic dysfunction. Methods: A total of 138 cases with myocardium diastolic dysfunction were divided into CP group (n=109) and routine treatment group (n=29). All the patients received routine treatment. The CP group received CP treatment based on routine treatment(CP 2g+5%glucose or 0.9% sodium chloride 100ml, iv. drip, for patients with mild diastolic dysfunction was 1time/d, patients with moderate diastolic dysfunction was 2 times/d), duration was 7~14 days. Color-coded Doppler echocardiography was used to detect transmitral peak early diastolic velocity (E-wave)，transmitral peak late diastolic velocity (A-wave)，peak early diastolic velocity of mitral annulus (Ea), and peak late diastolic velocity of mitral annulus(Aa), and the value of E/A ,Ea/Aa and E/Ea were calculated. Symptoms, signs and items from echocardiography were compared between the two groups before and after treatment. Results: After treatment, all symptoms and signs of patients in two groups significantly improved (P<0.05~0.01), and the marked effective rate in CP group was significantly higher than that of routine treatment group (96.2% vs. 57.1%, P<0.01). In CP group, the marked effective rate of E/A (81.65% vs. 10.34%), Ea/Aa (83.49% vs. 13.79%) and E/Ea (92.86% vs. 12.00%) were significantly higher than those in routine treatment group (P<0.01all). Conclusion: Creatine phosphate possesses marked effect for improve patient’s condition and diastolic dysfunction.

Objective: To determine the national norm of Chinese questionnaire of quality of life in Chinese patients with cardiovascular diseases (CQQC) according patients with hypertension, coronary artery disease（CAD）, and congestive heart failure（CHF）and to analyze the influence factors. Methods: The quality of life was estimated by CQQC to evaluate 7937 persons normal and with cardiovascular diseases（contain with hypertension, CAD, and CHF ） in 28 hospitals of 19 cities across China. The data were compared in gender, age, exercise, psychologic condition, education, number of family member and medical cost. Results: 1、The mean scores（national norms）of normal persons were （95.74±23.21）; 2、The scores of hypertension patients were （73.75±23.62）, the scores of hypertension stage 3 group （69.06±21.78）were least compared with other stages（P<0.01）; 3、The scores of CAD patients were（64.67±20.59）, the scores of unstable angina group（55.37±18.62）were least compared with other types in CAD patients（P<0.01）; 4、The scores of CHF patients were （40.36±17.24）, it was least compared with those of hypertension and CAD patients （P<0.01）; 5、Influence factor: （1）Sex, age: The mean scores were （71.41±27.8）for 7937 persons, the scores of male persons were significantly higher than those of female (P=0.000). In normal persons, along with age increased, the scores decreased （P<0.05） ; except ≥70 ages group, the scores of male persons were higher than those of female（P<0.05） ; （2）Exercise: The scores of patients participating exercise were significantly higher than those of no participating exercise [（72.64±21.87）vs.（66.91±23.13）, P=0.000]; （3）Psychological condition: The scores of patients with healthy psychological condition were significantly higher than those of with psychologic disorder [（70.13±25.66）vs.（68.91±20.44）, P=0.001]; （4）Other: patients with better education, more than 1 family members and medical insurance or public expense had more scores (P<0.05～0.001). Conclusions： The sample size is large and the datum is reliable for Chinese questionnaire of quality of life in Chinese patients with cardiovascular diseases. It can reflect influence of age, sex, exercise, psychologic condition, family, education background, medical condition and disease, its item is brief, clear, and operation is easy, so it may well be spread.

Background and Object: Percutaneous coronary intervention (PCI) on ostial lesions in coronary arteries associated with higher procedural difficulty and complication morbility. It has been technically difficult because it should be done with precise stent placement in ostium and absence of side branch compromise. The Szabo technique consists of side branch wiring through most proximal stent strut as well as main branch wiring through stent lumen. The side branch wire or anchor wire prevents stent advancement beyond ostial segment and makes possible the accurate stent implantation in ostium. The purpose of this study is to evaluate the safety, feasibility and success rate of Szabo technique by analysing technical, angiographic and IVUS (Intravascular Ultrasonography) findings. Methods: The data of 39 PCIs in 39 patients with a significant lesion at a coronary artery ostium which was treated percutaneously using Szabo technique were retrospectively analysed. The technically successful procedure was defined as there was neither stent loss nor second guide wire pull back during stent advancement. A successful procedure from angiographic point of view was defined as a precise stent implantation at ostium without side branch compromise. Successful procedure from IVUS point of view was defined as accurate stent placement in ostium without proximal protrusion and without any stent uncovered area. A total of 39 patients was with 28 males and 11 females. They aged from 43 to 79 years with a mean age of （65±12）years. The 6F and 7F guiding catheter were used in 35 (89.7%) and 4 (10.3%) patients separately. The access was radial in 31 (79.5%) and femoral in 8 (20.5%) patients. The culprit vessel was left anterior descending (LAD) in 26(66.7%), right coronary artery (RCA) 5 (12.8%), circumflex-obtuse marginal (LCX-OM) 3(7.7%), and posterior descending (PDA) 5(12.8%). IVUS was performed through culprit vessel in 30 (76.9%) and was also done in side branch in 9 (23.1%) patients after stent implantation. Results The procedure was technically successful in 36 (92.3%) patients. All technically successful patients had angiographic success (100%). IVUS examination of culprit vessel showed accurate stent placement in ostium 29 (96.7%) and slight stent proximal protrusion in 1(3.3%) patients. No serious complication occured. Conclusions This study shows that Szabo technique is safe and feasible for PCI in ostial coronary artery lesions with a high angiographic success rate，its deserved to spread.

Objective: To explore the clinical application value of “Chinese evaluation method of 10-year morbid risk of ischemic cardiovascular diseases”self developed from China. Methods: “Chinese evaluation method of 10-year morbid risk of ischemic cardiovascular diseases”developed by cardiovascular disease institute of Chinese academy of medical science, was used to evaluate morbid risk of cardiovascular diseases of 2465 community residents in Chaoyang district of Beijing. Relative analysis was done then. Results: (1) Compared with female group, mean values of systolic blood pressure [(122.84±16.42) mmHg vs. (126.83±16.36) mmHg], diastolic blood pressure [(80.67±9.51) mmHg vs. (84.54±9.89) mmHg] and total cholesterol [(4.86±1.06) mmol/L vs. (5.01±0.97) mmol/L] significantly increased in male group, P<0.001 all; (2) For the ratio of subjects whose 10-year morbid risk of ischemic cardiovascular diseases≥10% (high risk subjects), was of 3.28% in men and significantly more than that of women（1.59%） P<0.05. It was consistent with the data of absolute risk of ischemic cardiovascular diseases from Chinese 9903 cases survey and follow up 15.1 years by the collaborative research group of the Chinese national 10th five years plan project. Conclusion: “Chinese evaluation method of 10-year morbid risk of ischemic cardiovascular diseases”can accurately detect distribution condition of morbid risk among population and it make for to simple screening of high risk population.

Objective: To investigate effect of curcumin on serum gelatinases levels in patients with unstable angina pectoris（UAP）. Methods： A total of 80 UAP patients admitted from January 2010 to September 2010 were enrolled and randomly divided into curcumin treatment group (n=40) and routine treatment control group (n=40). Serum levels of gelatinases [contain matrix metalloproteinase（MMP）-2 and -9) of the two groups were measured before and 30d after treatment. Results：Compared with before treatment , after treatment, serum gelatinases levels significantly decreased [MMP-2：（52.64±6.77）ng/ml vs. （32.65±1.67）ng/ml，MMP-9：（56.75±7.34）ng/ml vs.（35±1.88）ng/ml ] (P<0.01) in curcumin treatment group (P<0.01), and they were significantly lower than those of routine treatment control group [MMP-2：（32.65±1.67）ng/ml vs.（37.78±2.76）ng/ml，MMP-9：（35±1.88）ng/ml vs.（40.23±1.95）ng/ml ] , P<0.05 all. Conclusion：Curcumin could decrease serum levels of gelatinases in patients with unstable angina pectoris, and possesses effect of stabilization coronary artery plaque.

Objective: To explore the efficacy of esmolol on cardiac ischemia in patients with serious coronary lesions who are not candidates for coronary revascularizations. Methods: Fifty seven aged patients (34 male) with serious coronary artery disease not candidates for coronary revascularizations were included. All patients had classical angina involved in cardiac ischemia, and definitely ischemic ST-segment depressions in surface electrocardiogram, however which were not relieved by routine treatment including intravenous nitrate or even morphine. All patients received loading dose injection and continuously intravenous infusion of Esmolol, and the baseline characteristics before treatment and the effects at 4 hours after infusion of Esmolol were carefully recorded. Results: After infusion of Esmolol, the ischemia-related symptoms of 41 patients completely relieved, and their ST depressions recovered to the baseline accompanied with significant reduction in blood pressure and heart rate (P＜0.0001 all) within (66±23) min. Moreover, nine patients were observed that their ischemia-related symptoms were relieved and ST alteration recovered partially (P＜0.0001 both) at four h after continuous infusion of esmolol. Conclusion: Esmolol is effective to relieve the serious cardiac ischemia-related symptoms and ST-T alteration of ECG in patients with serious coronary lesions.

Objective:To study the effect of earlier rehabilitation therapy on motor function in pati ents with acute cerebrovascular accident(ACVA).Methods:Thirty ACVA patients were therapy by technology of bobath and brunnstrom,and motor function was evaluated by score chart of fugl-meyer.Results:Motor function obviously ameliorated in rehabilitation group with the 72.33%、20%、6% patients respectively recove ring to mild-moderate、obvious、severely dyskinesia,compared with that of contrast group(20%、6%、20%)(P<0.05). Conclusion:Earlier rehabilitation therapy obviously ameliorates motor function and increase quality of life in ACVA patients.

Objective:To Explore the correlation between silent cerebral infarcti on(SCI) and aged depression.Methods:SCI was analyzed in 90 aged patients w ith or without depression. Results:Incidence rate of SCI was 71.1% in 45 aged p ersons with depression(depression group), but incidence rate of SCI was 13.56% i n 45 aged persons without depression(no depression group). Compared no depressio n group the SCI incidence rate of depression group was obviously increase(P< 0.01).Conclusion: There is significantly correlation between SCI and aged depression

Objective: To explore relation among abnormal pulse pressure (PP) and cardiovascular risk factors, cardiac function in Tibetan adults through survey on distributive characteristics of PP in Tibetan adults from Songpan county, Sichuan province in China. Methods: An cross-section study was carried out in Songpan county, Sichuan province of China. Questionnaire investigation and Physical examination were performed by multi-phase, stratified, unequal proportional and random cluster sampling to investigate 1015 Tibetan adults aged 18~74 years. Results: In Songpan county the average PP is （45.59±14.22）mmHg ; the incidence rate of abnormal PP was 14.09％（143/1015）. Multifactor linear regression and Logistic regression analysis showed that abnormal PP was positively related with age (OR=1.05, P<0.05) and negatively related with level of high density lipoprotein (OR=-2.69, P<0.05). Compare with normal PP group, systemic vascular resistance [SVR, (1112.61±346.74) kPa/L vs. (1308.27±354.87) kPa/L, t=-4.87] significantly increased, levels of cardiac index [CI, (3.55±1.00) L/min•m2 vs. (3.22±0.54) L/min•m2, t=3.08] and stroke index [SI, (45.68±12.76) ml/m2 vs. (39.45±9.52) ml/m2, t=4.37] significantly decreased in abnormal PP group (P<0.05 all). Conclusion: Abnormal PP is common in Chinese Tibetan adults aged 18~74 years, which associated with cardiovascular risk factors and change of cardiac function. Health management for Tibetan adults with abnormal PP is strongly advocated.

Objective: To explore the relationship between lifestyle and ankle-brachial blood pressure. Methods: Ankle-brachial blood pressures of 2121 adults from all over China were measured with self-developed KD-991 portable ankle-brachial blood pressure simultaneous detecting instrument. They were divided into smoking group and no smoking group, heavy drinking group and moderate drinking group, exercise group and lack of exercise group and comparisons of abnormal ankle-brachial index (ABI, ≤0.9 or≥1.3) rate between paired two groups were performed. Results: Rate of abnormal ankle-brachial index (ABI, ≤0.9 or≥1.3) in smoking group (15.3%), heavy drinking group (13.6%) and lack of exercise group (10.5%) were significantly higher than those of no smoking group (7.9%), moderate drinking group (7.5%) and exercise group (7.4%) respectively, P<0.05 all. Conclusion: Unhealthy lifestyle is related to abnormal ankle-brachial blood pressure and it is very good to prevent occurrence of atherosclerosis , early discover and effectively control its development using ABI to guide people to change unhealthy lifestyles.