Cardiorespiratory fitness(CRF)descends after stroke because of hemiplegia and adaption of insulin,musculoskeletal,cardio-vascular and respiratory system.Aerobic exercise training can improve CRF of individuals with stroke, while robotic-assisted exercise is probably safety and effectiveness for patients with severe stroke or patients within one week after stroke.

Objective To explore the effect of transplantation of neural stem cells(NSCs)pretreated with brain-derived neurotrophic fac-tor(BDNF)on acute ischemic stroke in mice.Methods NSCs from a newborn(one day)C57BL/6 mouse were isolated and cultured in vi-tro.A total of 150 healthy C57BL/6 mice,ten-week-old,were randomly divided into five groups,that group A accepted sham operation,and groups B,C,D and E were subjected to focal ischemia by photothrombosis.Group D was transplanted NSCs 24 hours after ischemia,while group E transplanted NSCs pretreated with BDNF and group C accepted same volume of medium.All the groups were tested with rotarod test and grip strength one day before transplantation and three,seven,14,21 and 28 days after transplantation.The differentiation of NSCs in groups D and E were observed immunofluorescence staining of microtubule-associated protein-2(MAP-2)and glial fibrillary acidic pro-tein(GFAP).Results The time on rotarod arranged from more to less was groups E,D and B(P<0.05)three,seven,14,21 and 28 days after transplantation,as well as grip strength 14,21 and 28 days after transplantation(P<0.05).The Edu/GFAP positive cells and Edu/MAP-2 pos-itive cells were found in both groups D and E.Conclusion Transplanting NSCs can promote the behavioral recovery after ischemic stroke, and it is more effective as pretreated with BDNF.

The spinopelvic alignment(SPA)closely relates to lumbar disease.This paper summarized various kinds of SPA parameters, introduced a new measure of computer motion analysis system.Most of patients with lumbar disc degeneration are found the lumbar lordo-sis decreasing,which indicates pelvic tilt and trunk anteversion.However,no obviously SPA varieties are found in patients with lumbar spi-nal stenosis and nonspecific low back pain.The SPA parameters can also be used as indices for evaluation of treatment for lumbar disease. Future researches may focus on selection of SPA parameters,noninvasive measurements,relationship to lumbar disease and application of SPA for evaluation of interventions.

The anticipatory postural adjustments can be more precise in reflecting the ability of posture control,which associate with two kinds of neuromuscular model.Anticipatory postural adjustments disorders are found in stroke patients with hemiplegia,such as delay of muscle activation time,decrease of muscle activation,degradation of muscle recruitment order and reduction of adaptability.

Objective To develop a upper limb motor function rehabilitation system based on somatosensory interaction technique,and test the work of assessment module.Methods A 3D rehabilitation game system was developed based on the skeletal tracking of Kinect and Unity3D.Five subjects were trained with four actions commonly used for upper limb rehabilitation with the trajectory guidance or without, and were evaluated with the system.Results The scores of all the actions were more with the trajectory guidance than without.Conclusion Upper limb rehabilitation training game system has been developed based on Kinect, which can guide patients for rehabilitation training through trajectory guidance and assess the outcome of rehabilitation quantitatively.

Objective To observe the effect of horticultural training based on healing garden as rehabilitation for post-operation of hand trauma.Methods From January,2015 to December,2016,78 patients with functional disorder after operation for hand trauma were random-ized into control group and observation group equally.All the patients accepted routine rehabilitation,while the observation group accepted horticultural training based on healing garden in addition,for 28 days.They were assessed with Total Active Movement(TAM),Disability of Arm Shoulder and Hand(DASH),and Upper Extremity Function Test(UEFT)before and after treatment.Results The scores of TAM, DASH and UEFT improved in both groups after treatment(t>10.632,P<0.001),and improved more in the observation group than in the con-trol group(t>2.269,P<0.05).Conclusion The horticultural training based on healing garden may promote the recovery of movement of fin-gers,function of hand and upper limbs in patients after hand trauma.

Objective To compare the effect of Shaker exercise and Chin Tuck Against Resistance(CTAR)exercise on dysphagia after radiotherapy for nasopharyngeal carcinoma(NPC).Methods From August,2015 to February,2017,90 patients with dysphagia after radio-therapy for NPC were randomly divided into control group,Shaker group and CTAR group equally.The control group received routine swal-lowing training,while the Shaker group accepted Shaker exercise and CTAR group accepted CTAR exercise in addition.They were assessed with Penetration-Aspiration Scale under video fluoroscopic swallowing study(VFSS)before,and two weeks,four weeks and six weeks af-ter exercise.Results There was no significant difference in VFSS score among the three groups before intervention(F=0.551,P>0.05).The score decreased after intervention in Shaker group and CTAR group(F>5.317,P<0.001),but varied less in the control group(F=1.774,P>0.05).However,it was less in Shaker group and CTAR group than in the control group(P<0.001),and it was not significantly different be-tween Shaker group and CTAR group after 4 weeks and 6 weeks of intervention (P>0.05).The total effective rate was 86.67% in CTAR group and 76.67% in Shaker group,that was significantly higher than 43.33% in the control group(χ2>2.079,P<0.05),and it was not signifi-cantly different between Shaker group and CTAR group(P>0.05).Conclusion CTAR exercise is effective on dysphagia after radiotherapy for NPC,which is similar to those of Shaker exercise,and more acceptable and easier to persist.

Objective To investigate the relationship between the single nucleotide polymorphisms(SNP)of rs11706903,intron region of Atg7,and Parkinson's disease(PD).Methods From January,2013 to March,2017,130 PD patients and 109 healthy subjects were recruit-ed and collected the blood samples.SNPs of rs11706903 were detected with polymerase chain reaction restriction fragment length polymor-phism.Results For the patients,the genotype frequencies of rs11706903 were AA 10.00%,AC 52.31% and CC 37.69%;and allele frequen-cies were A 36.15% and C 63.85%.For the healthy controls,the genotype frequencies of rs11706903 were AA 7.34%,AC 49.54% and CC 43.12%;and allele frequencies were A 32.11% and C 67.89%.There was no significant difference in frequencies of genetypes and alleles be-teen two groups(χ 2<1.001,P>0.05).Conclusion There might be no relationship between SNPs of Atg7 intron region rs11706903 and PD.

Objective To investigate the correlation between residual strength of neck and shoulder muscles and respiratory function in patients with cervical spinal cord injury.Methods From January,2015 to June,2016,the muscle strength of sternocleidomastoid,trapezius and deltoid was tested in 30 patients with cervical spinal cord injury five and 24 weeks after injury.Meanwhile,their neurological and pul-monary function was evaluated.Results There was correlation between the vital capacity and muscle strength of deltoid both five and 24 weeks after injury(r>0.806,P<0.05)in the patients intermittent without ventilation,and it was found in sense score five weeks after injury (r=0.914,P<0.01),motor score(r=0.979,P<0.001)and the muscle strength of trapezius(r=0.894,P<0.01)24 weeks after injury.Conclu-sion The residual strength of neck and shoulder muscles,especially of deltoid,plays an important role in the respiratory function in patients with cervical spinal cord injury.

Adolescent idiopathic scoliosis(AIS)is a complex three-dimensional spinal deformity,characterized by lateral curvature and vertebral rotation.The medical imaging techniques are essential for determination of severity of scoliotic spine, prediction of progression and assistance in the decision-making process of treatment for scoliosis, including radiograph, stereoradiography, computed tomography, magnetic resonance imaging and ultrasound.This paper reviewed their application from the view of measure parameters,reliability and va-lidity,as well as merits and demerits.It is possible to assess the three-dimensional nature of scoliosis in the future.