Objective This study was conducted to ascertain whether study on carcinogenic potential of reflux juice from long-standing gastrectomy patients could clarify the relationship between duodenogastric reflux and gastric stump cancer. Methods A total of 48 reflux juice samples(11 Billroth Ⅰ,37 BillrothⅡ)were employed in our study.Ames test and MTT proliferation assay were carried out to evaluate the mutagenicity and proliferative activity of aspirates, respectively. Results There was no difference in mutagenicity of the samples in respect of surgical procedures(P＞0.05). While Billroth Ⅱ samples exhibited stronger proliferative activity than Billroth Ⅰ samples(P=0.751),In addition, the proliferative activity well correlated with pH of aspirates(rs=0.73,P＜0.001),but the mutagenicity failed to this correlation. Conclusion We confirm the duodenal reflux theory for the gastric stump cancer with the aspirates from long-standing postgastrectomy patients, and further suggest that proliferative activity of aspirates should be responsible for the high incidence of gastric cancer in the long-standing gastrectomy patients, thus roviding direct evidence for the etiology of the gastric stump cancer. Simultaneously closely endoscopic surveillance or postgastrectomy patients with moderate/severe dysplasia is highly recommended. In addition, to decrease the incidence of stump cancer effectively, it seems reasonable to perform reconstruction procedures(e.g,Roux-en-Y anastomosis)for those with severe duodenal reflux and to focus the chemoprevention of this cancer on proliferative activity of the reflux juice.

Objective　In order to explore the prevalence of hypophosphatemia in postoperative patients of general surgery,as well as the time and dosage of phosphate replacement and its effects.Methods　To serum phosphate levels of 45 patients with phosphate replacement begun on the second postoperative day and 45 without replacement were monitored at the preoperative day,and the first,third,fifth and seventh postoperative day.Results　The incidence of hypophosphatemia was 91.1%(41/45) in cases without phosphate replacement.While it was 57.8%(26/45) in those with replacement.The serum phosphate concentrations in cases with phosphate replacement were higher than those without replacement on the third(P<0.001),fifth(P<0.05) and seventh(P<0.01) postoperative day.The Apache Ⅱ scores in cases with phosphate replacement decreased on the third postoperative days compared with those on the first day(P<0.001).Conclusion　The postoperative replacement of phosplates can avert the occurrence of hypophosphatemia and improve the Apache Ⅱ score.

Objective　This study was To investigate the incidence rate of Cockett syndrome and relationship between Cockett syndrome and varicose veins and deep venous incompetence of the left lower extremities.Methods　73 patients(100 legs) with varicose veins of the lower extremities were investigated by descending deep venography and iliography preoperatively.Results　There were 35(47.9%) cases with abnormalities of the left common iliac vein (ALCIV)in all the cases.There were 31 cases with this conditions in the patients with varicose veins of the left or both lower extremity.While in the patients with varicose veins of the only right lower extremity,there were only 4 cases with ALCIV.In contrast,there was a significant difference between groups(χ2=9.8641,P=0.0017).In the patients with ALCIV,14 cases with Ⅲ or Ⅳ grade of deep venous incomptence were found, and only 6 cases with deep venous incompetence in the patients without ALCIV.There was a significant difference(χ2=5.3688,P=0.0205).Conclusion　Cockett's syndrome frequently occurs in varicose veins of the left lower extremity.There is a relationship between them.Cockett's syndrome might be one of the causes for the deep venous incompetence of the left leg.

Objective　To discuss the technique,advantages and follow-up results of subfascial endoscopic perforator surgery.Methods　Subfascial Endoscopic Perforator Surgery was performed for 23 patients wth chronic venous insufficiency.Over two years postoperative follow-up was done.Results　21 in 23 cases with ulcers healed.Only one case had wound infection.Conclusion　Subfascial Endoscopic Perforator Surgery is a safe and effective procedure in treating venous insufficiency.

Objective　To evaluate adbomen surgery in patients who are found to have poorly controlled or untreated hypertension before operation.Methods　From January 1997 to December 1998,the perioperative clinical data of 531 patients with hypertension and undergoing abdomen surgery in our hospital were retrospectively analyzed.Results　The incidences of perioperative hypertensive events were not significantly different,between controlled and uncontrolled patients with grade one and grade two (P>0.05).In grade three and systolic hypertension,certain perioperative complications in patients with poorly controlled hypertension were higher than in those with well-controlled hypertension(P<0.05).Conclusion　The patients with grade on e and grade two hypertension are not at increased operative risk.In Patients with grade three and systolic hypertension,perioperative complications are increased and elective surgery should be postponed until their blood pressure is brought under 180/110 mmHg over 1 to 2 weeks.

Objective To study how to reduce the incidence rate of skin flap necrosis after the eradicative resection of breast cancer. Methods 45 patients with breast cancer underwent eradicative operation with new methods to prevent the necrosis of skin flap,and they were studied and compared with 1210 cases treated by traditional ways. Results With the new methods adopted, the necrosis rate of skin flap following eradicative operation of breast cancer was reduced from 45%(original)to 2%(present).Statistic analysis showed that there was outstanding difference between them. Conclusion In the eradicative operation of breast cancer,the key to prevent the necrosis rate of skin flap is:prevention of subaxillary lymphatic fistula, two tubular drainage set individually in subcostalis and subaxillaris, appropriate force of chest bandaging, proper thickness of skin flap and perfect suture without tension.

Objective The purpose of this study was to determine the indication,methods,safety and efficacy of hepatic resection for metastatic carcinoma of the liver. Methods Sixty-nine consecutive hepatic resections in 67 patients with secondary carcinoma of the liver were reviewed. Results One case died and operative mortality rate was 1.5 %.Median follow-up was 5 years, ranging from 1 to 7 years. The 1、3、5-year survival rates for all patients were 28.36%、 19.40% 、and 11.94% respectively. The survival rate of over 5-years in the hepatic resection for metastatic colorectal carcinoma was 21.43%. Conclusions Surgical resection of metastatic disease to liver is not only safe but also curative. We recommend that for any patient with metastatic carcinoma of the liver, an anatomic distribution of tumors to preserve hepatic function after resection and fitness to withstand the procedure should be considered for resection.

Objective To understand the effect of the resect margin(RM)to hepatectomy for primary hepatocellularcarcinoma(PHC).Methods In 544 cases,72 cases were small PHC(≤3cm),473 cases were large PHC(＞3cm). Four groups were classified according to the distance of RM The 5-year recurrence rate and survival rate after hepatic resection in each group were analyzed. Results RM with residue cancer or cancer embolus had a high 5-year recurrencre rate and lower survival rate in both small and large PHC. Small PHC with RM≥1.0cm and large PHC with RM≥2.0cm had higher 5-year survival rate and lower recurrence rate. Conclusion We recommend RM≥1.0cm for smallPHC and RM≥2.0cm for large PHC.

Objective To investigate the causes,diagnosis and treatment of postoperative acute cholecystitis. Methods Clinical data of 9 cases with postoperaive acute cholecystitis were analyzed retrospectively. Results7 cases was confirmed by ultrasonography, 1 case was confirmed by CT, and 1 case died of gallbladder perforation, no operative mortality in emergency cholecystectomy. Conclusion The prevalent etiology is biliary stasis. Early diagnosis and treatment is the key point to decrease the death rate.

Objective To improve the level of diagnosis and treatment of the sharp injury in the back. Methods 47 cases which were treated from Jan 1991 to May 2000 were reviewed. ResultsAmong 37 cases who underwent the exploration, 5 cases died. Among 10 cases who underwent conservative treatment, 2 cases died. ConclusionThe condition of sharp injury in the back is very complicated,it is easy to be misdiagnosed, the mortality is high. Saving should be equalled with the diagnosis and treatment. The application of wound exploration, abdominal puncture, ultrasound examination and X-ray checking is valuable to the diagnosis. The patients with operation indications should be operated at once,while the others should be observed for some time to prevent the delayed clinical manifestation.