To evaluate the efficacy of interferon inhalation by PARI inhaler boy with bronchiolitis, 110 children were randomly divided into two groups. Group 1 included 64 cases who received interferon inhalation by PARI inhaler boy(made in Germany) and the other 46 patients who didn' t received interferon by PARI inhaler boy served as group 2. The effects were compared between the two groups in term of wheezing rale disappearance time, rale absorbing time and hospital stay time. Our results showed that wheezing rale disappearance time in group 1 was shorter than that in group 2( t = 6. 143, P＜ 0.01 ); rale absorbing time in group 1 was significantly shorter than that in group 2 ( t = 2.03, P＜0.05); hospital stay time in group 1 was significantly shorter than that in group 2( t = 3. 195, P＜0.0). It is concluded that interferon inhalation by PARI inhaler boy is an effective auxiliary treatment forbronchiolitis.

Objective:To evaluate the efficiency and safety of fraxiparin in the treatment of patients with ACS. Method:137 patients with acute coronary syndrome(ACS)were randomly assigned to fraxiparin treatment and enoxaparin treatment for 7 days.Result:129 cases completed the whole trial and the results were obtained from ITT.The heart death rate was not statistically different between the two groups during the treatment.No Q segment acute myocardial infarction occurred.Both drugs statistically decreased CK CKMB and TnT.There was no significant difference between the two groups regarding these changes.Only two minor adverse reactions occurred and became normal soon after nadroparin withdrew. Conclusion:Fraxiparin and enoxaparin had similar efficiency and safety in the treatment of patients with ACS.

In order to get information on the use of antibiotics in rural areas, 300 hospitalized patients were randomly selected from a rural hospital of Guangdong province and investigated for antibiotic use. The rate of antibiotic use in the hospitalized patients was 86.7 %; the four antibiotics at the top of the list were penicilins, cephalosporins, quinolones and macrolide. The rate of combined use of antibiotics was 68.46%. The culture of bacteria was carried out in only 4.62% of the patients and no antimicrobial susceptibility test was conducted. It is concluded that the antibiotics were not used in rational fashion in the rural hospital.

To investigate the use of antibiotics in the patients with non-Helicobacter pylori (Hp)peptic ulcer, 487 patients of 3 hospitals were analyzed retrospectively. Our results showed that in the 487 cases, the antibiotics were used in 44.3% of the patients. Among them, 56.5 % of the patients were not indicated for the use of antibiotics. There was a significant difference between patients on Free Medical Care Program and non-free-medical care program patients(P＜0.001 ). No significant difference was found in the use of antibiotics between Class lA and Class 2A hospitals( P＞0.05 ). It is concluded that increasingly serious and extensive abuse of antibiotics exists in the treatment of peptic ulcer and steps should be held in check.

To investigate the short and long-term effects of intensive cyclophosphamide therapy plus corticosteroids on lupus mephritis, 27 patients with severe lupus nephritis were divided into two groups. Patients in group 1 received prednisone alone and patients in group 2 were given intensive cyclophosphamide therapy plus corticosteroids. The treatment course lasted for 1.5 years and the patients were followed up for 4 years. At the end of the treatment, the differences in indicators, single or comprehensive, of effieacy were statistically signifieant(P＜0.05) between the two groups. A four-year follow-up showed that the difference in relapse was significant(P＜0.05). It is concluded that the intensive cyclophosphamide therapy plus corticosteroids on lupus nephritis was better than that of predinison-alone treatment in our series in terms of short-term and long-term effects on lupus nephritis.

To evaluate the therapeutic effect of INF on mumps encephalitis in children, 86 eases of mumps encephalitis wererandomly divided into two groups in order to compare the effects of INF and that of rihavirin. The recovery time of fever was 2.1± 0.52 days. The recovery time of parotid gland enlargement was 3.5±0.82 days. The recovery time of nervous system symptoms was 1.62±0.75 days. The comparison showed that the therapeutic effects of IFN was superior to that of ribavirin(P＜0.05).

To get information about the status of use of oral hypoglycaemic agents in an inland and coastal hospitals,the ordes of total cost and DDDs were employed to compare the use of oral hypoglycaemic agents in an inland hospital and a coastal hospital.Our results showed that the much less biguanides were used in the coastal hospital as compared with the inland hospital.It is conclinical practice included dimethyl biguanide,glipizide,gliclazide and glibenclamide.

To find out the patterns and trend of clinical use of antihypertensive agents to provide a guidance for rational use of drugs, the antihypertensive drugs used in our hospital during 1995-1999 period was investigated in respect to the sum of consumption cost, drugs used and DDDs. Our results showed that the DDDs and the consumption cost for antihypertensive drugs have increased gradually for recent 5 years. The order of DDDs of drugs was as follows: calcium antagonists, adrenergic blocking drugs, ACE inhibitors, the drugs affecting sympathetic transmitters and peripheral vasodilators. The order of sum of money was as follows: ACE inhibitors, calcium antagonists and calcium antagonists respectively. It is concluded that a diverse array of anthhypertensive agents were available and widely used clinically and attention should be paid to the rational use of the drugs.

To study the status and patterns of the drug utilization in the diseases of lower respiratory tract, the drug utilization for 290 inpatients with respiratory tract diseases in a Shanghai hospital druing 1993-1997 was analyzed by using Acute Physiology, Age, Chronic Health Evaluation(APACHE) and index of defined daily dose numbers(DDDs). The relativity between APACHE and DDDs was studied. It was found that most common drugs was anti-infection agents and expectorants, accounting for 39.06% and 38.38 %, respectively. The quantitative relationship between drug consumption and disease severity was not observed. It is concluded that the status of the drug utilization can't be demonstrated by analyzing the frequency of drug use by using DDDs.

To better understand the drugs, frequency and other factors involved in the drug-induced renal failure, 227 cases of renal failure reported in the Chinese medical and pharmaceutical journals were statistically analyzed. Our results showed that the drugs that tend to cause renal failure are antibiotics, involving 80 cases, followed by antituberculosis agents(38 eases)and dehydration agents. Gentamycin (47 cases) and rifrimactane(36 cases) were among the drugs with highest incidence. There were 58 cases of death due to drug-related renal failure.