Objective:To study the protective effects of Shenmai injection (SMI,参麦注射液) on peritoneal mesothelial cell in rats with 5/6 nephrectomy. Methods:By using light microscopy and scanning electron microscopy the morpholgical structure changes of peritoneal mesothelial cell in rats with 5/6 nephrectomy caused (chronic)renal failure model of after the peritoneal didysis of SMI were observed at the same time the levels of C3 and IgG in peritoneal dialysate were observed also. Results:The SMI could promote the recovery and proliferation of injured peritoneal mesothelial cell increase the immunity function of abdomen in rats. Conclusions:The SMI has protective effect on peritoneal cell in rats with 5/6 nepherctomg the protecive effect related to improving regional defence function in abdomen.

Objective:To study the pathogenetic mechanism of intestinal injury in the aged rat with pneumonia and the effect of Dusuqing(毒素清) on it.Methods:The models of rats with Escherihia coli pneumonia were duplicated and divided into aged control group(ACG),aged model group(AMG),high doses group(HDG) and low doses group(LDG) of Dusuqing and norfloxacin group.The pathological changes in lung tissue and intestine,the contents of intestinal 6-keto-prostaglandim F1α(6-keto-PGF1α),thromboxane B2(TXB2),nitride oxide(NO),malondialdehyle(MDA) and the activity of superoxide dismutase(SOD) were observed.Results:The lung and intestinal injury in AMG was more serious.The decrease of SOD activity and 6-keto-PGF1α content,the increase of content of TXB2,NO,MDA in the AMG were more significant than those in the ACG.In comparison with those in the AMG,the level of SOD activity,6-keto-PGF1α content were increased,otherwise the contents of MDA and NO were decreased in the HDG,the LDG and the norfloxacin group.Conclusions:The injury mediated by prostaglands and free radical is related to the occurance and development of damage of intestinal tissue with pneumonia. Dusuqing is able to improve this damage obviously in aged rats with pneumonia and the mechanisms and regulation of prostaglands metabolism.

Objective:To observe the dynamic changes in serum gastroanteric hormones in patients with stroke complicating stress upper gastrointestinal hemorrhage in acute stage,the changes in acidity,and the changes in gastric empty and to investigate the pathogenetic link of stress pathological change of gastric mucous membrane in patients with stroke(Zhongzangfu,ZZF,中脏腑).Methods:In 20 cases with acute ZZF (Glasgow coma score 6-12 scores) who were all complicating upper gastroenteric bleeding within 24 hours of attack,the levels of motilin(MTL),somatostation(SS),and gastruins(GAS) were measured by radioimmunoassay at the first day (within 24 hours) and the fourth day (within 72-96 hours) respectively meanwhile the gastratube was plased and kept within 24 hours of attack to dynamically observe the pH of gastric juice and the condition of gastric emptying.Results:In comparison with control group the MTL level was significantly increased in patients at the first day of attack (P<0.05),the SS level significantly decreased (P<0.01),and the GSA level had not significant difference (P>0.05).Otherwise the pH (2.87±0.90） of gastric juice in comparison with control group has not significant difference (P>0.05).Among patients in 17 cases the gastric emptying time was prolonged.Even at the fourth day in patients the MTL level was still significantly increased (P<0.01),SS level decreased (P<0.05),and GAS level increased (P<0.01).Conclusions:The upper gastrointestinal hemorrhage in patients with acute ZZF is tightly associated with the changes in MTL and SS but the changes in GAS and gastric pH are not main factor.

Objective:To study the influence of astragalus injection(黄芪注射液) plus Shenmai injection(参麦注射液) on each stage of hemorrhagic fever with renal syndrome(HFRS).Methods:Thirty-six cases with HFRS were randomly divided into treated group(n=19) which was treated with western medicine and traditional Chinese medicine (astragalus injection and Shenmai injection) and control group (n=17) which was treated with western medicine alone during fever stage.The curative effects were compared.Results:In treated group the rates of over hypotensive shock stage and over oliguria stage were both 94.74％ ,they were significantly heigher than those in control group(both P<0.05).The prolonged times of polyguria,increased blood urea nitrogen(BUN),and proteinuria in treated group were significantly shorter than those in control group (all P<0.01).Conclusions:The astragalus injection and Shenmai injection possess the ability to enhance the antidisease capability in patient with HFRS and are able to shorten the shock stage,to reduce the occurance rate of oliguria,to shorten the duration of each stage,and finally to shorten ill course and promote the patients to recovery as early as possible.

Objective:To study the influences of astragulas(黄芪) on cerebroischemiareperf usion injury in gerbils.Methods:The cerebral tissue delayed neuron death(DND) models of gerbil were established by means of ligating bilateral carotid arteries for 15 minutes then reperfusing for 48 hours and divided into shamoperation(SO) group,ischemiareperfusion(IR) group and astragulas injection (AI，黄芪注射液) group.The activities of Na ＋K＋ATPase and nitric oxide synthase(NOS) and the changes in contents of nitric oxide(NO) and excitat ory amino acid(EAA) in cerebral tissue were compared in different groups.Results:(1)In comparison with SO group the activities of Na＋K＋ATPase in IR and AI group were obviously decreased furthermore the decreases in IR group were mo re significant than those in AI group(all P<0.01).(2) The changes in co nten ts of lactic acid(LD) in cerebral tissue in all the groups had not statistically significance.(3)In comparison with SO group the activitis of NOS and the conten ts of NO in IR and AI group were reduced but the reductions in IR group were muc h more significant (P<0.05).(4)The contents of glutamic acid(Glu) in IR and AI group were higher than those in SO group and the increases in IR group w .05),meanwhile they in IR group were higher than those in AI group but the di fference was not significant.(6)Among all the groups the contents of γam inobutyric a cid (γGABA) and glycine(Gly) had not significant differences (all P>0.05).Conclusions:The mechanisms of astragulas on anticerebral ischemiareperfusion inj ury may be related to its preventing the reductions of activities of Na＋K ＋ATPase,NO S,and the decreases in synthetic volume of NO as well as its heightening the con tents of EAA after ischemia of brain tissue.

Objective: To study the therapeutic method of treating hypertensive cerebral hemo rrhage and to evaluate the curative effects.Methods: Thirtynine cases (A group) with hypertensive cerebral hemorrhage wer e treated wit h therapeutic method of internal medicine and other 40 cases (B group) treated with internal medicine combined with traditional Chinese herbs fed via gastric tube plus drawing hematoma through skull pun cture.Results:The cured rate (32.5%) and effective rate (90.0%) in B group were signific antly higher than those in A group (10.3％ and 46.2％ respectively) meanwhil e the complete obsorbsion and clearan ce time of hematoma were significantly shorter,and the complications were lesse r.Conclusions:The therapeutic method of traditional Chinese herb fed via gastro tube combined with drawing through skull puncture for treating hypertensive cere bral bleeding is easy to manipulate and worth spreading.

Objective: To observe the clinically curative effect of Jiangtong Xifeng liquid (JTXFL,降通 熄风液)combined with conventional therapy of western medicine on acute cerebral hemorrhage.Methods:Ninety cases were randomly divided into 2 groups.The treated group (n=60) was treated by JTXFL combined with conventional therapy of western medicine.The control group (n=30) was treated with conventional therapy alone.Before an d after therapy the changes in scores of neural functional defect,state of cons ciousne ss,blood pressure,and CT and the curative effects were observed for both groups.Results:The total effective rate was 88.3% in treated group,but it was 76.7% in contro l group, so that it in treated group was significantly superior to that in contr ol group (P<0.05). Conclusions:The curative effects of JTXFL combined with conventional therapy of western med icine on acutely cerebral hemorrhage is very obvious.

Objective: To investigate the effects of Pingzhi Jianxin tea(平脂健心茶) on treating hyperl ipaemia and its mechanisms.Methods:One hundred and twenty cases with hyperlipaemia were randomly divided into trea tme nt group and control group, the treatment group was treated with Pingzhi Jianxin tea and the control group was t reated with gingko nut leaf tablet.The curative effects between two groups were compared.Meanwhile, experimental study on animal model of hyperlipaemia was conducted.Results:The total effective rates in depressing blood lipids and viscosity in treatment group was 92.5% and in control group was 72.5%.The total effective rates in electrocardiogram improvements were 65.5% and 56.3% respectively.The difference between two groups was significant(P<0.01 and P<0.05)． In experimental study the blood lipid of hyperlipaemia rats was reduced after taking Pingzhi Jianxin tea and this action in treatment group was superior to that in control group (P<0.01). Conclusions:The curative effects of Pingzhi Jianxin tea on treating hyperlipaemia and improving myocardial ischemia are confirmed and if used for a long time there is not harmful effect.

Objective:To observe the curative effects and the influences of Yueanxin injection (YAXI, 悦安欣注射液) on acute cerebral infarction (ACI) and on blood rheology separately. Methods:Sixtytwo cases with ACI were randomly divided into treated group ( n=31) which was treated with YAXI and control group (n=31) which treated with tetrameth ylp yrazine injection (川芎嗪注射液) as control. Once a day for 30 days as a therape utic course to both groups.The curative effects and the changes in blood rheology parameter s were observed.Results:The marked effective rate (74.2%) and total effective rate (96.8%) in treated g roup were significantly superior to those (38.7% and 67.7% respectively) in cont rol group (P<0.05 or P<0.01). The improvements of blood rheology param eters in tr eated group were significantly better than those in control group (P<0.0 5 or P<0.01).Conclusions:The curative effects of YAXI on ACI are sufficient.

To investigate the mechanism of Xiefei Dingchuan injection (XFDCI,泻肺定喘注射液) in treating pulmonary hypertension by means of measuring the activity of Ca2＋Mg2＋ ATPase and Na＋K＋ATPase of red blood cell(RBC) membrane.Methods:The pulmonary hypertension models induced by monocrotaline in 18 rats were established then treated with XFDCI.Using cardiac catheter and chromatometry respectively the pulmonary artery pressure (PAP) and the activities of Ca2＋Mg2＋ATPase and Na＋K＋ATPase of RBC membrane were measured.Results:The activities of Ca2＋Mg2＋ATPase and Na＋K＋ATPase of RBC membrane in XFDCI group were obviously higher than those in pulmonary hypertension group.Conclusions:XFDCI is able to reduce the pulmonary hypertension and its mechanisms may be related to increasing the activities of Ca2＋Mg2＋ATPase and Na＋K＋ATPase of RBC membrane.