Ectodermal dysplasia tends to fall into two groups, the hidrotic and anhidrotic fo rms. Each type has a seperate geneologic origin and distinct clinical manifestation. The hidrotic form usually results from the action of an autosomal dominant gene, whereas the anhidrotic form appears to be deterrnined by the action of a sex linked recessive gene. In the hidrotic form the main clinical manifestations are dystrophic nails, defects of hair shaft and hyperkeratosis of the palms and soles. Recently one case with dystrophic nails, defects of hair and eyebrow and normaI sweating function without family history has been seen by us.
Ectoderm* ; Ectodermal Dysplasia ; Eyebrows ; Genes, Dominant ; Genes, Recessive ; Hair ; Humans ; Sweat ; Sweating

Two cases of inetastatic tumor of the skin were reported with literature review. One case, aged 67 years male, had a seven year history of multiple nolular lesions On the abdorninal wall. Histopathological findings were compatible with adenocarcinoma. Other case, aged 57 years male, who had a episode of subtotal gastrectomy, under dingnosis of stomach cancer four years ago, had a one and half year history of multiple nodular lesions on the face. Histopathological findings were compatible with fibrosis at first biopsy but confirmed with undifferential carcinoma after five months, These metastatic tumors of the skin were considered to be originated from the stomach in view of clinical and histopathological findings.
Adenocarcinoma ; Biopsy ; Fibrosis ; Gastrectomy ; Humans ; Male ; Skin* ; Stomach ; Stomach Neoplasms

Psoriasis vulgaris is a common skin disease usually affects the traumatic joints and scalp in young adult. I reviewi 14l6 patients and the results were as follows; 1. Sex incidence was 991 in male and 425 in female(2.3: 1). 2. The peak age at onset of disease was between from 11 to 80 year of age. 3. The onset of psoriasis showed higher incidence in summer and lower in autumn. 4. Sites affected by psoriasis were most frequent in elbow joint(31.8%), 5. Koebner Phenomenon was found in 12.9% and the incubation period was 16 days on the average. 6. Family incidence was found in 198 cases(13.9%). 7. Joint pain was associated in 155 cases(10.9%), mainly in knee joint. 8. Nail involvement was in 84 cases(5.9). 9. Mucous membrane involvement was in 103 cases(7. 2% ). 10. Other skin diseases in those study were variable but the predominated in neurodermatitis, ll. A significant difference between man and woman for the medication, man was treated by specialist while the woman was medicated by pharmacist advised 12. Approximately half of the cases(56.6%) were ignorant for psoriasis. 13. A significant difference between man and woman about psychiatric problem, was observed. The man had a sought of incurability while the woman had anxiety for the life threaten.
Anxiety ; Arthralgia ; Elbow ; Female ; Humans ; Incidence ; Joints ; Knee Joint ; Male ; Mucous Membrane ; Neurodermatitis ; Pharmacists ; Psoriasis* ; Scalp ; Skin Diseases ; Specialization ; Young Adult

The association of varicose vein, soft tissue and bony hypertrophy and. cutaneous hemangioma of the "port-wine" variety confined to one extremity was first reported in l900 by Klippel and Trenaunay, and then Weber. Their reports are generally considered today represent variations of the same syndrome. The vascular abnormalities may be any type of hemangioma, arteriovenous fistula, or lymphangioma appearing at birth or in infancy. The trophic changes almost always involve only one limb. The authors reported a case of Klippel-Trenaunay-Weber(K-T-W) syndrome in seven- year-old boy consisted of nevus flammeus associated with hypertrophy, elongation and heating sensation except varicose or arteriovenous fistula of the left leg.
Arteriovenous Fistula ; Brain Stem Infarctions* ; Extremities ; Heating ; Hemangioma ; Hot Temperature ; Humans ; Hypertrophy ; Leg ; Lymphangioma ; Male ; Parturition ; Port-Wine Stain ; Sensation ; Varicose Veins

Letterer-Siwe disease in an acutely onset, progressive and fatal disorder of RES, usually appears in male children, chareacterized by constitutional signs and extraos-seous lesions. This case occurred in a 18-day-old female showing hepatomegaly, hemorrhagic crusted papular eruptions on the entire body, and abdominal distension. Direct smear of scraping materials from the skin lesion showed numerous histiocytes. Hematologic and other laboratory examinatons showed no abonormalities.
Child ; Female ; Hepatomegaly ; Histiocytes ; Histiocytosis, Langerhans-Cell ; Humans ; Male ; Skin

To take advantage of hypertrichosis, one of the side effcct of minoxidil, is used as a application to male pattern baldness and alopecia areata. Recently 101 Hair Regrowth Liniment which is a new hair growth stimulator from China is used in male pattern baldness, but its components, actions and side effects are exactly unknown. We experienced three cases of allergic contact dermatits one case due to minoxidil and others due to 101 Hair Regrowth Liniment which were confirmed by patch test.
Alopecia ; Alopecia Areata ; China ; Dermatitis, Allergic Contact* ; Hair* ; Hypertrichosis ; Minoxidil ; Patch Tests

Bowen's disease may be defined as an intraepidermal squamous cell carcinoma of the skin whieh puraues a slow, relatively benign course but may progress into invasive carcinoma. We have experienced two female patients who had well demarcated, multicentric, brown to black colored flat-topped papules on the vulva with histopathologic features of intraepidermal squamous cell carcinoma but showed entireIy different clinicaI appearance from Bowen's disease. For differentiation from extramammary Paget's disease, PAS stain and mucicarmine stain were done but not reacted to them, Both cases were diagnosed as multicentric pigmented Bowen's disease, and in case 2, regression occured after local appIication of 5-fluorouracil cream. A conservative approach to managment of these lesions is suggested. We have experienced peculiar entities and literatures were reviewed.
Bowen's Disease* ; Carcinoma, Squamous Cell ; Female ; Fluorouracil ; Humans ; Paget Disease, Extramammary ; Skin ; Vulva

Pretibial myxedema, which consists of localized cutaneous accumulations of acid mucopolyeaccharides, occurs in a small percentage of patients with diffuse toxic goiter. Pretibial myxedema may also occur during the course of nonthyrotoxic thyroid disease. A case of pretibial myxedema with diffuse toxic goiter in 64 year-old female is reported. She has been suffered from thickened yellowish waxy pIaques on both pretibial areas and left dorsum of foot. Initial skin lesions developed about 7 months ago, and increased its size and numbers insidiously. Diagnosis was confirmed by characteristic clinical, laboratory and histopathological findings. Literatures were reviewed.
Diagnosis ; Female ; Foot ; Goiter* ; Humans ; Middle Aged ; Myxedema* ; Skin ; Thyroid Diseases

This study was performed in order to explore the immunologic relationship between the skin lesions induced by the human serum and the lymphatic organs. For these purposes, the authors induced the dermatitis in the rabbits by the injections of pooled human serum with Freunds complete adjuvant into the skin, and administered prednisolone and azathioprine as immunosuppressive drugs to the rabbits. Immunologic asmy was performed by the measurement of the plasma ceIls and immunogobulin-bearing B lymphocytes in lymph node and spleen. The results were as follows: 1. By the injections of human serum pyroninophilic cells and immunoglobulining B lymphocytes in lymph node and spleen were increased. 2. By the administrations of prednisolone and azathioprine, pyroninophilic cells and immunoglobulin-bearing B lymphocytes in lymph node and spleen were all decre RSCd.
Azathioprine ; B-Lymphocytes ; Dermatitis* ; Humans ; Immunoglobulins ; Lymph Nodes ; Plasma ; Prednisolone ; Rabbits* ; Skin ; Spleen

A 4-year-old boy have had widespread, multiple, dark brownish, verrucous ]papular plaques on the neck, left chest, right side of abdomen, back and penile skin since birth. Clinical features and light and electron microscopic findings were consistent with ichthyosis hystrix. The patient was successfully treated with systemic administration of etretinate and vitamin E.
Abdomen ; Acitretin* ; Child* ; Child, Preschool ; Etretinate* ; Humans ; Ichthyosis* ; Male ; Neck ; Parturition ; Porcupines* ; Skin ; Thorax ; Vitamin E ; Vitamins