No abstract available.

We experienced two cases of Gaucher's disease of adult type in brother aged four years and two years. The patients showed hepatosplenomegaly with anemia and thrombocytopenia. Typical Gaucher cells were found in bone marrow and biopsy specimens of liver and spleen through light and electron microscopic examination. Splenectomy was followed by improvement of anemia and thrombocytopenia. A brief review of literature was made.
Adult ; Anemia ; Biopsy ; Bone Marrow ; Gaucher Disease* ; Humans ; Liver ; Siblings* ; Spleen ; Splenectomy ; Thrombocytopenia

No abstract available.
Colon*

No abstract available.
Colon* ; Diverticulitis* ; Laparoscopy*

No abstract available.
Audiometry, Speech* ; Otitis Media* ; Otitis*

No abstract available.
Child* ; Humans ; Infant*

No abstract available in English.
Chondrosarcoma, Mesenchymal

Takayasu's arteritis is a chronic, granulomatous, large-vessel arteriopathy of unknown cause. A 45-year-old women developed multiple subcutaneous nodules preceded by fever, chills, weakness and weight loss. There were several developed pyoderma gangrenosum-like ulcerations which resulted from the breakdown of subcutaneous nodules on both forearms. A skin biopsy specimen from a forearm nodule revealed characteristics of polyarteritis nodosa including necrosis of the muscular arteries of the deep dermis and subcutaneous tissues destruction of the elastic lamella, thrombus formation, and an acute and chronic inflammatory cell infiltrates. Seven years later, the diagnosis of Takayasu's arteritis was suggested by the absence of the left radial pulse and confirmed by angiography.
Angiography ; Arteries ; Biopsy ; Chills ; Dermis ; Diagnosis ; Female ; Fever ; Forearm ; Humans ; Middle Aged ; Necrosis ; Polyarteritis Nodosa* ; Pyoderma ; Pyoderma Gangrenosum ; Skin ; Subcutaneous Tissue ; Takayasu Arteritis* ; Thrombosis ; Ulcer ; Weight Loss

A 60-year-old woman who had experienced two episodes of amaurosis fugax in her right eye presented with vision loss. Two weeks earlier, at a private clinic, she was diagnosed with impending central retinal vein occlusion (CRVO) of the right eye and received an intravitreal injection of bevacizumab. Two weeks after this injection she was diagnosed with ischemic CRVO. At 11-weeks post-presentation, extremely ischemic features were observed with fluorescein angiographic findings of severe vascular attenuation and extensive retinal capillary obliteration. At 22-weeks post-presentation she was diagnosed with neovascular glaucoma; she experienced no visual improvement over the following several months.
Antibodies, Monoclonal/*administration & dosage ; Disease Progression ; Female ; Fluorescein Angiography ; Glaucoma, Neovascular/complications ; Humans ; Injections, Intraocular ; Ischemia/diagnosis/*etiology/physiopathology ; Middle Aged ; Retinal Vein Occlusion/*complications/*drug therapy/physiopathology ; *Retinal Vessels ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Visual Acuity/drug effects ; Vitreous Body

PURPOSE: To evaluate the effects of oxidative stress and antioxidantson heme oxygenase-1 (HO-1) in cultured human retinal pigment epithelial (RPE) cells. METHODS: Cultured RPE cells were challenged with different concentrations of hydrogen peroxide (H2O2), and the HO-1 mRNA level was determined by RT-PCR after 24 hours and 48 hours of incubation independently. Additionally, the HO-1 mRNA level was measured after preincubating RPE cells with N-acetylcystein (NAC) as the antioxidant for 30 minutes and then challenging the cells with H2O2. RESULTS: The expression of the HO-1 mRNA level increased after H2O2 exposure, and this level was proportional to the increased H2O2 concentration (p<0.05). Expression of the HO-1 mRNA level decreased when the RPE cells were preincubated with NAC (p<0.05). CONCLUSIONS: In human RPE cells, the HO-1 level increased in proportion to the degree of oxidative stress and decreased with exposure to antioxidants. Expression of HO-1 may be helpful in preventing retinal disease, which occurs due to oxidative stresses such as age-related macular degeneration.
Antioxidants ; Heme ; Heme Oxygenase-1 ; Humans ; Hydrogen Peroxide ; Macular Degeneration ; Oxidative Stress ; Retinal Diseases ; Retinal Pigment Epithelium ; Retinaldehyde ; RNA, Messenger