1.Corrigendum: Effects of Macrolide and Corticosteroid in Neutrophilic Asthma Mouse Model.
Tai Joon AN ; Chin Kook RHEE ; Ji Hye KIM ; Young Rong LEE ; Jin Young CHON ; Chan Kwon PARK ; Hyoung Kyu YOON
Tuberculosis and Respiratory Diseases 2018;81(4):350-350
In this article, the statement of ethical statement about animal experiment was omitted.
2.Current status of microbiome research in asthma and chronic obstructive pulmonary disease.
Byung Keun KIM ; Chin Kook RHEE ; Ji Ye JUNG ; Hye Ryun KANG ; Sang Heon CHO
Allergy, Asthma & Respiratory Disease 2016;4(5):321-327
Asthma and chronic obstructive pulmonary disease (COPD) are characterized by chronic airway inflammation resulting in airflow limitation. They include various phenotypes and endotypes in their disease entities. For that reason, they lack proper biomarkers and epoch-making progresses in treatment nowadays. Healthy airway has been believed to be sterile traditionally. However, with the help of nonculture sequencing techniques, researchers discovered that it is full of the commensal and symbiotic microbial flora. Therefore, microbiome has emerged as a possible biomarker and a clue to understand the pathogenesis of airway disease. Microbiome research in asthma has focused on the association between characteristics of microbiome, such as composition and diversity. However, now it refers to the role of microbiome, including Proteobacteria, in the development and pathogenesis of asthma and allergic diseases. Microbiome research in COPD has revealed its different composition according to the existence and severity of the disease. Also, differences in microbiome composition according to exacerbation state or specific treatment of COPD are reported. Therefore, many researchers pay attention to the possible role of microbiome as a biomarker or a treatment target in asthma and COPD. Herein, we review recent studies on microbiome research in asthma and COPD.
Asthma*
;
Biomarkers
;
Inflammation
;
Microbiota*
;
Phenotype
;
Proteobacteria
;
Pulmonary Disease, Chronic Obstructive*
;
Research Design
3.Phenotype of asthma-chronic obstructive pulmonary disease overlap syndrome.
The Korean Journal of Internal Medicine 2015;30(4):443-449
Many patients with asthma or chronic obstructive pulmonary disease (COPD) have overlapping characteristics of both diseases. By spirometric definition, patients with both fixed airflow obstruction (AO) and bronchodilator reversibility or fixed AO and bronchial hyperresponsiveness can be considered to have asthma-COPD overlap syndrome (ACOS). However, patients regarded to have ACOS by spirometric criteria alone are heterogeneous and can be classified by phenotype. Eosinophilic inflammation, a history of allergic disease, and smoke exposure are important components in the classification of ACOS. Each phenotype has a different underlying pathophysiology, set of characteristics, and prognosis. Medical treatment for ACOS should be tailored according to phenotype. A narrower definition of ACOS that includes both spirometric and clinical criteria is needed.
Anti-Asthmatic Agents/therapeutic use
;
Asthma/*complications/diagnosis/drug therapy/physiopathology
;
Bronchodilator Agents/therapeutic use
;
Humans
;
Lung/drug effects/*physiopathology
;
Phenotype
;
Predictive Value of Tests
;
Pulmonary Disease, Chronic Obstructive/*complications/diagnosis/drug therapy/physiopathology
;
Risk Factors
;
Spirometry
;
Syndrome
;
Terminology as Topic
;
Treatment Outcome
4.High prevalence of chronic obstructive pulmonary disease in Korea.
The Korean Journal of Internal Medicine 2016;31(4):651-652
No abstract available.
Korea*
;
Prevalence*
;
Pulmonary Disease, Chronic Obstructive*
5.A Rare Case of Angioleiomyoma Arising in the Subglottic Area to Upper Trachea of a Patient with Underlying Asthma.
Yeoun Eun SUNG ; Chin Kook RHEE ; Kyo Young LEE
Journal of Pathology and Translational Medicine 2017;51(1):92-95
Angioleiomyoma is a rare disease that is histologically characterized by smooth muscle cells arranged around vascular spaces. Although angioleiomyomas occur rarely in the head and neck region, they can cause various symptoms according the site involved. Here, we present a 44-year-old male patient with a 15-year history of asthma, who presented with recent onset of chest discomfort, globus sensation and throat pain. Medication was not effective in relieving his symptoms, and further evaluation revealed a polypoid ovoid mass, almost obstructing the airway at the border of the larynx and upper trachea on chest computed tomography. The mass was completely resected via a rigid bronchoscopy procedure. Histopathologic examination revealed that the excised mass was angioleiomyoma, which was immunohistochemically positive for smooth muscle actin and negative for desmin.
Actins
;
Adult
;
Angiomyoma*
;
Asthma*
;
Bronchoscopy
;
Desmin
;
Head
;
Humans
;
Larynx
;
Male
;
Muscle, Smooth
;
Myocytes, Smooth Muscle
;
Neck
;
Pharynx
;
Rare Diseases
;
Sensation
;
Thorax
;
Trachea*
6.A Case of Acute Fulminant Fat Embolism Syndrome after Liposuction Surgery.
Seong Wook BYEON ; Tae Hyun BAN ; Chin Kook RHEE
Tuberculosis and Respiratory Diseases 2015;78(4):423-427
Fat embolism syndrome (FES) is a clinical manifestation that consists of multiple organ dysfunction due to fat emboli. FES occurs as a complication after trauma or procedures such as surgery. The diagnostic criteria of FES have not yet been established, so clinical criteria are used for its diagnosis. The clinical course of acute fulminant FES can be rapid. Liposuction surgery, in which adipocytes are mechanically disrupted, is one cause of FES. As the number of liposuction surgeries increases, clinicians should be aware of the possibility of FES. This was the first report of a case of acute fulminant FES with severe acute respiratory distress syndrome after liposuction surgery, in Korea.
Adipocytes
;
Diagnosis
;
Embolism, Fat*
;
Korea
;
Lipectomy*
;
Respiratory Distress Syndrome, Adult
7.Strategies for Management of the Early Chronic Obstructive Lung Disease.
Jung Yeon LEE ; Chin Kook RHEE ; Ki Suck JUNG ; Kwang Ha YOO
Tuberculosis and Respiratory Diseases 2016;79(3):121-126
Lung function reportedly declines with age and that this decline is accelerated during disease progression. However, a recent study showed that the decline might peak in the mild and moderate stage. The prognosis of chronic obstructive pulmonary disease (COPD) can be improved if the disease is diagnosed in its early stages, prior to the peak of decline in lung function. This article reviews recent studies on early COPD and the possibility of applying the U.S. Preventive Services Task Force recommendation 2008 and 2015 for early detection of COPD in Korea.
Advisory Committees
;
Disease Progression
;
Early Diagnosis
;
Health Planning Guidelines
;
Korea
;
Lung
;
Prognosis
;
Pulmonary Disease, Chronic Obstructive*
8.A Case of Pulmonary Capillary Hemangiomatosis-Like Lesion Followed for Seven Years.
Chin Kook RHEE ; Nam Yeol YIM ; Soyeon SHIM ; Hui Jung KIM
Tuberculosis and Respiratory Diseases 2011;70(3):242-246
Pulmonary capillary hemangiomatosis (PCH) is a rare disease of unknown etiology that is characterized by nodules composed of infiltrating capillary blood vessels. Herein, we describe a case of a PCH-like lesion that was detected by chest computed tomography. Transthoracic needle aspiration resulted in life-threatening hemorrhage. The patient was followed for seven years. He remained in good health and a follow up image showed little interval change.
Blood Vessels
;
Capillaries
;
Follow-Up Studies
;
Hemorrhage
;
Humans
;
Magnetic Resonance Imaging
;
Needles
;
Rare Diseases
;
Thorax
;
Tomography, X-Ray Computed
9.A first case of high-flow nasal cannula oxygen therapy in patients with pulmonary tumor thrombotic microangiopathy.
Hyonsoo JOO ; Do hyun NA ; Jaeho SEUNG ; Tong Yoon KIM ; Gi June MIN ; Chin Kook RHEE
The Korean Journal of Internal Medicine 2017;32(3):555-558
No abstract available.
Catheters*
;
Humans
;
Oxygen Inhalation Therapy
;
Oxygen*
;
Thrombotic Microangiopathies*
10.A first case of high-flow nasal cannula oxygen therapy in patients with pulmonary tumor thrombotic microangiopathy.
Hyonsoo JOO ; Do hyun NA ; Jaeho SEUNG ; Tong Yoon KIM ; Gi June MIN ; Chin Kook RHEE
The Korean Journal of Internal Medicine 2017;32(3):555-558
No abstract available.
Catheters*
;
Humans
;
Oxygen Inhalation Therapy
;
Oxygen*
;
Thrombotic Microangiopathies*