A case of lymphocytoma cutis, the circumscribed form in 9 year-old girl is reported. This is seldom conclusive without histological examinatien for a wide variety of conditions has to be considered. The circumscribed form usually responds rapidly to radiotherapy, although recurrence is possible and good results from the use of procaine penicillin especially in the disseminated form. In this case, I experienced good results from CO, slush and topical application of 0.25 % fluocortolone 3 times a day without recurrence in 3 months after treatment.
Child ; Female ; Fluocortolone ; Humans ; Penicillin G Procaine ; Pseudolymphoma* ; Radiotherapy ; Recurrence

The authors observed 2 cases of poikilcdermatomyositis who were 16 and l0 years old female. The former visited our dept. due to rashes on the anterior portion of right thigh with 3 months duration. The skin lesion revealed mottled skin pigmentation, telangiectasia, atrophy, and cigarrette paper like wrinklings. On the palpation, hardness and tenderness in the lesion were felt. The latter visited our dept. due to weakness of the right lower extremity for 3years. The skin lesion revealed the same feature as the former but more prominent. Histophthologically, P.V.A. patterns are seen in the both skin lesions. The epidermis shows moderate atrophy of St. malphigi and flattening of reteridges. The dermis is edematous, vascular dilatations, and cellular infiltrations, most of lymphocytes, around the blood vessels. The muscle biopsies for the Quardriceps Femoris sbow Dermatomyositis patterns which the muscle bundles are degenerative changes and many cellular infiltrations, chiefly of lymphocytes, are seen between the muscle bundles. Diagnosis was confirmed by the clinical and histological pictures. These patients were markedly improved by the prednisolone therapy.
Atrophy ; Biopsy ; Blood Vessels ; Dermatomyositis ; Dermis ; Diagnosis ; Dilatation ; Epidermis ; Exanthema ; Female ; Hardness ; Humans ; Lower Extremity ; Lymphocytes ; Palpation ; Prednisolone ; Skin ; Skin Pigmentation ; Telangiectasis ; Thigh

Muchz-Habermann disease is cutaneous disease of unknown etilogy and characterized by a, polymorphous eruption consisting of papulosquamous, bemorrhagic, ulceronecrotic lesion eventually into varioliform scars. It is also classified into parapsoriasis group according to Broq with parapsoriasis en guttata (pityriasis lichenoides chronica), parapsoriasis en plaques, parapsoriasis en lichenoides. The 61-year-old male patient visited to Dermatologic Department of Severance Hospital due to sudden onset of generalized eruption. He presented pea to fingr tip sized erythematous, silvery maculo-papulo-squamous eruptions on trunk, extre- mities and buttock, but didnt complain of any subjective symptoms except markel fatigue. Skin biopsy was done on right forearm and was confirrr.ed to pityriasis lichenoides et varioliformis acuta by histopathologic finding. The lesion was completely controlled by oral tetracycline 2. Ogm per daily for first 4 wecks and reduced dosage l. Ogin per day for second 2 weeks.
Biopsy ; Buttocks ; Cicatrix ; Fatigue ; Forearm ; Humans ; Male ; Middle Aged ; Parapsoriasis ; Peas ; Pityriasis Lichenoides* ; Pityriasis* ; Skin ; Tetracycline

Erythema Annulare Centrifugum is characterized by migratory annular, arcuate or polycyclic erythemas with central clearing. Its etiology is not conclusive but there are many reports about the etiology, i.e." due to dermatophytid"," the drugs",' intemal diseases", or" unknown etiology" etc. A case of Erythema Annulare Centrifugum with "unkown etiology" was reported. The patient revealed slightly elevated, migratory annular erythemas with central clearing on the both posterior portions of thighs. Histopathologically, there was no abnormality in the epidermis. In the dermis, cellular infiltrates sbowing fairly well demarcated perivascular coat-sleeve like arrangement and endothelial prolifera01
Dermis ; Epidermis ; Erythema* ; Humans ; Thigh

The present study was designed to obtain omparative data on in vitro antifungal activities of imidazole derivatives. Minimum inhibitory oncentrations of clotrimazole, miconazole, econazole, ketoconazlole and griseofulvin on 4 strains of Trichophyton mentagrophytes, 3 strains of Trichophyton rubrum, 2 strains of Microsporum canis and ] strain of Sporothriv: schenckii were etermined after 3 week' incubation at room temperature on Sabouraud's dextrose liquid media. In addition, the fungicidal activities of miconazole and econazole were tested against Z'richophyton mentagrophytes and Microsporum canis, using the techniques described by Vanbreuseghern(1967) The results are summarzed as follows: ] In most of the dermatophytes studied, 1 to 10 pg/ml of M1C were detected. Diverse susceptibility pattern was observed among different fungal species, but no or minor variability was noted within the same species. The susceptibility of Z'ri- chophyton rubrum showed at MIC of 0. 01 to 10 pg/ml, T ichophyton mentagro- phyt.es and Mic osporum canis at 0.1 to 10 pg/ml and 0. 1 to 1000 gg/ml respec- tively. The Trichophyton rubrum was the most sensitive. In the susceptibility test of Sporothrix schenckii, the high resistance to clotrimazole and griseofuhin was observed. The fungistatic activities of miconazole, econazole and ketoconazole were observed only at concentrations higher than JpQ pg/ml.
Arthrodermataceae ; Clotrimazole ; Econazole ; Glucose ; Griseofulvin ; Ketoconazole ; Miconazole ; Microsporum ; Sporothrix ; Trichophyton

Diagnosis of dermatophytosis is relatively easy with the typical clinical feature but sometimes we need more studies such as direct microscopy and culture to confirm the diseaee. The direct microscopic test is simple and ra.pid, but the result is often complexing, and the culture needs rnuch experience, skill, and deep knowledge in mycology. In 1959, Taplin et al. devised Dermatophyte Test Medium(DTM) which contains phcnol red as a color indicator for the simplified diagnosis of dermatophytosis. Result can be evaluated by noting the change of the color indicator of the medium. from yellow to red without detailed knowledge of colony morphology. So the non-mycologist can recognize well by color change of the medium. Moreover DTM is superior to Sabouraud medium in eliminating bacterial contamination, allowing a higher recovery rate and early recongnizing, since the color change of the medium begin to appear with the growth of fungus. The cultures were done on DTM and Sabouraud medium in 105 cases of the suspected dermatophytosis. In DTM, dermatophytes were cultured in 53 cases(M. canis 1, T. mentagrophytes 24, T. rubrum 28) and the color changes were observed in all of them. The others were 29 cases of Candida spp. 5 cases of saprophytes, and only one case of bacterial contaminatiion was observed. Compared with DTM, the dermatophytes were cultured in 36 cases and bacterial contamination were 16 csses in Sabouraud medium. The colors of DTM of 53 cases of dermatophytes were changed to red between the second to fourteenth day after culture. In 8 cases of Candida spp. among 29, 3 cases of saprophytes among 5, thc color change of DTM begin to appear after tenth day of culture. So DTM is very useful for the diagnosis of dermatophytosis by unsk;illed personnel under most environmental condition with only redimentary knowledges of colonial morphology to distinguish contaminant fungi and bacteria from dermatophytes.
Arthrodermataceae* ; Bacteria ; Candida ; Diagnosis ; Dronabinol ; Fungi ; Microscopy ; Mycology ; Tinea

Temporal and spatial expression of bmp-2 and bmp-4 was investigated in distraction osteogenesis and fracture healing models in order to delineate their roles in these new hone formation processes. Distraction osteogenesis was performed on the left tihia diaphyses of Sprague-Dawley rats, and was confirmed by serial radiographs and histologicaJ examination. Total RNA was isolated from the distraction gaps and fracture sites sequentially until the postoperative eighth week, and mRNA expression was quantitated hy competitive reverse transcription-polymerase chain reaction(RT-PCR) using specific primers for bmp-2 and bmp-4. In-situ hybridization was performed on the undemineralized tissue section of distraction osteogenesis group. Both bum-2 and bmp-4 mRNA expression increased during distraction osteogenesis and fracture healing. Increase in bmp-2 mRNA expression was more marked and prolonged in distraction osteogenesis compared with fracture healing, whereas bmp-4 mRNA expression was persistently increased in both groups. In-situ hybridization study revealed that hoth bmp-2 and bmp-4 were expressed at eariy osteohlasts producing osteoid, trabeculae-lining osteoblasts and osteocytes of regenerate bone. Enhanced new bone formation in distraction osteogenesis is associated with prolonged and increased expression of BMPs, especially BMP-2. lnspite of their structural similarity, BMP-2 and BMP-4 appear to have their distinct roles in new hone formation.
Bone Morphogenetic Proteins* ; Diaphyses ; Fracture Healing* ; Osteoblasts ; Osteocytes ; Osteogenesis ; Osteogenesis, Distraction* ; Rats, Sprague-Dawley ; RNA ; RNA, Messenger*

Bone is a heterogenous and anisotrophic material exhibiting elastic, viscoelastis and plasticproperties. A considerable amount of information is now available regarding biomechanical properties and mechanisms of fractures of mature long bones, but less is known about the properties of the growing bones. In order to assess the biomechanical properties under tension, rabbits growing bones were loaded with Instron Modal 1,000 until fracture occurred. Two hundred tibiae of 100 New Zealand white immature rabbits were divided into 6 experimental groups according to maturity and size. Group I-R(40 right tibiae of 1-month old rabbits), Group I-L (40 left tibiae of 1-month old rabbits), Group II-R(20 right tibiae of 3-month old rabbits), Group II-L (20 left tibiae of 3-month old rabbits), Group III-R(40 rigth tibiae of 5-month old rabbits), and Group III-L(40 left tibiae of 5-month old rabbits). The following results were obtained. 1. Fracture type was transverse.or nearly transverse in 170 out of the total 200 tibiae(85%).
Absorption ; Elastic Modulus ; New Zealand ; Rabbits ; Tensile Strength ; Tibia

BACKGROUND: Intraoperative neurophysiologic monitoring(INM) is well known to be useful method to reduce intraoperative complications during tumor surgery in cerebellopontine angle(CPA). We investigated the changes of INM during the surgery. It might be helpful to keep one's eyes on which monitoring modalities are reluctant to change during the operation. METHODS: We included 49 subjects who had undergone CPA tumor surgery under INM. Their pathology was as follows; vestibular schwannoma in 37, other cranial nerve schwannoma in 3, meningioma in 5 , cyst in 2. The modalities of monitoring were short latency auditory evoked potentials(AEP), somatosensory evoked potentials(SEP) , facial and trigeminal nerve EMG(EMG). Stimulation of SEP was on left or right median, posterior tibial nerves. We studied the frequency of abnormal INM changes and the factors affecting it. RESULTS: The subjects who had abnormal changes in at least one monitoring modality were 19(38.8.%). AEP changes were in 6.1%, SEP in 12.2% and EMG in 24.5%. The AEP monitoring had no potentials from II through V wave in 28 subjects(57.1%). SEP monitoring had improvement in 2 subjects and aggravation in 6, especially involved in median nerve SEP. Tonic EMG activities were observed in 3 facial muscles of 3 subjects, 2 of 4, 1 of 5. Regarding the pathology of tumor, meningioma had much more changed INM than vestibular schwannoma. The volume of tumor was bigger in abnormal INM group than normal group although it is not statistically significant. Also abnormal SEP and EMG group had bigger mass than normal group. CONCLUSIONS: INM has frequent electrophysiologic changes during tumor surgery in CPA. Especially EMG can be changed the most frequently. The larger tumor are, the more frequently abnormal changes in INM of CPA tumor surgery are.
Cerebellopontine Angle* ; Cranial Nerves ; Facial Muscles ; Intraoperative Complications ; Median Nerve ; Meningioma ; Monitoring, Intraoperative ; Neurilemmoma ; Neuroma, Acoustic ; Pathology ; Tibial Nerve ; Trigeminal Nerve

We reviewed clinical manifestation of 12 patients from three Korean families. They showed mild to moderate bone fragility, and suggested an autosomal dominant inheritance pattern. Significant intrafamilial phenotype variability was obvious. Clinical, radiological, and histopathologic characteristics that distinguished this subtype from others include ossification of interosseous membrane of the forearm with radial head dislocation, hyperplastic callus formation, no evidence of type I collagenopathy and an abnormal histopathologic pattern. Severity of the interosseous membrane ossification was correlated with increasing age (p<0.01) and the radial head dislocation was thought to be a developmental problem rather than a congenital problem. Four children who had bisphosphonate treatment showed improved bone mineral density, radiological changes, and biochemical responses. Osteogenesis imperfecta type V was a distinctive subtype of osteogenesis imperfecta, which caused mild to moderate disability clinically.
Range of Motion, Articular ; Pedigree ; Osteogenesis Imperfecta/genetics/*pathology/physiopathology ; Middle Aged ; Male ; Infant ; Humans ; Fractures, Bone/radiography ; Female ; Family Health ; Dislocations/radiography ; Child, Preschool ; Child ; Bone and Bones/abnormalities/*radiography ; Aged ; Adult