A single dose of Tetramisole, 2.5 mg/kg body weight, was given to the infected cases of intestinal parasites. The number of cases were: Ascaris lumbriocides 96, hookworm 16, Trichostrongylus orientalis 10, Trichocephalus trichiurus 114 and Clonorchis sinensis 19. No dietary restriction before and after the administration of Tetramisole was required. In Ascaris infection the egg negative conversion rate and the egg reduction rate were 92.7 per cent and 99.5 per cent, respectively. In Trichostrongylus orientalis infections, 9 out of 10 cases were resulted egg negative after the single dose of Tetramisole, and hookworm, 12 out of 16 administered showed egg negative. However, there were no appreciable effectiveness to the cases of Trichocephalus trichiurus and Clonorchis sinensis. Mild and transient side effects were noted in 75 cases (54.5%) out of 140 cases. The main symptoms were dizziness (25.5%), anorexia (25.5%), abdominal pain (18.6%), diarrhea (16.6%), headache (15.2%), nausea (14.4%) and fever (11.0%). From the above results, it is anticipated that Tetramisole is an effective anthelminthic for elimination of Ascaris, Trichostrongylus and hookworm.
parasitology-helminth-trematoda-nematoda ; Ascaris lumbricoides ; hookworm ; Trichostrongylus orientalis ; Trichocephalus trichiurus ; Clonorchis sinensis ; chemotherapy-Tetramisole ; 2,3,5,6,- tetrahydro 6- phenyl-imidazole (2,1-b) thiazole hydrochloride ; dizziness ; anorexia ; abdominal pain ; diarrhea ; headache ; nausea ; fever ; Tetramisole

A complete but abnormal form of Taenia worm was obtained from an 18-year-old male student in Cheju Island, Korea, which has been known as a heavy endemic area of Taenia saginata and few of T. solium. There was an apical hookless eminence in the scolex, longitudinal white line along the middle portion of entire strobila, double genital pores and several lateral buddings from the strobila. It was considered an abnormal form of Taenia species, probably T. saginata.
parasitology-helminth-cestoda-Taenia saginata ; Taenia sp. ; case report

Utrerine myoma is one of the most commonly encountered gynecologic problem in daily ultrasonographic practice,and is one of the few conditions with which specific histologic diagnosis is possible by ultrasonography in selected patients as well. We recently analysed ultrasonograms of 132 cases of uterine myoma and 31 cases thatshowed similar ultrasonographic findings of myoma, histopathologically verified in both cases. The results were as follows. 1. The diagnostic accuracy by ultrasonography was 93%. 2. The most common ultrasonographic findings of uterine myoma were nodular enlargement of uterus and irregular internal echo texture changes. 3. It was not possible to differentiate the various kinds of secondary degeneration by ultrasonography, except for calcification and cystic change. 4. It was usually unable to differentiate solitary from multiple myoma, and subserosal,interstitial and submucosal types from each other by ultrasonographic findings alone, except for the usual cases of exophytically growing subserosal mass. 5. The most frequent disease that is hard to differentiate from small uterine myoma was adenomyosis, and therefore it is considered necessary to include the adenomyosis in differential diagnosis in the diagnosis of myoma causing moderatelly enlarged uterus.
Adenomyosis ; Diagnosis ; Diagnosis, Differential ; Humans ; Leiomyoma ; Myoma ; Ultrasonography ; Uterus

Fifty-nine histologically proven cases of carcinoma of the larynx and hypopharynx were examined with CT forthe staging before surgery or radiation therapy and the findings of primary disease and neck metastasis wereanalyzed. Local extension of the tumor can be easily evaluated with CT and findings of lymph node metastasis ofneck were seen in 33 cases(79%) of all. Among cases of neck metastasis, peripheral contrast enhancement of thelymph nodes were demonstarated in 26 cases (79%).
Hypopharynx ; Larynx ; Lymph Nodes ; Neck ; Neoplasm Metastasis

PURPOSE: The purpose of this study was to evaluate the usefulness of CT-guided percutaneous needle aspiration(PCNA) of paraaortic and pelvic lymph nodes in patients with uterine cervical carcinoma. MATERIALS AND METHODS: CT-guided PCNA was performed in 18 patients with treated cervical carcinoma. initial clinical stages were CIS in one, lb in three, lib in ten, and IIIb in four cases. We used 20 gauge Westcott needles for aspiration. Mean depth from skin to lymph nodes was 10.0cm in paraaortic group (n=13) and was 7.9cm in pelvic group (n=5). The size of lymph nodes ranged 1.0-3.0cm (mean :1.8) and 1.5-5.0cm (mean :2.6cm), respectively. RESULTS: All cases with paraaortic lymph node enlargement were proved to be metastatic lymphadenopathy. In five cases with pelvic lymph node enlargement, three were proved to be malignancy and two were negative. Among 16 cases with metastatic lymphadenopathy, eight patients were treated with chemotherapy, five with radiation therapy, and three with chemotherapy and radiotherapy. In two cases with negative results lymph nodes were disappeared or unchanged on follow up CT scans. No complications were encountered during CT-guided PCNA procedure. CONCLUSION: CT-guided PCNA of paraaortic and pelvic lymph nodes is a useful method in determining metastasis from cervical carcinoma and in planning further treatment.
Biopsy, Fine-Needle* ; Drug Therapy ; Follow-Up Studies ; Humans ; Lymph Nodes* ; Lymphatic Diseases ; Needles ; Neoplasm Metastasis ; Proliferating Cell Nuclear Antigen ; Radiotherapy ; Skin ; Tomography, X-Ray Computed

BACKGROUND: Substrates play an important role in the effectiveness of the indirect immunofluro-rescence test. The monkey eaophagus has been known to be a more reliable and reproducible substrate than any other animal substrates for detecting pemphigus vulgaris autoantibodies, but it is quite difficult to get the monkey esophagus in Korea, therefore, we tried to find other substrates which could be substituted for it. OBJECTIVE: We studied to select the substrate which can be the most sensitive, to compare the immunofluorescent sensitivity of various animal substrates and fores,cins for detection of pemphigus autoantibodies, and finally to evaluate the effectiveness of cultured hunan keratinocytes as a substrate for indirect immunofluorescerice. METHOD: With foreskin, guinea pigs, cats, rats, dogs, rabbits and cultured human keratinocytes as substrates, an indirect imrnunofluorescence test was performed to detect pemphigus vulgaris autoantibodies in seven sera from the active patients before treatment and diluted serially from 1:10 to 1:1280 RESULT: We could detect pernphigus autoantibodies in all animal subtrates used in this study except rats and obtain good immunofluorescent results with foreskin, guinea pigs, and cultured human keratinocytes. The results were moderate with dogs, cats, rabbits, and poor with rats. CONCLUSION: We confirm thut cultured human keratinocytes can be a good effective substrate. According to effectiveness, subtrates can be divided into three groups. Foreskin, guinea pigs, and cultured human keratinocytes are included in the good effective substrate group, dogs, cats, and rabbits in the modeate group and rats in the poor substrate group, but we can not find any superiority of substrates within each groups.
Animals ; Autoantibodies* ; Cats ; Dogs ; Esophagus ; Fluorescent Antibody Technique, Indirect* ; Foreskin ; Guinea Pigs ; Haplorhini ; Humans ; Keratinocytes ; Korea ; Pemphigus* ; Rabbits ; Rats

Bone or bone substitute has been widely used for the reconstruction of bony defect developed by trauma, infecton, cyst, tumor, congenital abnormality, etc. Owing to its variety in quality and quantity, the use of alloplasts is increased rapidly. Among the various graft materials, HA has been studied and applied in clinic most exensively. When HA applied to bony defect, it is considered to help the bone healing by osteoconduction but tends to be encapsulated with fibrous tissue and floated in the applied area by the lack of consolidation. Bioglass is considered as a subsitute which can cover such weak point of HA. Bone defect were artificially prepared in the calvaria of the rats followed by grafts of HA and bioglass into defects. Sequential sacrifice was peformed at the 3rd, 7th, 14th and 28th day of experiment. The staining of the obtained specimen was performed with H&E, MT, immunohistochemical stain and then histological examinaions were carried out under the light and scanning electron microscope. 1. In the features of H&E stain, infiltration of chronic inflammatory cell were present in all group at the 3rd and 7th day of experiment with decrease at the 14th day in bioglass group. The infiltration of inflammatory cells was more active in control and HA group whereas the formation of granulation tissue was more active in bioglass group was larger and more irregular than in HA group. 2. The features of MT stain showed new bone formation from the 7th day in all groups and the evidence of advanced calcification was observed at the 28th day. 3. In the features of immunohistochemical stain, bioglass group showed more PCNA positive response in the osteoblasts at the site of new bone formation and the lower activity of undifferentiated mesenchymal cells than HA group. 4. In scanning electron microscopic features, fibrous tissue formation and osteoid attached to HA was observed in the HA group after the 7th day. In bioglass group, osteoid formation was observed between the absorbed bioglass. Generally in HA group, bone formation progressed with characteristic of the fibrous and osteoid tissue mainly attached to the surface and the high activity of undifferented mesenchymal cells was seen at the graft site. In bioglass group, osteoid tissue formation was seen between the irregulary absorbed bioglass and the increased PCNA positive response was observed in the osteoblast at the new bone formation site.
Animals ; Bone Regeneration ; Bone Substitutes ; Congenital Abnormalities ; Durapatite* ; Granulation Tissue ; Osteoblasts ; Osteogenesis ; Proliferating Cell Nuclear Antigen ; Rats* ; Skull ; Transplants

We retrospectively analyzed the clinical and CT manifestation of 12 patients with nonlymphomatous renal metastases from eight different sites. Primary sites were lung(2), liver (2), stomach(2), uterine cervix (2), pancreas(1), rectum(1), penis (1), and unknown primary site(1). In all patients, clinical symptoms and laboratory findings were nonspecific. Major CT findings of renal metastases were multiple, small, hypodense lesions concomitant with multiple organ involvement. Although there are few differential points between renal cell carcinoma and metastasis, the single most important differential point was the presence of mass lesion on location other than kidney and in such case, the lesion on kidney proved to be metastasis usually. In cases with remission of primary malignancy, biopsy of new renal lesion seemed to be indispensable.
Biopsy ; Carcinoma, Renal Cell ; Cervix Uteri ; Female ; Humans ; Kidney ; Liver ; Male ; Neoplasm Metastasis* ; Penis ; Retrospective Studies

PURPOSE: We evaluated the effectiveness of balloon dilatation and bougienage of post operative anastomotic stricture of upper G-I tract. MATERIALS AND METHODS: We performed 22 balloon dilatation and 24 Bougienage in 40 patients of post operative anastomotic stricture. The causes of operation were esophageal cancer(n=20), stomach cancer(n=16), laryngeal cancer(n=2), chemical(n=2) strictures. RESULTS: Successful dilatations of the anastomotic site stricture were achieved during the procedure in 38 patients(95%). There was one case of esophageal perforation as a complication. CONCLUSION: Esophageal balloon dilatation and Bougienage are safe and effective method for post operative anastomotic site stricture of upper G-I tract.
Constriction, Pathologic* ; Dilatation* ; Esophageal Perforation ; Humans ; Stomach

The combination of the various diagnostic methods of palpable breast mass has improved the diagnosticaccuracy. From Sep.1983 to Aug. 1985 pathologically proven 85 patients with palpable breast masses examined withX-ray mammography, ultrasonography, penumomammography and aspiration cytology at Korea Cancer Center Hospital wereanalyzed. The diagnostic accuracies of each methods were 77.6% of mammogram, 74.1% of ultrasonomgram, 90.5% ofpenumommaogram and 92.4% of aspiration cytology. Pneumommamograms was accomplished without difficulty orcomplication and depicted more clearly delineated mass with various pathognomonic findings; air-ductal pattern infibroadenoma(90.4%) and cystosarcoma phylloides(100%), air-halo in fibrocystic disease(14.2%), fibroadenoma(100%),cystosarcoma phylloides (100%), air-cystogram in cystic type of fibrocystic disease(100%) and vaculoar pattern orirregular air collection without retained peripheral gas in carcinoma.
Breast ; Humans ; Korea ; Mammography ; Ultrasonography