1.Clinico-epidemiological profile, including body mass index of Malaysian children with psoriasis
Siew Eng Choon ; Chin Fang Ngim ; Premaa Supramaniam ; Kwee Eng Tey ; Nalini Nanu Madhavan
The Medical Journal of Malaysia 2016;71(4):171-176
background: Limited information exists regarding paediatric
psoriasis and its association with body mass index (bMI) in
Asia.
Objectives: to determine the clinico-epidemiological profile
and to compare the bMI of children with and without
psoriasis.
Methods: A case-control study of 92 children with psoriasis
versus 59 with atopic eczema and 56 with non-inflammatory
skin conditions.
results: Psoriasis was more common in Malay and Indian
children when compared to Chinese with odds ratios (Or) of
4.30 (95% CI, 1.85-9.99) and 3.00 (95% CI, 1.02-8.81)
respectively. Prevalence of psoriasis was similar between
Malay and Indian children (Or 1.43, 95% CI, 0.63-3.25).
Male:female ratio was 1:1.09. the mean onset age of
psoriasis was 7.9 years. Median onset age was earlier in
males (6.5 years versus 9.0 years in females, p=0.05).
Plaque psoriasis was the most common phenotype (89.1%)
and 94.5% had scalp lesions. Arthritis was seen in 4.3%.
Odds of excess adiposity, defined as bMI ≥85th percentile,
was higher in children with psoriasis versus noninflammatory
controls (Or 2.35, 95% CI 0.99-5.56, p= 0.052).
No increased risk of adiposity was noted between children
with psoriasis and eczema (Or 1.14, 95% CI 0.5-2.62,
p=0.753). More children with psoriasis (17.4%) and eczema
(20.3%) were underweight (bMI <5th percentile) compared to
non-inflammatory controls (10.7%).
Conclusion: Malays and Indians are three to four times more
likely than Chinese to have psoriasis in multi-ethnic
Malaysia. Plaque psoriasis is the most common phenotype.
Odds of excess adiposity is about two times higher in
children with psoriasis compared to non-inflammatory
controls although this observation just missed conventional
statistical significance.
Psoriasis
2.Skill validation study on sentinel lymph node biopsy in breast cancer and the challenges of false-negative, in-transit and micrometastatic nodes
Chen Siew Ng ; Sarojah Arulanantham ; Joon Joon Khoo ; Subathra Sabaratnam ; Yeong Fong Lee ; Chin Fang Ngim
The Medical Journal of Malaysia 2016;71(5):275-281
3.A web-based educational intervention module to improve knowledge and attitudes towards thalassaemia prevention in Malaysian young adults
Chin Fang Ngim ; Hishamshah Ibrahim ; Nisah Abdullah ; Nai Ming Lai ; Ronnie Kian Meng Tan ; Chen Siew Ng ; Amutha Ramadas
The Medical Journal of Malaysia 2019;74(3):219-225
Background: Thalassaemia is a public health burden in
Malaysia and its prevention faces many challenges. In this
study, we aimed to assess the effectiveness of a web-based
educational module in improving knowledge and attitudes
about thalassaemia prevention amongst Malaysian young
adults.
Methods: We designed an interactive web-based
educational module in the Malay language wherein videos
were combined with text and pictorial visual cues.
Malaysians aged 18-40 years old who underwent the module
had their knowledge and attitudes assessed at baseline,
post-intervention and at 6-month follow-up using a selfadministered validated questionnaire.
Results: Sixty-five participants: 47 Malays (72.3%), 15
Chinese (23.1%), three Indians (4.6%) underwent the module.
Questionnaires were completed at baseline (n=65), postintervention (n=65) and at 6-month follow-up (n=60). Out of a
total knowledge score of 21, significant changes were
recorded across three time-points- median scores were 12 at
pre-intervention, 19 at post-intervention and 16 at 6-month
follow-up (p<0.001). Post-hoc testing comparing preintervention and 6-month follow-up scores showed
significant retention of knowledge (p<0.001). Compared to
baseline, attitudes at 6-month follow-up showed an
increased acceptance for “marriage avoidance between
carriers” (pre-intervention 20%, 6-month follow-up 48.3%,
p<0.001) and “prenatal diagnosis” (pre-intervention 73.8%,
6-month follow-up 86.2%, p=0.008). Acceptance for selective
termination however, remained low without significant
change (pre-intervention 6.2%, 6-month follow-up 16.7%,
p=0.109).
Conclusion: A web-based educational module appears
effective in improving knowledge and attitudes towards
thalassaemia prevention and its incorporation in
thalassaemia prevention programs is potentially useful in
Malaysia and countries with a high internet penetration rate.