1.Colorectal Cancer Screening Using Immunochemical Fecal Occult Blood Test
Mun Chieng Tan ; Ooi Chuan Ng ; Ray Yee Paul Yap ; Yan Pan ; Jin Yu Chieng
Malaysian Journal of Public Health Medicine 2017;17(1):33-37
Fecal occult blood test (FOBT) screening has been shown to decrease the incidence and mortality of colorectal cancer
(CRC). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the
immunochemical fecal occult blood test (i-FOBT) in diagnosing CRC were assessed among the patients in a tertiary
referral hospital in Malaysia. A total sample of 814 patients aged 16 to 85 years old who performed i-FOBT and
endoscopic screenings was obtained. The patients were recruited for a retrospective investigation. Sensitivity,
specificity, PPV, and NPV were derived for the CRC screenees. Out of the 814 patients screened using i-FOBT, half of
them were above 59 years old (49.6%), and 36% had positive i-FOBT. Gender distribution was almost equal, where 53.4%
of the patients were female, and 46.6% were male. Majority of the patients were Malays (56.6%), followed by Chinese
(24.0%), Indians (16.5%), and others (2.9%). Among the 71 patients referred for colonoscopy, 57.7% and 42.3%
corresponded to positive and negative i-FOBT cases, respectively. Polyps were found to be most common among the
patients (25.6%), 7.0% were found positive for invasive CRC, and 35.2% had normal colonoscopic findings. There was a
significant association between colonoscopic finding and positive i-FOBT (p=0.001). The sensitivity, specificity, PPV, and
NPV for CRC detection were 66.7%, 43.0%, 9.8%, and 93.3%, respectively. The results indicate that i-FOBT is a useful tool
in the detection of abnormalities in the lower gastrointestinal tract and therefore serves as a cornerstone for potential
large-scale screening programmes.
2.Prevalence of Helicobacter Pylori Infection among Patients Attending Gastroenterology Endoscopy Unit at Serdang Hospital
Chieng Jin Yu ; Pan Yan ; Loong Yik Yee
Malaysian Journal of Medicine and Health Sciences 2015;11(1):11-17
To study the prevalence of Helicobacter Pylori (H. pylori) infection, according to ethnicity, gender and
endoscopic findings among the patients underwent the oesophago-gastro-duodenoscopes (OGDS) at
gastroenterology endoscopy unit, Hospital Serdang, Selangor, Malaysia. The database of all whom
underwent OGDS at the gastroenterology endoscopy unit, Hospital Serdang from 1st August 2010
to 31st July 2012 was collected and assessed, retrospectively. A total of 924 patients who underwent
OGDS were analyzed for the H. pylori infection by using Campylobacter-like organism (CLO) test. 130
(14.07%) tested positive, and their data were further studied according to gender, ethnicity, age group,
initial indication for OGDS and endoscopic finding. The prevalence rate among males was 15.15%
(70/462), while it was 12.99% (60/462) among females. In terms of ethnics, H. pylori infection was
commonly found among Indian and Chinese with prevalence rate of 25.13% (50/199) and 17.41%
(51/293) respectively. These figures are significantly higher than the 6.01% (25/416) for Malays. The
age group (31-50 years old) had the highest prevalence rate of H. Pylori infection, which is of 18.55%
(41/221). No significant difference was observed among initial indications for OGDS. Erosions were the
commonest finding in H. pylori positive group with rate of 51.54% (67/130). However, erosions were
not uncommon in H. pylori negative group as well with the rate of 48.61% (386/794). H. pylori infection
rate among Malaysians was generally low, with the highest rate in Indians, followed by Chinese and
relatively low in Malays. No significant difference between the prevalence rate of H. pylori infection
in male and that in female was found. Erosions were equally common in either H. pylori positive or H.
pylori negative group.
.
Helicobacter pylori
3.Detection rate of colonic polyp among patients who had undergone colonoscopy at gastroenterology unit of Serdang Hospital, Malaysia
Tan Yi Jun ; Wedy Tan ; Chieng Jin Yu
The Medical Journal of Malaysia 2019;74(1):20-24
The aim of this study was to evaluate the
demography, and to determine the detection rate of polyps,
and detection rate of adenoma at a Malaysian tertiary
hospital.
4.Assessment of the level of knowledge of colorectal cancer among public at outpatient clinics in Serdang Hospital: a survey based study
Pan YAN ; Chieng Jin YU ; Ahmad Amirul Hafiz Haris ; Ang Shih YUAN
The Medical Journal of Malaysia 2017;72(6):338-344
Objectives: Colorectal cancer (CRC) is one of the mostcommon gastrointestinal cancers in the world. In the AsiaPacificregion, it is the fastest emerging gastrointestinalcancer. Level of awareness on CRC warning signs and riskfactors in the rural population of Malaysia is reported of verylow. The aim of this study was to assess the level ofknowledge of CRC among the public at medical outpatientclinics in Serdang Hospital. The association between sociodemographicfactors with level of knowledge among therespondents was further studied.Study design: A study was conducted among the non-CRCpatients’ relatives accompanying their relatives to themedical outpatient clinics in Serdang Hospital from 1st Aprilto 31st August 2016. The study was carried out with clustersampling method.Methods: The respondents were assessed using validatedand modified Cancer Awareness Measures (CAM)questionnaire consists of three parts which are knowledgeon warning signs, knowledge on risk factors and sociodemographicfactors. All data were analysed using IBMSPSS Statistics 21.0.Results: Altogether 308 subjects completed thequestionnaires. It was shown high percentage of goodknowledge for warning signs and risk factors of CRC amongthe respondents. A significant association between agegroups and level of income with level of knowledge onwarning signs was observed.Conclusions: The level of knowledge of CRC among thegeneral public in Serdang Hospital was sufficient. Therespondents with higher income or younger age had higherlevel of knowledge regarding CRC.
5.Aetiologies of Liver Cirrhosis among Adult Patients Attending A Hepatology Clinic at Selangor, Malaysia
Chieng Jin Yu ; Pan Yan ; Liew Chiat Fong ; Mazawawi Muhammad ; Syed Anas Tamamulqomar Said Abu Hassan
International Journal of Public Health Research 2022;12(no.1):1493-1501
Introduction :
Liver cirrhosis is an important cause of morbidity and mortality.
Methods:
Our study aimed to describe the clinical pattern of cirrhosis and its associated factors among adult patients attending Hepatology Clinic, Serdang Hospital, Malaysia from 1st January 2010 to 30th June 2017. Aetiology was further determined by history, biochemistry and/or histology. The severity of the cirrhosis, together with the presence of complications and incidence of hepatocellular carcinoma were documented.
Results:
A total of 357 adult patients were diagnosed with cirrhosis including 199 male patients (55.7%) and 158 female patients (44.3%), with a mean age of 54-year-old (range: 28-84 year-old). The causes of cirrhosis were chronic hepatitis B (N=145, 40.6%), chronic hepatitis C (N= 67, 18.8%), cryptogenic liver disorder (N= 63, 17.6%), alcohol (N=42, 11.8%), non-alcoholic fatty liver disease (N=25, 7.0%), and others (N=15, 4.2%). Chronic hepatitis B was the predominant aetiology among Chinese whereas alcohol was the main aetiology among Indians, and Hepatitis C cirrhosis was highest among Malays. Majority of the patients had compensated cirrhosis with Child-Pugh A (N=221, 61.9%) at the time of diagnosis. 80.4% (N=287) of the cirrhotic patients had performed at least one endoscopy surveillance, with 28.6% (82/287) of them had endoscopic evidence of portal hypertension. 32.2% of patients had at least one hospitalization due to complication of cirrhosis. 41 patients (11.5%) had concurrent hepatocellular carcinoma during the follow up.
Conclusions
Despite universal hepatitis B vaccination, Hepatitis B viral infection remains the most common cause of cirrhosis among patients attending Hepatology Clinic, Serdang Hospital.