〔Abstract〕 The paper elaborates the definition of Biobank and the significance of constructing Biobank standardized system, through comparison of Biobank development process and experiences between China and abroad, it analyzes the existing problems and reasons of Biobank standardized system construction in China, puts forward corresponding advices.

We searched and retrieved literature on the topic of medical image processing published on SCI journals in the past 10 years. We then imported the retrieved literature into TDA for data cleanup before data analysis and pro cessing by EXCLE and UCINET to generate tables and figures that could indicate disciplinary correlation and research hotspots from the perspective of bibliometrics. The results indicated that people in Europe and USA were leading researchers on medical image processing with close international cooperation. Many disciplines contributed to the fast development of medical image processing with intense interdisciplinary researches. The papers that we found show recent research hotspots of the algorithm, system, model, image and segmentation in the field of medical image processing. Cluster analysis on key words of high frequency demonstrated complicated clustering relationship.
Algorithms ; Bibliometrics ; Cluster Analysis ; Diagnostic Imaging ; trends ; Humans ; Image Processing, Computer-Assisted ; trends ; International Cooperation

Technology readiness level (TRL) refers the general maturity level of a single technology or technical systems (including technology,component or subsystem) during the process of development.Base on the original TRL proposed by NASA,with reference to medical device TRL modified by US Department of Defense and NATO,this study modified TRL definition and description for advanced medical devices with consideration of R&D,review and approval characteristics of advanced medical devices in China.

ObjectiveTo assess the satisfaction of general practical students' perception with the two modes of histologic laboratory instruction,and obtain the advantages and disadvantages of each mode.MethodsWeb-based database was established and in the questionnaires were delivered to the general practical students ( n=193 ).Results75％ of students agreed that the case study component of the webbased laboratory instruction was arranged in order.82％ of students identified with the detailed word explanation attached to every image presented.ConclusionStudents support the progression of web-based histologic laboratory instruction,but it is difficult to replace traditional microscope with web-based database in histologic laboratory instruction.

Through the analysis of the current status and problems of innovative medical devices evaluation, tnis paper discussed the strategies of evaluation, and ultimately raises the frame of evaluation, so as to provide reference for scientific evaluation of medical devices in China.
China ; Equipment and Supplies ; standards ; Evaluation Studies as Topic

Sixteen compounds including daphnoretin (1), isofraxidin (2), scopoletin (3), kaempferol (4), quercetin (5), guaijaverin (6), astragalin (7), quercetin-3-O-β-D-glucopyranoside (8), naringenin-7-O-β-D-glucopyranoside (9), 5-O-methylapi- genin-7-O-β-D-glucopyranoside (10), methyl gallate (11), prionitiside A (12), (2S)-2,3-dihydroxypropyl-1,6,8-trihydroxy-3- methyl-9,10- dioxoanthracene-2-carboxylate (13), 3,3'-di-O-methyl ellagic acid (14), 3'-O-methyl-3,4-O,O-metheneellagic acid-4'-O-β-D- glucopyranoside (15) and 3,4-methylenedioxy-3'-O-methylellagic acid (16), were isolated from the 70% acetone extract of Euphorbia dracunculoides Lam. Among them, compounds 1-3, 6-9, 11, and 14 were isolated from E. dracunculoides for the first time, and compounds 10, 12, 13, 15, and 16 were firstly obtained from the genus Euphorbia. Their structures were elucidated by spectroscopic analysis, including 1H-NMR, 13C-NMR, and ESI-MS.
Drugs, Chinese Herbal ; chemistry ; isolation & purification ; Euphorbia ; chemistry ; Molecular Structure ; Plant Leaves ; chemistry ; Plant Stems ; chemistry ; Spectrometry, Mass, Electrospray Ionization

Objective To review the "Twelfth Five-Year Plan" and provide the outlook of the innovation system of Chinese medical science and technology in "Thirteenth Five-Year Plan".Methods This article mainly investigates the layout and results regarding innovation system of Chinese medical science and technology in "Twelfth Five-Year Plan" and the "Thirteenth Five-Year Plan" respectively.Results The layout of the "Twelfth Five-Year Plan" in medical technology field has provide guarantees for promoting the construction of healthy China.Meanwhile,Chinese innovation abilities in this field has been improved.Additionally,technology and equipment in China have been upgraded.However,there are still some problems,such as the lack of original research innovation capacity and urgency in the task of product quality upgrading etc.Since the "Thirteenth Five-Year Plan" is considered as the decisive stage in the process of building Chinese well-off society,it is necessary to increase the layout and investment in terms of innovation system of Chinese medical science and technology.Conclusions On the basis of "Twelfth Five-Year Plan","Thirteenth Five-Year Plan" will grasp the direction of technological progress of medical industry,and continue to promote innovation as well as provide support for improving the abilities of research and development,which could provide an inexhaustible driving force of medical technique innovation for China.

The paper reviewed the development history, current application and technical features of 3D ultrasound and 3D breast ultrasound. 3D ultrasound is used in breast screening methods. Special 3D breast ultrasound equipment can enhance breast characteristics, corresponding the breast characteristics to carry out technological innovation and improvement, provide more accurate and convenient way to inspect breast.
Breast Neoplasms ; diagnostic imaging ; Female ; Humans ; Imaging, Three-Dimensional ; Ultrasonography, Mammary ; methods

Objective: To research the competitive situation of technical research on the field of surgical robot and analyze direction of technical development of this field.Methods: The data of Derment Innovation(DI)platform were applied,and the patent analysis method was adopted to combined with visual tool to analyze patents of surgical robot field from various aspects such as the number of patent application,technology life cycle,the trend of regional development,competitor and trend of technical development.Results: There were 1491 patent applications in the globally surgical robot field,and technological fields were concentrated in endoscope,surgically mechanical arm,electronic data processing system,intervention,implantation of related equipment,regulatory system,image processing and transmission,stress and torque,etc.United States and China not only were the major technical birthplace but also were the important target markets in surgical robot field.And enterprises were the main research and development institutions in abroad,while colleges and universities were main institutions in China.Conclusion: The field of surgical robotics is in a fast developing period,and endoscope and surgically mechanical arm are the focusing technical development direction and they obtain most attentions.

The key factor responsible for the slowness of registration of medical devices in China is clinical trial. The clinical trial in European and U.S. is taken as an example to analyze the problems in clinical trials in China. Some suggestions are proposed to solve the problem.
China ; Clinical Trials as Topic ; Device Approval ; Research Design