1.Neuroendocrine Differentiation in Adrenal Cortical Tumor of Chidhood: A case report.
Sang Yong SONG ; Seung Sook LEE ; Na Hye MYUNG ; Je G CHI
Korean Journal of Pathology 1993;27(2):175-180
Although neuroendocrine differentiation is a characteristic feature of tumors of the adrenal medulla, cortical tumors may also rarely be differentiated into medullary element. Recently we experienced such a case of adrenal cortical tumor having features of both cortical and medullary tumor. The patient was an 11-year-old girl who was incidentally found to have a left adrenal mass. Laboratory results showed elevated serum cortisol, aldosterone, renin, and epinephrine with high excretion of urinary metanephrine. Urine vanillyl mandelic acid and 17-ketosteroid remained within normal limits. Histologic featuresof a 6 cm round yellowish tumor were ambiguous to decide the orgin of this neoplasm. Cortical element predominated in the tumor with minor areas of pheochromocytomatous feature. Immunohistochemically, the tumor cells were positive for vimentin, neuron specific enolase, and epithelial membrane antigen. Ultrastructural examination revealed scattered membrane bound dense core granules in the tumor cells of medullary differentiation, measuring 150~500 nm in average diameter. Cortical tumor element showed corresponding ultrastructural features. These results indicate that this is a case of adrenal cortical tumor with features of neuroendocrine differentiation.
Child
;
Male
;
Female
;
Humans
2.Effects of Diuretics on Serum and Urinary Electrolytes in Patients with Hypertension.
Ki Cheol KIM ; Seok Pil KIM ; Young Min LEE ; Chi Myung SONG ; Sang Ki YANG ; Chang Sup SONG
Korean Circulation Journal 1986;16(2):263-270
In order to investigate electrolyte changes in serum and urine diuretic therapy, we studied 98 patients with hypertension not optimally controlled by previous treatment. After we divied the patients into three gorups in randomized trial, group A were given Amiloride 10mg/day, group B were given Dihydrochlorothiazide 50mg/day, group C were given Amiloride 5mg/day combined with Dihydrochlorothiazide 25mg/day for 7 days. Blood pressure and electrolyte changes in serum and urine after diuretic theraphy for 7 days were as follows. 1) Serum sodium concentrations were not significantly changed in all three groups(P>0.05). 2) Serum potassium concentrations were increased in group A and C (P<0.05), but there were no significant changes in group B(P<0.05). 3) Urinary sodium exceretions were increased in all three groups(P<0.05). 4) Urinary potassium excretion were decreased in group A and C (P<0.05), but there were increased in group B (P<0.05). 5) Blood pressure were decreased in all three groups(P<0.05).
Amiloride
;
Blood Pressure
;
Diuretics*
;
Electrolytes*
;
Humans
;
Hydrochlorothiazide
;
Hypertension*
;
Potassium
;
Sodium
3.Giant Fusiform Aneurysm by Circumferential Wrapping with Sutures-Reinforcement.
Young Il HA ; Kwan Young SONG ; Sung Soo BAN ; Chi Sung AHN ; Myung Hun CHUNG ; Dong Soo KANG
Journal of Korean Neurosurgical Society 1999;28(10):1505-1511
Adirect intracranial operative approach with clipping the neck of the aneurysm is generally considered to be the ideal treatment for the intracranial arterial aneurysms. Several strategies exist for treating unclippable aneurysms. Intravascular techniques, proximal occlusion of the parent artery or trapping of the aneurysm, microsurgical bypass of the involved arterial segment, and reinforcement or wrapping of the aneurysmal wall are frequently used. The authors report a case with long term(6 years) follow-up results of the circumferential wrapping with sutures-reinforcement for giant fusiform aneurysm of the internal carotid artery. The giant fusiform aneurysm and ideal wrapping materials were discussed with review of literature.
Aneurysm*
;
Arteries
;
Carotid Artery, Internal
;
Endovascular Procedures
;
Follow-Up Studies
;
Humans
;
Neck
;
Parents
;
Sutures
4.Neurenteric Cyst in Upper Thoracic Spinal Canal: Case Report.
Kwan Young SONG ; Hyug Soo KIM ; Myung Hoon JUNG ; Chi Sung AHN ; Sun Wook CHOI ; Il Seung CHOE ; Dong Soo KANG
Journal of Korean Neurosurgical Society 2000;29(8):1080-1084
No abstract available.
Neural Tube Defects*
;
Spinal Canal*
5.A Case of Thoracic Disc Herniation Treated by Transthoracic Transpleural Approach.
Myung Sik KIM ; Il Woo LEE ; Tae Hoon JO ; Jin Un SONG ; Chi Kyung KIM
Journal of Korean Neurosurgical Society 1987;16(1):297-303
Thoracic disc herniation is uncommon and only represents 0.25% to 0.75% of all symptomatic disc lesions. The difficulty in diagnosis has been the one of the major problems in the treatment of thoracic disc herniation. But at now, the use of computed tomography with or without water soluble contrast media makes the diagnosis more acurate. Recently, we diagnosed a case of T4, T5 disc herniation by computed tomography with iopamidol. Operation by transthoracic, transpleural approach was done with microsurgical technique, and the result was good. The case is reviewed and other surgical techniques on the literature is discussed.
Contrast Media
;
Diagnosis
;
Iopamidol
6.A case of thrombotic thrombocytopenic purpura(TTP) presented with acute myocardial infarction(AMI).
Cheol Whan LEE ; Jae Joong KIM ; Sung Jae MYUNG ; Ju Young KIM ; Hae Hyuk CHUNG ; Jae Kwan SONG ; Hyun Sook CHI ; Jong Koo LEE
Korean Circulation Journal 1993;23(3):481-486
A 77-year-old woman was admitted to this hospital for evaluation of chest pain for 3 days. On physical examination, icteric sclerae, inspiratory crackles on both lower lung field and normal heart sounds were observed. Electrocardiograms showed pathologic Q waves with ST elevations in the precordial leads(V1-V4). Chest X-rays showed mild pulmonary edema with anteroseptal wall akinesia. Cardiac enzyme studies were compatible with AMI. Hematologic investigation revealed severe thrombocytopenia and microangiopathic hemolytic anemia. Coagulation profiles were normal. Coombs test, sucrose lysis test, anti-platelet antibody and antinuclear antibody were all negative. Urinalysis showed albuminuria(+++) and microscopic hematuria. Initial therapy with aspirin, nitrate, morphine and prednisolone was started. Ten hours after admission, she developed agitation, aphagia and confusion with progression to coma. Computed tomography of the brain was normal. Five units of fresh frozen plasma were infused. After one day, platelet counts slightly increased. But cardiogenic shock ensued and she died despite cardiopulmonary resuscitation. AMI has not been reported in association with TTP. This patient had no risk factors for coronary artery disease and no previous history of angina. TTP was clinically diagnosed with confidence by excluding other known cause of microangiopathic hemolytic anemia with thrombocytopenia. Coronary angiogram and bone marrow examination could not be performed due to a rapidly fatal course. The etiology of AMI in this patient was not confirmed, but clinical evidence strongly supported etiologic association with TTP.
Aged
;
Anemia, Hemolytic
;
Antibodies, Antinuclear
;
Aspirin
;
Bone Marrow Examination
;
Brain
;
Cardiopulmonary Resuscitation
;
Chest Pain
;
Coma
;
Coombs Test
;
Coronary Artery Disease
;
Dihydroergotamine
;
Electrocardiography
;
Female
;
Heart Sounds
;
Hematuria
;
Humans
;
Lung
;
Morphine
;
Myocardial Infarction
;
Physical Examination
;
Plasma
;
Platelet Count
;
Prednisolone
;
Pulmonary Edema
;
Purpura, Thrombotic Thrombocytopenic
;
Respiratory Sounds
;
Risk Factors
;
Sclera
;
Shock, Cardiogenic
;
Sucrose
;
Thorax
;
Thrombocytopenia
;
Urinalysis
8.A case of juvenile form Pompe's disease manifested as chronic alveolar hypoventilation.
Dong Gyu KIM ; Kisuck JUNG ; Myung Koo LEE ; In Gyu HYUN ; Hwa Jung LIM ; Hong Go SONG ; Je Geun CHI
Journal of Korean Medical Science 1993;8(3):221-224
We describe a case of the juvenile form of Pompe's disease that presented as primary alveolar hypoventilation due to respiratory muscle involvement. This 17-year-old girl had been asymptomatic until this admission, although she had a delayed puberty. Arterial blood gas analysis, pulmonary function test as well as physical findings were compatible with chronic alveolar hypoventilation syndrome. Since she had lower extremity muscle weakness and pseudomyotonic discharge on electromyography a muscle biopsy was done, which revealed glycogen storage disease. The patient was managed successfully with nasal intermittent positive pressure ventilation.
Adolescent
;
Chronic Disease
;
Female
;
Glycogen Storage Disease Type II/*complications/pathology
;
Humans
;
Hypoventilation/*etiology/therapy
;
Intermittent Positive-Pressure Ventilation
;
Muscles/pathology
;
Pulmonary Alveoli
9.Vestibulo-Ocular Reflex according to the Change of Angular Acceleration in Sinusoidal Harmonic Acceleration Test.
Jang Hoon CHI ; Won Sang LEE ; Myung Hyun CHUNG ; Woon Kyo CHUNG ; Jung Jun LEE ; Hae Song LEE
Korean Journal of Otolaryngology - Head and Neck Surgery 1997;40(5):710-718
We investigated the vestibulo-ocular reflex which is followed by the change of angular acceleration in sinusoidal harmonic acceleration test. 20 normal volunteers with no evidence of previous otoneurologic disease were tested. The maximal slow phase eye velocity, gain and asymmetry were obtained in five different amplitudes of rotation, 30degrees, 60degrees, 90degrees, 120degrees and 150degrees with properly fixed conditions such as darkness and the frequency of rotation fixed at 0.05Hz. During each test, we asked the examinees to be alert and keep the eyes open. At least 5 minute interval was given between the tests and recalibrations were done before each test. The results of this test were as follows. 1) The maximal slow phase eye velocities were gradually increased according to the increment of the amplitudes of rotation with the statistical significances(p<0.05). 2) The gains were gradually decreased according to the increment of the amplitudes of rotation between the range of 30degrees and 90degrees with the statistical significances(p<0.05). 3) The asymmetries of each amplitude were the highest(13.6%) at 30degrees and the lowest(6.9%) at 120degrees, but there were no statistical significances(p>0.05). Therefore, from the above results, sinusoidal harmonic acceleration test with the frequency fixed at 0.05Hz, gain is higher when the amplitude of rotation is smaller and the pattern of the nystagmus is more evident when the amplitude of rotation is bigger. But The authors conclude that in order to get the results which are statistically significant, the amplitude of rotation should be lower than 90degrees.
Acceleration*
;
Darkness
;
Healthy Volunteers
;
Reflex, Vestibulo-Ocular*
10.The Internalization of Bacillus Calmette-Guerin (BCG) in Bladder Cancer Cells May be Inhibited by Human beta-defensin 3.
Song Won LIM ; In Ho CHANG ; Tae Hyoung KIM ; Soon Chul MYUNG ; Kyung Do KIM ; Young Tae MOON ; Jin Wook KIM ; Byung Hoon CHI
Korean Journal of Urological Oncology 2015;13(2):75-84
PURPOSE: To investigate whether secretion of human beta-defensin 3 (HBD-3) is induced by bacillus Calmette-Guerin (BCG) and to determine whether HBD-3 affects BCG internalization in bladder cancer cells. MATERIALS AND METHODS: RTPCR analysis was used to determine whether HBD-3 mRNA increases after incubation with BCG. HBD-3 proteins in 5637 and T24 human bladder cancer cell lines were assayed by ELISA. The internalization rate was evaluated by double immunofluorescence assay and confocal microscopy to test the optimal dose of HBD-3 for BCG internalization. We also investigated the difference in internalization rates and cell viability between recombinant HBD-3 protein, anti-HBD-3 antibody, and HBD-3 plus anti-HBD-3 antibody pretreatments. RESULTS: BCG induced HBD-3 mRNA expression and HBD-3 production dose and time-dependently in bladder cancer cells and affected BCG internalization. Pretreatment with recombinant HBD-3 protein lowered internalization of BCG dose-dependently. Moreover, anti-HBD-3 antibody prevented the effect of HBD-3 on BCG internalization in bladder cancer cells. The internalization rate of BCG pretreated with anti-HBD-3 antibody was higher than that in the control. The BCG internalization rate in cells pretreated with anti-HBD-3 antibody plus recombinant HBD-3 protein was higher than that in the control. BCG decreased bladder cancer cell viability, and anti-HBD-3 antibody prevented the inhibitory role of HBD-3 on the anti-proliferative effects of M. bovis BCG in bladder cancer cells. CONCLUSIONS: Bladder cancer cells produce HBD-3 when they are infected by BCG to defend themselves against BCG internalization, which plays an important role during the initiation and propagation of the immunotherapeutic response in bladder cancer cells.
Bacillus*
;
Cell Line
;
Cell Survival
;
Enzyme-Linked Immunosorbent Assay
;
Fluorescent Antibody Technique
;
Humans*
;
Microscopy, Confocal
;
Mycobacterium bovis
;
RNA, Messenger
;
Urinary Bladder Neoplasms*
;
Urinary Bladder*