There have been some 50 reports on the blood pictures of leprosy patients, but all of them have been dealt with the peripheral blood and more over each investigator presented the different data. In order to find cut the typical blood pictures both peripheral and bone marrow as well as the blood pictures between the various types of leprosy and the nature of anemia brought about after the use of D.D.S. derivatives, the author examined the blood of 53 cases of early leprosy patients with the following results: 1. Peripheral Blood Pictures: a. About one third of leprosy patients showel the anemic blood picture and one half of T type leprosy cases gave the anemic picture. Almost all of them were normocytic and hypochromic anemia. b. Shift to the left was found in about 50% of the cases. c. Eosinophilia was observed in the majority of the cases and all of the T type showed eosinophilia. d. There was found lymphocytosis in approximately one third of total cases and half of T type patients showed lymphocytosis. e. Lymphopenia was encountered in one fourth of them and was most frequently seen in L type patients. F. About half of all cases showed monocytopenia. g. Only 10% of patients showed the accelaration in Erythrocyte Sedimentation Rate. 2. Bone Marrow Findings: a. Myeloblastosis was noted in about 50% of them and more frequently seen in T type and I group than the other types. b. There was observed eosinophilia in almost all cases and especially its frequency was higher in T type and I group. c. Lymphocytosis was found in about one third of the total eases and its frequency was highest in L type. whereas in the peripheral blood the lymphocytosis was most frequently seen in T type. d. Plasmocytosis was noted in the majority of the patients and was found in all cases of T type and I group. 3. Seventy percent of the cases showed the increased WBC alkaline phosphatase. 4. No granulomatous changes or any other pathological changes were noted in the histological section of the bone marrow
Alkaline Phosphatase ; Anemia ; Anemia, Hypochromic ; Blood Sedimentation ; Bone Marrow ; Eosinophilia ; Humans ; Leprosy* ; Lymphocytosis ; Lymphopenia ; Research Personnel

A case of familial benign chronic pemphigus in 28 year old male is described which is the first case reported in Korea, and the literature is reviewed The grandmothcr had similar symptoms and the 52 years old father has suffered from the same trouble since puberty The patient's lesions were vesieular, pustular, and crusted patches with erosions which have been persistent since 12 years of age, mainly affecting lateral and posterior sides of the neck, axillary and inguinal regions, lower abdomen, and popliteal fossae symmetrically. Moderate itching was associated with the lesions, which were worse in summer and better in winter. Staphylococcus aureus and p-hemolytic streptococcus were cultured from the lesions and found to be sensitive to aureomycin, terramycin and erythromycin. Biopsy findings showed hyperkeratosis, irregular acanthosis, multilocular suprabasal clefts or bullae with extensive acantholysis. villi formation was also noted. Dyskeratotic changes were present but no mitosis was seen. Local application of 1% hydrocortisone ointment gave temporary improvement but no effect was noted with systemic prednisolone, aureomycin, sulfadrugs, and vitamin A & D, or local treatment with antibiotic ointments.
Abdomen ; Acantholysis ; Adolescent ; Adult ; Biopsy ; Chlortetracycline ; Erythromycin ; Fathers ; Humans ; Hydrocortisone ; Korea ; Male ; Middle Aged ; Mitosis ; Neck ; Ointments ; Oxytetracycline ; Pemphigus, Benign Familial* ; Prednisolone ; Pruritus ; Puberty ; Staphylococcus aureus ; Streptococcus ; Vitamin A

The pneumonia severity index (PSI) and CURB-65 are widely used tools for the prediction of community-acquired pneumonia (CAP). This study was conducted to evaluate validation of severity scoring system including the PSI and CURB-65 scores of Korean CAP patients. In the prospective CAP cohort (participated in by 14 hospitals in Korea from January 2009 to September 2011), 883 patients aged over 18 yr were studied. The 30-day mortalities of all patients were calculated with their PSI index classes and CURB scores. The overall mortality rate was 4.5% (40/883). The mortality rates per CURB-65 score were as follows: score 0, 2.3% (6/260); score 1, 4.0% (12/300); score 2, 6.0% (13/216); score 3, 5.7% (5/88); score 4, 23.5% (4/17); and score 5, 0% (0/2). Mortality rate with PSI risk class were as follows: I, 2.3% (4/174); II, 2.7% (5/182); III, 2.3% (5/213); IV, 4.5% (11/245); and V, 21.7% (15/69). The subgroup mortality rate of Korean CAP patients varies based on the severity scores and CURB-65 is more valid for the lower scores, and PSI, for the higher scores. Thus, these variations must be considered when using PSI and CURB-65 for CAP in Korean patients.
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group ; Cohort Studies ; Community-Acquired Infections/*mortality ; Female ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Pneumonia/*mortality ; Prospective Studies ; Republic of Korea ; *Severity of Illness Index ; Young Adult