OBJECTIVE: The goal of this study is to evaluate the efficacy and outcome of frameless fractionated stereotactic radiotherapy (FSRT) for pituitary adenomas. METHODS: The authors reviewed medical records of 15 patients who were treated by FSRT between January 1997 and December 2002. We used `oint Reference System' of Northwest Medical Physics Center. Three patients received radiotherapy as primary treatment and 12 patients received it postoperatively for residual mass. The mean dose of FSRT was 34.8Gy. Responses of the tumor size, serum hormone level, change of the visual field, and complication were evaluated. The follow-up duration ranged from 6 to 61 months (mean 20.3 months). RESULTS: They consisted of 4 prolactinomas, 3 growth hormone secreting tumors, 2 Cushing's diseases, and 6 nonfunctioning tumors. Overall tumor control rate and the mean tumor volume reduction rate were 86.7% (13/15 patients), 53.6% respectively. Reduction or normalization of hormone level were achieved in 5 of 9 patients, and mean duration was 17.5 months. Visual field defect improved in 3 of 10 patients. Acute complications were temporary headache, dizziness, local alopecia, nausea and vomiting. None of patients showed radionecrosis, panhypopituitarism, and visual impairment. CONCLUSION: Frameless fractionated stereotactic radiotherapy seems to be an effective and safe treatment in pituitary adenoma.
Alopecia ; Dizziness ; Follow-Up Studies ; Growth Hormone ; Headache ; Humans ; Medical Records ; Nausea ; Particle Accelerators* ; Pituitary Neoplasms* ; Prolactinoma ; Radiotherapy* ; Tumor Burden ; Vision Disorders ; Visual Fields ; Vomiting

We report a case of primary leiomyoma of the temporal bone. An 8-year-old girl was hospitalized with a history of progressive enlargement of mass over right temple. On admission, the patient showed about 30x30mm sized, fixed, hard, and bulging mass over right side temporal region. The overlying skin was normal. Her neurologic examinations and laboratory examinations were unremarkable. Computerized tomography images demonstrated an expansile intradiploic isodense lesion with partially eroded outer table and intact inner table involving the squamous portion of right side temporal bone. Magnetic resonance images showed a relatively homogeneously enhancing well-demarcated lesion with isosignal intensity in T1WI and high signal intensity in T2WI. Total removal of eroded outer table and contained relatively hard mass was performed and surgical defect was repaired with poly methyl methacrylate(Codmann Co. CMV 1G(R)). A histopathological diagnosis was leiomyoma.
Child ; Cytochrome P-450 CYP1A1 ; Diagnosis ; Female ; Humans ; Leiomyoma* ; Neurologic Examination ; Skin ; Temporal Bone*