1.Usefulness of Three-phasic Bone Scan in Young Male Patients Suspected of Post-traumatic Reflex Sympathetic Dystrophy Syndrome.
Won Woo LEE ; Tae Uk KIM ; Tae Hoon KIM ; Cheoul Yun JUNG ; Jin Ho MOON
Korean Journal of Nuclear Medicine 2001;35(1):52-60
PURPOSE: In young male patients who suffered several kinds of trauma with subsequent suspicious reflex sympathetic dystrophy syndrome, we performed three-phasic bone scan in order to investigate its usefulness. MATERIALS AND METHODS: Patients with narrow range of age (21-25. mean 22.8+/-1.3, all male) were included with suspicious reflex sympathetic dystrophy syndrome of 12 feet and 5 hands. Only one was bilateral feet case and 16 were ipsilateral (Rt:13, Lt:3). The etiologic traumas were 4 fractures, 4 sprains, 3 blunt trauma, 2 cellulitis, 1 tendon tear, 1 crush injury, 1 overexercise, and 1 unknown. Radiologically 3 showed osteoporotic changes. Three-phasic bone scans were performed 21.2+/-7.3wks after trauma. RESULTS: According to symptom complex, confirmatory reflex sympathetic dystrophy syndrome 4 cases and suspicious 13 were analyzed. All confirmatory cases (100%) showed increased uptake at delay phase with periarticular accentuation. Of confirmatory 4 cases, 2 showed increased uptake in all three phases (perfusion: P, blood pool: B, and delay: D), and other 2 revealed decreased P but, both increased B and D. Of suspicious 13 cases, 9(69.2%) had increased D (4 periarticular and 5 focal), 2 decreased D, and 2 symmetric D. In 12 foot cases, so-called weight bearing patterns - increased contralateral sole at P and B - were revealed in 7(58.3%). CONCLUSION: Diffuse periarticular increased uptake at delay phase of three-phasic bone scan was a compatible finding to reflex sympathetic dystrophy syndrome in young male patients whose symptom complex strongly designated post traumatic reflex sympathetic dystrophy syndrome.
Cellulitis
;
Foot
;
Hand
;
Humans
;
Male*
;
Reflex Sympathetic Dystrophy*
;
Reflex*
;
Sprains and Strains
;
Tendons
;
Weight-Bearing
2.Endothelial Dysfunction after Open Heart Surgery : Role of Oxygen Free Radical and Lipid Peroxidation in Reperfusion Injury.
Young Cheoul DOO ; Eung Jung KIM ; Kyu Hyung RYU ; Chong Yun RIM ; Young Bahk KOH ; Young LEE ; Seung Jung PARK ; Hae Won KIM ; Chan Jeoung PARK
Korean Circulation Journal 1996;26(6):1163-1171
BACKGROUND: Reperfusion of ischemic myocardium is clinically encountered during thrombolytic therapy of acute myocardial infarction, percutaneous transluminal coronary angioplasty(PTCA), and coronary artery bypass graft(CABG). Reperfusion results in endothelial dysfunction characterized by a reduced release of endothelium-derived relaxing factor(EDRF) in animal studies. Studies with experimental animals have emphasized the role of oxygen free radicals and lipid peroxidation in pathophysiology of reperfusion injury and myocardial stunning. The object of this study is to determine whether endothelial dysfunction was developed after open heart surgery and to evaluated the role of oxygen free radical and lipid peroxidation in reperfusion injury. METHODS: The study group was comprised 13 patients who underwent open heart surgery(male/female : 2/11, mean age : 43+/-4 year, Atrial septal defect in 4, Ventricular septal defect in 1, Mitral regurgitation in 2, Tetralogy of Fallot in 1, and Aortic stenosis and Regurgitation with Mitral stenosis in 5 patients). The endothelial function was evaluated with the vasomotor response to acetylcholine and nitroglycerin by change of arterial diameter during the continous infusion of acetylcholin, from 10(-9) to 10(-6) molar concentration to the coronary artery and intracoronary injection of 200microg nitroglycerin after acetylcholine infusion. The infusion study was performed before and 10 days after surgery. For analysis of the role of oxygen free radical and lipid peroxidation in reperfusion injury, blood samples for malondialdehyde and neutrophil respiratory burst test(hydrogen peroxide amount of neutrophils) were obtained in pre-declamping of aorta and 5 min, 10 min, and 20 min after declamping of aorta from coronary sinus. RESULTS: 1) The vasoconstrictor response to acetylcholine, 10(-9) to 10(-6)M concentration, at proximal and distal left anterior descending coronary artery, were increased significantly in post-operation infusion study but there was no singnificant difference in vasodilator response to nitroglycerin. 2) The mean absorbance value of malondialdehyde(MDA) in pre-declamping and 5min, 10min, and 20min after reperfusion were 96+/-12, 73+/-12, 89+/-11 and 77+/-12, respectively. There was no significant difference in plasma MDA level and hydrogen peroxide amount of neutrophils after reperfusion(aortic declamping). CONCLUSION: These data suggest that endothelium dependent vascular relaxation is impaired in patients with open heart surgery and post-ischemic reperfusion injury may be responsible for the abnormal response. But we did not determine the role of lipid peroxidation and oxygen free radical in reperfusion injury.
Acetylcholine
;
Animals
;
Aorta
;
Aortic Valve Stenosis
;
Coronary Artery Bypass
;
Coronary Sinus
;
Coronary Vessels
;
Endothelium
;
Free Radicals
;
Heart Septal Defects, Atrial
;
Heart Septal Defects, Ventricular
;
Heart*
;
Humans
;
Hydrogen Peroxide
;
Lipid Peroxidation*
;
Malondialdehyde
;
Mitral Valve Insufficiency
;
Mitral Valve Stenosis
;
Molar
;
Myocardial Infarction
;
Myocardial Stunning
;
Myocardium
;
Neutrophils
;
Nitroglycerin
;
Oxygen*
;
Plasma
;
Relaxation
;
Reperfusion Injury*
;
Reperfusion*
;
Respiratory Burst
;
Tetralogy of Fallot
;
Thoracic Surgery*
;
Thrombolytic Therapy
3.Endothelial Dysfunction after Open Heart Surgery : Role of Oxygen Free Radical and Lipid Peroxidation in Reperfusion Injury.
Young Cheoul DOO ; Eung Jung KIM ; Kyu Hyung RYU ; Chong Yun RIM ; Young Bahk KOH ; Young LEE ; Seung Jung PARK ; Hae Won KIM ; Chan Jeoung PARK
Korean Circulation Journal 1996;26(6):1163-1171
BACKGROUND: Reperfusion of ischemic myocardium is clinically encountered during thrombolytic therapy of acute myocardial infarction, percutaneous transluminal coronary angioplasty(PTCA), and coronary artery bypass graft(CABG). Reperfusion results in endothelial dysfunction characterized by a reduced release of endothelium-derived relaxing factor(EDRF) in animal studies. Studies with experimental animals have emphasized the role of oxygen free radicals and lipid peroxidation in pathophysiology of reperfusion injury and myocardial stunning. The object of this study is to determine whether endothelial dysfunction was developed after open heart surgery and to evaluated the role of oxygen free radical and lipid peroxidation in reperfusion injury. METHODS: The study group was comprised 13 patients who underwent open heart surgery(male/female : 2/11, mean age : 43+/-4 year, Atrial septal defect in 4, Ventricular septal defect in 1, Mitral regurgitation in 2, Tetralogy of Fallot in 1, and Aortic stenosis and Regurgitation with Mitral stenosis in 5 patients). The endothelial function was evaluated with the vasomotor response to acetylcholine and nitroglycerin by change of arterial diameter during the continous infusion of acetylcholin, from 10(-9) to 10(-6) molar concentration to the coronary artery and intracoronary injection of 200microg nitroglycerin after acetylcholine infusion. The infusion study was performed before and 10 days after surgery. For analysis of the role of oxygen free radical and lipid peroxidation in reperfusion injury, blood samples for malondialdehyde and neutrophil respiratory burst test(hydrogen peroxide amount of neutrophils) were obtained in pre-declamping of aorta and 5 min, 10 min, and 20 min after declamping of aorta from coronary sinus. RESULTS: 1) The vasoconstrictor response to acetylcholine, 10(-9) to 10(-6)M concentration, at proximal and distal left anterior descending coronary artery, were increased significantly in post-operation infusion study but there was no singnificant difference in vasodilator response to nitroglycerin. 2) The mean absorbance value of malondialdehyde(MDA) in pre-declamping and 5min, 10min, and 20min after reperfusion were 96+/-12, 73+/-12, 89+/-11 and 77+/-12, respectively. There was no significant difference in plasma MDA level and hydrogen peroxide amount of neutrophils after reperfusion(aortic declamping). CONCLUSION: These data suggest that endothelium dependent vascular relaxation is impaired in patients with open heart surgery and post-ischemic reperfusion injury may be responsible for the abnormal response. But we did not determine the role of lipid peroxidation and oxygen free radical in reperfusion injury.
Acetylcholine
;
Animals
;
Aorta
;
Aortic Valve Stenosis
;
Coronary Artery Bypass
;
Coronary Sinus
;
Coronary Vessels
;
Endothelium
;
Free Radicals
;
Heart Septal Defects, Atrial
;
Heart Septal Defects, Ventricular
;
Heart*
;
Humans
;
Hydrogen Peroxide
;
Lipid Peroxidation*
;
Malondialdehyde
;
Mitral Valve Insufficiency
;
Mitral Valve Stenosis
;
Molar
;
Myocardial Infarction
;
Myocardial Stunning
;
Myocardium
;
Neutrophils
;
Nitroglycerin
;
Oxygen*
;
Plasma
;
Relaxation
;
Reperfusion Injury*
;
Reperfusion*
;
Respiratory Burst
;
Tetralogy of Fallot
;
Thoracic Surgery*
;
Thrombolytic Therapy
4.The Prognostic Value of Serum Troponin-T in Unstable Angina.
Jae Myung LEE ; Young Cheoul DOO ; Soon Hee KOH ; Dong Jin OH ; Kyu Hyung RYU ; Chong Yun RIM ; Young Bahk KOH ; Young LEE ; Jung Bae PARK
Korean Circulation Journal 1995;25(4):764-768
BACKGROUND: Unstable angina is a critical phase of ischemic heart disease, but there are no reliable noninvasive methods of assigning patients to different prognostic actegories. Recently cardiac Troponin-T has been developed as a new myocardial specific marker, especially myocardial injury. We investigated the value of the Troponin-T in unstable angina to determine whether the increase of cardiac Troponin-T might be a useful predictor of prognosis. METHODS: Unstable angina is defined as Braunwald classification(Class I, II, III). CLass I is new onset of severe angina or accelerated angina and no rest pain, class II is angina at rest but not within preceding 48 hour, and class III is angina at rest within 48 hour. We studied 16 cases of unstable angina(male:10, mean age:57+/-2year). We measured Troponin-T and CK-MB at admission, after 6 hours, and every 8 hour for 2 days. For the determination of serum Troponin-T, an enzyme immunosorbent assay (Boehringer Mannheim, ES 300 analyzer) was used. Above 0.1ng/ml was regarded as positive. During the admission, we investigated the myocardial infartion, sudden death, and the need of emergency PTCA and CABG. RESULTS: 1) Among 16 unstable angina patients, there are 12 patients in Class I(range 0.001-0.13, mean SD 0.04 0.01, median 0.02ng/ml) and 4 patients in Class III(range 0.03-1.56, mean SD 0.39 0.2, median 0.27ng/ml) and 4 patients showed positive value of Troponin-T. One was in Class I and the others were in Class III. 2) During the admission, one patient expired due to cardiogenic shock preceding inferior myocardial infarction, and 2 patients progressed non-Q wave myocardial infarction(NQMI). These 3 patients were in unstable angina Class III and had positive Troponin-T value. In Class I, one patient performed emergency CABG due to consistent chest pain at the sixth hospital day. These patient had negative Troponin-T value. 3) CK-MB increased in one patient with NQMI, and the other patients were not increased. CONCLUSION: Cardiac Troponin-T in serum appears to be a more sensitive indicator of myocardial cell injury than serum creatine Kinase MD activity, and its detection in the circulation may be a useful porgnostic indicator in patients with unstable angina.
Angina, Unstable*
;
Chest Pain
;
Creatine Kinase
;
Death, Sudden
;
Emergencies
;
Humans
;
Inferior Wall Myocardial Infarction
;
Myocardial Ischemia
;
Prognosis
;
Shock, Cardiogenic
;
Troponin T*
5.Prosthetic Valve Endocarditis.
Wang Seong RYU ; Cheoul Ho KIM ; Jeong Hyun KIM ; Myoung Mook LEE ; Young Bae PARK ; Yun Sik CHOI ; Jung Don SEO ; Young Woo LEE ; Kyung Pil SEO
Korean Circulation Journal 1984;14(1):29-36
Prosthetic valve endocarditis(PVE) is not infrequent and one of the serious complications of cardiac valve replacement despite advances in antimicrobial therapy, diagnostic techniquens and surgical procedures. Although the incidence of PVE may be declining, the absolute number of cases of this infection is increasing. In patients with a prosthetic valve, fever, a regurgitant heart murmur, peripheral manifestations of infective endocarditis and postitive blood cultures, the diagnosis of PVE is evident. We have reviewed our experience with 13 patients with PVE from October 1976 through August 1983. During this period valve replacements were performed in 686 patients, with an infection rate of 1.9%. PVE currently accounts for approximately 14% of the total number of cases of infective endocarditis seen at Seoul national University Hospital. PVE occurred more often after multiple valve replacement than after replacement of single valve alone. Blood cultures were positive in 69% cases of PVE. Systemic emboli could be seen in 54% of patients with PVE and overall mortality was about 23%.
Diagnosis
;
Endocarditis*
;
Fever
;
Heart Murmurs
;
Heart Valves
;
Humans
;
Incidence
;
Mortality
;
Seoul
6.A Case of Congenital Hepatic Fibrosis Presented with Symptom of Acute Cholangitis.
Chang Soo CHOI ; Hyo Jeong OH ; Byung Soo KIM ; Eun Young JO ; Tae Hyeon KIM ; Suck Chei CHOI ; Haak Cheoul KIM ; Ki Jung YUN
The Korean Journal of Gastroenterology 2005;46(3):237-241
Congenital hepatic fibrosis (CHF) is an autosomal recessive disease, presenting principally in children or young adults with portal hypertension, and infrequently associated with cholangitis. It is associated with renal malformation and Caroli's disease. The diagnosis of CHF is usually confirmed by its typical histological features. Cholangitis is a severe and frequently fatal complication. We report a 22-year-old man with congenital hepatic fibrosis who showed the cholangitis without radiological features of cystic dilatation or stone of intrahepatic ducts.
Acute Disease
;
Adult
;
Cholangitis/*complications/diagnosis
;
Humans
;
Liver Cirrhosis/*complications/*congenital/diagnosis
;
Male
7.Myocardial Synchronicity: As a Predictor of Left Ventricle Function Recovery in Severe Congestive Heart Failure.
Goo Yeong CHO ; Kwang Pyo SON ; Woo Jung PARK ; Sung Woo HAN ; Young Cheoul DOO ; Dong Jin OH ; Chong Yun RHIM ; Yung LEE
Korean Circulation Journal 2003;33(8):687-694
BACKGROUND AND OBJECTIVES: The recovery of the left ventricular ejection fraction (LVEF) appeared to be prognostic of survival in congestive heart failure (CHF). The aim of our study was to evaluate the parameters that appear to predict the LVEF recovery in CHF. SUBJECTS AND METHODS: Forty-nine patients, with CHF and a LVEF< 35%, were enrolled. Doppler myocardial imaging was performed on 5-basal and 5-mid segments in order to assess the systolic duration, the time from the R-wave to the peak systolic velocity (RS time) and the time from the R-wave to the peak early diastolic velocity (RE time). The standard deviation (SD) of the RS time was an indicator of the 'systolic synchronicity'. After at least 3 months of full medical therapy, a follow-up echocardiography was performed. According to the changes in the LVEF, the patients were divided into groups I (< 5%, n=29) and II (> or =5%, n=20). RESULTS: The baseline clinical and echocardiographic parameters were similar in both groups. In group II, the LV end-systolic and end-diastolic volumes were decreased, but the LVEF was increased by up to 44% at the follow-up. The right ventricular annulus velocity (group I: 6.7+/-2.1 vs. group II: 8.0+/-2.0 cm/sec, p< 0.05), the use of beta-blocker (69 vs. 100%, p< 0.05) and the SD of the RS time (46+/-21 vs. 21+/-12, p< 0.01) were significantly different between the two groups. However, the systolic duration and the SD of the RE time were similar in the two groups. From a multivariate analysis, only the SD of the RS time was an independent predictor of the LVEF recovery. CONCLUSION: Myocardial systolic synchronicity is an important predictor of the LVEF recovery.
Echocardiography
;
Estrogens, Conjugated (USP)*
;
Follow-Up Studies
;
Heart Failure*
;
Heart Ventricles*
;
Humans
;
Multivariate Analysis
;
Recovery of Function*
;
Stroke Volume
8.A case of hepatocellular carcinoma invading the gallbladder misdiagnosed as a primary gallbladder carcinoma.
Han Seung RYU ; Eui Tae HWANG ; Chang Soo CHOI ; Tae Hyeon KIM ; Haak Cheoul KIM ; Ki Jung YUN ; Dong Eun PARK
The Korean Journal of Hepatology 2009;15(1):80-84
Extrahepatic metastasis of hepatocellular carcinoma (HCC) is occasionally seen in the lung, bone, adrenal gland, and lymph nodes. It is well known that HCC sometimes invades the biliary system. Since there is no peritoneum between the gallbladder and the liver fossa, a gallbladder cancer easily invades the liver; however, HCC seldom invades the gallbladder because it rarely destroys the muscle layer or the collagen fibers of the gallbladder wall. Routes of gallbladder metastasis of HCC include direct invasion, extension to the biliary system, and invasion of the adjacent hepatic vascular system. Some cases of gallbladder metastasis of HCC without direct invasion have been reported. We report here a case of HCC that directly invaded the gallbladder, and that resembled gallbladder carcinoma invading the liver.
Adult
;
Carcinoma, Hepatocellular/*diagnosis/pathology/ultrasonography
;
Diagnosis, Differential
;
Gallbladder Neoplasms/diagnosis/*secondary
;
Humans
;
Liver Neoplasms/*diagnosis/pathology/ultrasonography
;
Male
;
Neoplasm Invasiveness
;
Tomography, X-Ray Computed
9.Two cases of Ticlopidine-induced neutropenia in patients with cardiovascular disease.
Gyeong Soo CHAE ; Hee Seung YOO ; Jae Hwan JEE ; Jong Min LEE ; Jin Seok AHN ; Jung Ae LEE ; Young Suk PARK ; Young Cheoul DOO ; Kyoo Rok HAN ; Dong Jin OH ; Chong Yun RHIM
Korean Circulation Journal 1998;28(2):280-283
Ticlopidine is an antiplatelet agent used as a drug to prevent the recurrence of cerebral infarction or ischemic heart disease. Close attention has recently been paid to the superiority of this drug to aspirin in the prevention of stroke. Its mechanism of action differs from aspirin, dipyridamole, and sulfinpyrazone. Inhibition of the adenosine diphosphate induced pathway of platelet aggregation, along with the activation of adenylate cyclase and suppression of platelet-activating factor and thromboxane A2, are the postulated mechanisms of action of ticlopidine. Because ticlopidine causes neutropenia and agranulocytosis in roughly 1% of treated patients, usually within the first 3 months of treatment, this drug has been reserved for patients intolerant to aspirin therapy. We reported two cases of ticlopidine-induced neutropenia and one patient hospitalized with severe neutropenia and pneumonia.
Adenosine Diphosphate
;
Adenylyl Cyclases
;
Agranulocytosis
;
Aspirin
;
Cardiovascular Diseases*
;
Cerebral Infarction
;
Dipyridamole
;
Humans
;
Myocardial Ischemia
;
Neutropenia*
;
Platelet Aggregation
;
Pneumonia
;
Recurrence
;
Stroke
;
Sulfinpyrazone
;
Thromboxane A2
;
Ticlopidine
10.Two cases of Ticlopidine-induced neutropenia in patients with cardiovascular disease.
Gyeong Soo CHAE ; Hee Seung YOO ; Jae Hwan JEE ; Jong Min LEE ; Jin Seok AHN ; Jung Ae LEE ; Young Suk PARK ; Young Cheoul DOO ; Kyoo Rok HAN ; Dong Jin OH ; Chong Yun RHIM
Korean Circulation Journal 1998;28(2):280-283
Ticlopidine is an antiplatelet agent used as a drug to prevent the recurrence of cerebral infarction or ischemic heart disease. Close attention has recently been paid to the superiority of this drug to aspirin in the prevention of stroke. Its mechanism of action differs from aspirin, dipyridamole, and sulfinpyrazone. Inhibition of the adenosine diphosphate induced pathway of platelet aggregation, along with the activation of adenylate cyclase and suppression of platelet-activating factor and thromboxane A2, are the postulated mechanisms of action of ticlopidine. Because ticlopidine causes neutropenia and agranulocytosis in roughly 1% of treated patients, usually within the first 3 months of treatment, this drug has been reserved for patients intolerant to aspirin therapy. We reported two cases of ticlopidine-induced neutropenia and one patient hospitalized with severe neutropenia and pneumonia.
Adenosine Diphosphate
;
Adenylyl Cyclases
;
Agranulocytosis
;
Aspirin
;
Cardiovascular Diseases*
;
Cerebral Infarction
;
Dipyridamole
;
Humans
;
Myocardial Ischemia
;
Neutropenia*
;
Platelet Aggregation
;
Pneumonia
;
Recurrence
;
Stroke
;
Sulfinpyrazone
;
Thromboxane A2
;
Ticlopidine