1.Delayed-Onset Anaphylaxis Caused by IgE Response to Influenza Vaccination
Min Jung KIM ; Doo Hee SHIM ; Hye Ran CHA ; Cheong Bi KIM ; Soo Yeon KIM ; Jeon Han PARK ; Myung Hyun SOHN ; Jae Myun LEE ; Kyung Won KIM
Allergy, Asthma & Immunology Research 2020;12(2):359-363
Influenza vaccine-associated anaphylaxis is a very rare allergic reaction to vaccines, but the most concerning and life-threatening adverse reaction. Although the safety of influenza vaccines has been well documented, occasional cases of anaphylaxis in vaccinated patients have been reported. In this study, we analyzed the immunoglobulin E (IgE) response to whole influenza vaccines in a pediatric case of delayed-onset anaphylaxis after influenza vaccination. The patient showed elevated specific IgE levels against whole influenza vaccines, especially with split virion from egg-based manufacturing process. Specific IgE levels to influenza vaccines showed decreased over. We evaluated a causal relationship between influenza vaccine and anaphylaxis event by enzyme-linked immunosorbent assay. Delayed-onset anaphylaxis after influenza vaccination can occur in children without predisposing allergic diseases. In addition, the results suggested that formulation and production system of influenza vaccines could affect the probability of severe allergic reaction to vaccines.
Anaphylaxis
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Child
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Drug Hypersensitivity
;
Enzyme-Linked Immunosorbent Assay
;
Humans
;
Hypersensitivity
;
Hypersensitivity, Delayed
;
Immunoglobulin E
;
Immunoglobulins
;
Influenza Vaccines
;
Influenza, Human
;
Vaccination
;
Vaccines
;
Virion
2.Dronedarone hydrochloride enhances the bioactivity of endothelial progenitor cells via regulation of the AKT signaling pathway
Jian ZHANG ; Thi Hong VAN LE ; Vinoth Kumar RETHINESWARAN ; Yeon-Ju KIM ; Woong Bi JANG ; Seung Taek JI ; Thanh Truong GIANG LY ; Jong Seong HA ; Jisoo YUN ; Jae Hun CHEONG ; Jinsup JUNG ; Sang-Mo KWON
The Korean Journal of Physiology and Pharmacology 2021;25(5):459-466
Cardiovascular disease (CVD) and its complications are the leading cause of morbidity and mortality in the world. Because of the side effects and incomplete recovery from current therapy, stem cell therapy emerges as a potential therapy for CVD treatment, and endothelial progenitor cell (EPC) is one of the key stem cells used for therapeutic applications. The effect of this therapy required the expansion of EPC function. To enhance the EPC activation, proliferation, and angiogenesis using dronedarone hydrochloride (DH) is the purpose of this study. DH received approval for atrial fibrillation treatment and its cardiovascular protective effects were already reported. In this study, DH significantly increased EPC proliferation, tube formation, migration, and maintained EPCs surface marker expression. In addition, DH treatment up-regulated the phosphorylation of AKT and reduced the reactive oxygen species production. In summary, the cell priming by DH considerably improved the functional activity of EPCs, and the use of which might be a novel strategy for CVD treatment.
3.Dronedarone hydrochloride enhances the bioactivity of endothelial progenitor cells via regulation of the AKT signaling pathway
Jian ZHANG ; Thi Hong VAN LE ; Vinoth Kumar RETHINESWARAN ; Yeon-Ju KIM ; Woong Bi JANG ; Seung Taek JI ; Thanh Truong GIANG LY ; Jong Seong HA ; Jisoo YUN ; Jae Hun CHEONG ; Jinsup JUNG ; Sang-Mo KWON
The Korean Journal of Physiology and Pharmacology 2021;25(5):459-466
Cardiovascular disease (CVD) and its complications are the leading cause of morbidity and mortality in the world. Because of the side effects and incomplete recovery from current therapy, stem cell therapy emerges as a potential therapy for CVD treatment, and endothelial progenitor cell (EPC) is one of the key stem cells used for therapeutic applications. The effect of this therapy required the expansion of EPC function. To enhance the EPC activation, proliferation, and angiogenesis using dronedarone hydrochloride (DH) is the purpose of this study. DH received approval for atrial fibrillation treatment and its cardiovascular protective effects were already reported. In this study, DH significantly increased EPC proliferation, tube formation, migration, and maintained EPCs surface marker expression. In addition, DH treatment up-regulated the phosphorylation of AKT and reduced the reactive oxygen species production. In summary, the cell priming by DH considerably improved the functional activity of EPCs, and the use of which might be a novel strategy for CVD treatment.