Annular pancreas is a rare congenital malformation consisting of pancreatic tissue surrounding the descending portion of the duodenum and induces intestinal obstruction. This is caused by incomplete rotation of the ventral pancreatic bud. In children, the annular pancreas is also associated with trisomy 21 and other congenital diseases such as Meckel’s diverticulum, intestinal, or cardiac malformations. Here we presented a rare case of the annular pancreas with Meckel’s diverticulum identified by the abdominal exploration of an 8-day-old girl who suffered from projectile bilious vomiting. A plain abdominal radiograph showed a ‘double-bubble sign’ with air in the stomach and duodenum, and the upper gastrointestinal series showed a dilated proximal duodenum, with partial obstruction of the descending duodenum. The exploration revealed an annular pancreas, Meckel’s diverticulum, and Ladd’s band without large bowel malrotation. Subsequently, she ate well and was discharged on the 27th hospital day.

Annular pancreas is a rare congenital malformation consisting of pancreatic tissue surrounding the descending portion of the duodenum and induces intestinal obstruction. This is caused by incomplete rotation of the ventral pancreatic bud. In children, the annular pancreas is also associated with trisomy 21 and other congenital diseases such as Meckel’s diverticulum, intestinal, or cardiac malformations. Here we presented a rare case of the annular pancreas with Meckel’s diverticulum identified by the abdominal exploration of an 8-day-old girl who suffered from projectile bilious vomiting. A plain abdominal radiograph showed a ‘double-bubble sign’ with air in the stomach and duodenum, and the upper gastrointestinal series showed a dilated proximal duodenum, with partial obstruction of the descending duodenum. The exploration revealed an annular pancreas, Meckel’s diverticulum, and Ladd’s band without large bowel malrotation. Subsequently, she ate well and was discharged on the 27th hospital day.

Fractures of the lateral process of the talus (LPT) are considered rare, accounting for less than 1% of all ankle injuries in the general population. These fractures are nearly 15 times more likely to occur in snowboarders. Recently, the number of population who started enjoying cable-wakeboard is increasing and this sport may cause fracture of the LPT by axial loading occur on the LPT while boarding or trick. We report on a case of involving LPT fracture during cable-wakeboard trick with successful screw osteosynthesis.
Ankle Injuries ; Skiing ; Sports ; Talus

The interest in aging and anti-aging research has increased significantly in recent years, leading to rapid expansion in the anti-aging market. Aging is associated with gradual physiological changes and an elevated risk of age-related ailments, and is divided into three categories: usual aging, successful aging, and pathological aging. Each category is associated with distinct implications for health and well-being. Middle-aged women who experience accelerated physiological changes that are intensified by hormonal changes during menopause are particularly vulnerable to chronic diseases. The importance of anti-aging tests is increasing since they enable early identification and intervention. Telomere length, oxidative stress markers, DNA repair markers, RNA profiles, inflammatory markers, hormone levels, and epigenetic changes are some molecular parameters studied to test for aging. In addition, a thorough review of middle-aged women’s anti-aging profiles also includes monitoring the vitamin D levels and assessing the effects of endocrinedisrupting substances on ovarian aging. The application of personalized medicine paradigms, utilizing various diagnostic methods, will enable accurate risk prediction and the implementation of focused therapies, ultimately promoting the extension of health span and the improvement of quality of life in middle-aged women.

The interest in aging and anti-aging research has increased significantly in recent years, leading to rapid expansion in the anti-aging market. Aging is associated with gradual physiological changes and an elevated risk of age-related ailments, and is divided into three categories: usual aging, successful aging, and pathological aging. Each category is associated with distinct implications for health and well-being. Middle-aged women who experience accelerated physiological changes that are intensified by hormonal changes during menopause are particularly vulnerable to chronic diseases. The importance of anti-aging tests is increasing since they enable early identification and intervention. Telomere length, oxidative stress markers, DNA repair markers, RNA profiles, inflammatory markers, hormone levels, and epigenetic changes are some molecular parameters studied to test for aging. In addition, a thorough review of middle-aged women’s anti-aging profiles also includes monitoring the vitamin D levels and assessing the effects of endocrinedisrupting substances on ovarian aging. The application of personalized medicine paradigms, utilizing various diagnostic methods, will enable accurate risk prediction and the implementation of focused therapies, ultimately promoting the extension of health span and the improvement of quality of life in middle-aged women.

The interest in aging and anti-aging research has increased significantly in recent years, leading to rapid expansion in the anti-aging market. Aging is associated with gradual physiological changes and an elevated risk of age-related ailments, and is divided into three categories: usual aging, successful aging, and pathological aging. Each category is associated with distinct implications for health and well-being. Middle-aged women who experience accelerated physiological changes that are intensified by hormonal changes during menopause are particularly vulnerable to chronic diseases. The importance of anti-aging tests is increasing since they enable early identification and intervention. Telomere length, oxidative stress markers, DNA repair markers, RNA profiles, inflammatory markers, hormone levels, and epigenetic changes are some molecular parameters studied to test for aging. In addition, a thorough review of middle-aged women’s anti-aging profiles also includes monitoring the vitamin D levels and assessing the effects of endocrinedisrupting substances on ovarian aging. The application of personalized medicine paradigms, utilizing various diagnostic methods, will enable accurate risk prediction and the implementation of focused therapies, ultimately promoting the extension of health span and the improvement of quality of life in middle-aged women.

Noonan syndrome is characterized by short stature, typical facial dysmorphology, and congenital heart defects. The main facial features of Noonan syndrome are hypertelorism with down-slanting palpebral fissures, ptosis, and low-set posteriorly-rotated ears with a thickened helix. The cardiovascular defects most commonly associated with this condition are pulmonary stenosis and hypertrophic cardiomyopathy. Other associated features are webbed neck, chest deformity, mild intellectual deficit, cryptorchidism, poor feeding in infancy, bleeding tendency, and lymphatic dysplasias. The patient is a 10-year-old boy. He had experienced repeated febrile convulsions. He had typical facial features, a short stature, chest deformity, cryptorchidism, vesicoureteral reflux, and mental retardation. His language and motor development were delayed. When he went to school, it was difficult for him to pay attention, follow directions, and organize tasks. He also displayed behavior such as squirming, leaving his seat in class, and running around inappropriately. Clinical observation is important for the diagnosis, so we report a patient who was diagnosed with Noonan syndrome, mental retardation, and attention-deficit hyperactivity disorder.
Cardiomyopathy, Hypertrophic ; Child ; Congenital Abnormalities ; Cryptorchidism ; Ear ; Heart Defects, Congenital ; Hemorrhage ; Humans ; Hypertelorism ; Intellectual Disability ; Male ; Neck ; Noonan Syndrome ; Pulmonary Valve Stenosis ; Running ; Seizures, Febrile ; Thorax ; Vesico-Ureteral Reflux

No abstract available.
Korea ; Thyroid Gland

Epidermal inclusion cysts are benign cutaneous or subcutaneous lesions, which are filled with lamellated keratin and lined with stratified squamous epithelium. They are commonly found in the face, neck, trunk, and rare in the breast. Although most epidermal inclusion cysts are harmless, ruptured cysts can lead to infection or abscess and which often require surgical removal. Only few cases of ruptured epidermal cyst in breast have been reported, and furthermore, occurrence of ruptured epidermal cyst in the breast parenchyma is very rare. We now report a rare case of a ruptured epidermal inclusion cyst arising in the breast parenchyma.
Abscess* ; Breast* ; Epidermal Cyst ; Epithelium ; Neck

BACKGROUND: Loss of heterozygosity (LOH) and mutation of the p16 tumor suppressor gene have been detected in non-Hodgkin's lymphomas (NHLs). Recently, hypermethylation of the p16 gene has been reported. The role of p16 gene alterations in the genesis of NHLs and their high-grade transformations require explanation. METHODS: LOH of D9S171 and IFNA microsatellite markers, DNA hypermethylation, and mutation of exon 1 and 2A were assessed in 43 cases of NHLs. The genetic abnormalities were compared with the protein expression by immunohistochemistry, and they were evaluated according to the histologic subtypes, grades and immunophenotypes. RESULTS: DNA hypermethylation was the most common p16 gene abnormality and was found in 30 of 39 cases (76.9%). Eight cases (18.6%) showed LOH in one or both microsatellite markers, and five cases (11.6%) showed mutations in exon 1 or 2A. Loss of protein expression was seen in 17 cases (39.5%) and was associated with mutation and LOH. Loss of protein was more frequent in high-grade lymphomas than in low-grade lymphomas. CONCLUSION: These results suggest that the functional loss of the p16 gene contributes to the development of NHLs, especially to the development of high-grade lymphomas.
DNA ; Exons ; Genes, p16* ; Genes, Tumor Suppressor ; Immunohistochemistry ; Loss of Heterozygosity ; Lymphoma ; Lymphoma, Non-Hodgkin* ; Microsatellite Repeats