1.A survey of chromosome studies in 466 cases.
In Sung LEE ; Cheol seung SON ; Ki Bok KIM
Journal of the Korean Pediatric Society 1985;28(2):160-168
No abstract available.
2.Capsular polysaccharide typing of domestic mastitis-causing Staphylococcus aureus strains and its potential exploration of bovine mastitis vaccine developmen. I. capsular polysaccharide typing, isolation and purification of the strains.
Hong Ryul HAN ; Son Il PAK ; Seung Won KANG ; Woo Seog JONG ; Cheol Jong YOUN
Journal of Veterinary Science 2000;1(1):53-60
One hundred seven isolates of Staphylococcus aureus from bovine mastitis were investigated for colony morphology in serum-soft agar (SSA), autoagglutination in salt, and capsular serotype. Capsular polysaccharide (CP) was purified and quantified from the extracts of clinical isolates. Overall, 89 isolates (83.2%) were diffuse in the SSA, without any difference in the proportion of diffuse colony between type 5 and type 8 strains. Some strains exhibited compact colonies in the SSA and expressed CP as determined by an enzyme-linked immunosorbent assay, indicating that compact morphology does not exclude encapsulation. The majority of the strains (11/12) showed autoagglutination in the salt aggregation test. The serotype 336 accounted for 46.7% of the isolates followed by serotype 5 (12.1%) and serotype 8 (12.1%). Particularly, twenty-six (24.3%) isolates reacted with two serotypes; 7 for type 8/336 and 19 for type 5/336. Five isolates (4.7%) were nontypeable with monoclonal antibodies specific for CP serotype 5, 8, or 336. The CP concentration in culture supernatants varied with the serotypes, and the total amount of CP produced by cells grown in a liquid medium was much less than that produced by cells grown on a solid medium. The Western blotting indicated that the CP bands of S. aureus serotype 5 and 8 were ranged in the molecular mass of 58-84 kilodalton (kDa), with additional bands in the region of approximately >or= 48 or
3.A Synergistic Effect of Apomorphine on Sildenafil Induced Penile Erection in Conscious Rabbits.
Jae Young PARK ; Hwan cheol SON ; Jae Seung PAICK
Korean Journal of Urology 2003;44(5):452-459
PURPOSE: The aim of this study was to demonstrate that the combined systemic administration of apomorphine (APO) and sildenafil have a synergistic effect on the erection in conscious rabbits. MATERIALS AND METHODS: The erections of the male New Zealand White rabbits (2-3kg, n=12) were assessed by measuring the length of the uncovered penile mucosa (LUPM) and duration of the erection, both before and after the intravenous administration of agents. After the injection of APO (0, 0.05, 0.1, 0.4mg/kg), sildenafil was administered intravenously in a dose-response manner (0.5, 1, 5mg/kg), followed by measurements for 0-120 minutes. In additional experiments, the effect of increasing the dosages of sildenafil, combined with APO, on blood pressure were evaluated. RESULTS: The intravenous administration of sildenafil caused a concentration dependent increase in the LUPM. There was a statistically significant increase in the LUPM with the administration of APO compared with no administration. The dosages of sildenafil and APO showing the greatest efficacy of sildenafil potentiation were 1mg/kg and 0.1 mg/kg, respectively. The intravenous administration of APO at a dose of 0.1mg/kg was more effective than those of 0.05 and 0.4mg/kg, with dosages of sildenafil of 0.5 and 1mg/kg. There was no additional increase in the duration of erection on the administration of APO. The intravenous administration of sildenafil caused a concentration dependent decrease in blood pressure, but there was no additional decrease on administration of the APO. CONCLUSIONS: We have shown that apomorphine elicits a stronger response on the erection induced by sildenafil in conscious rabbits, with no additional decrease in blood pressure.
Administration, Intravenous
;
Apomorphine*
;
Blood Pressure
;
Humans
;
Male
;
Mucous Membrane
;
Penile Erection*
;
Rabbits*
;
Sildenafil Citrate
4.Changes of Visual Acuity and Ophthalmic Symptoms in Female Workers examining Silver Plating Products.
Seung Ho RYU ; Jeong Il SON ; Soo Jin LEE ; Jae Cheol SONG
Korean Journal of Preventive Medicine 1997;30(3):567-576
To evaluate the effects of reflected glare on eyes, authors assessed the periodic health examination(1991-1996) and self-administered questionnaire data of a semiconductor producing company. The 13 lead frame(LF) department workers have been exposed to high reflected glare in the process for examining the silver plating products. We compared the data of connector(14) and clerical(12) workers as the non-exposed ones. Among LF department workers, 100% felt their visual acuity worsened(connector:81.8%, clerical:85.7%), and 70% had worn the glasses or contact lenses(connector :14.3 %, clerical :40%) since working at the company. Major ophthalmic symptoms of the LF workers are asthenopia, tearing, decreased visual acuity, congestion and glare. Decrease of visual acuity by Hahn's line change of the LF workers is significantly high during a 5-year follow-up(p<0.05 by simple regression) compared with connector, clerical workers.
Asthenopia
;
Estrogens, Conjugated (USP)
;
Eyeglasses
;
Female*
;
Glare
;
Glass
;
Humans
;
Surveys and Questionnaires
;
Semiconductors
;
Silver*
;
Tears
;
Visual Acuity*
5.The Trial of Continuous Intravenous Infusion of Ketamine in Patients with Phantom Limb Pain: A case report.
Yong Kwan CHEONG ; Cheol LEE ; Yong SON ; Yoon Kang SONG ; Tai Yo KIM ; Seung Woo LEE
The Korean Journal of Pain 2006;19(2):233-236
Phantom limb pain is a painful sensation from an absent limb. The onset of pain is generally early, with 75% of patients developing pain within the first few days after amputation. The frequency and duration of attacks tend to be reduced with time, although the prevalence and intensity remain constant. We report here a case of a 38-year-old man who exhibited the signs and symptoms of phantom limb pain due to the above-knee amputations of both legs. He was not responded to opioid therapy and a continuous intravenous infusion of ketamine, an N-methyl-D-aspatate receptor antagonist, reduced his severe pain.
Adult
;
Amputation
;
Extremities
;
Humans
;
Infusions, Intravenous*
;
Ketamine*
;
Leg
;
Phantom Limb*
;
Prevalence
;
Sensation
6.A Case of Meigs` Syndrome with Elevated Serum CA 125 Level.
Ji Young LEE ; Kwan Young OH ; Jin Hee SON ; Soo Youn KIM ; Seung Cheol KIM
Korean Journal of Gynecologic Oncology and Colposcopy 1998;9(3):316-319
Meigs' sydrome is a relatively uncommon and the unusual condition of ascites and fluid in the chest associated with benign and solid tumors of the ovary with the gross appearance of a fibroma. The mechanism of this syndrome is not completely understood, but various lymphatics through the diaphragm seem the likely route for ascitic fluid into the chest. We present a case of Meigs' syndrome associated with fibrothecoma and elevate CA 125 with the brief review of literature.
Ascites
;
Ascitic Fluid
;
Diaphragm
;
Female
;
Fibroma
;
Meigs Syndrome
;
Ovary
;
Thorax
7.Small Cell Carcinoma of the Ovary of Pulmonary Type: Immunohistochimical and Ultrastructural Study A Case Report.
Ji Young LEE ; Hyang Mee KIM ; Young Soo SON ; Soon Hee SUNG ; Woon Sup HAN ; Seung Cheol KIM
Korean Journal of Gynecologic Oncology and Colposcopy 1998;9(3):307-311
No abstract available.
Carcinoma, Small Cell*
;
Female
;
Ovary*
8.The Role of Clusterin in Apoptosis Induced by Testicular Torsion.
Eun Chan PARK ; Cheol KWAK ; Hwancheol SON ; Seung June OH ; Sang Eun LEE ; Hwang CHOI
Korean Journal of Urology 2004;45(4):380-389
PURPOSE: This study examined the histological changes and apoptosis in contralateral rat testes after testicular torsion or the repair of torsion, and investigated the functional role of clusterin in the pathogenesis for the injury of the contralateral testes after testicular torsion. MATERIALS AND METHODS: H&E staining and TUNEL assay were performed in contralateral testes following torsion or repair of torsion. The mean numbers of spermatids per tubule and apoptotic germ cells per tubule were calculated in each group with respect to time. The expression of clusterin after torsion or the repair of torsion was observed by RT-PCR and Western blot analysis. RESULTS: Following the repair of torsion, significant germ cell injuries and abnormal spermatogenesis were observed in the contralateral testes compared to those without repair. The expressions of clusterin mRNA and protein after testicular torsion were no different from those in the control testes. However, in the contralateral testes, the clusterin mRNA and clusterin protein expressions in the contralateral testes were increased 8 hours after the repair of torsion. The appearance of apoptosis in the contralateral testes after the repair of torsion appeared to correlate with the clusterin protein expression. CONCLUSIONS: The injury to contralateral testes during testicular torsion seems to be caused by the apoptosis induced by reperfusion of ischemic torsioned testis. Clusterin appears to play an antiapoptotic role in the apoptotic process in the injury to the contralateral testis due to the repair of testicular torsion.
Animals
;
Apoptosis*
;
Blotting, Western
;
Clusterin*
;
Germ Cells
;
In Situ Nick-End Labeling
;
Rats
;
Reperfusion
;
RNA, Messenger
;
Spermatic Cord Torsion*
;
Spermatids
;
Spermatogenesis
;
Testis
9.Esophagus, Stomach & Intestine; Primary Duodenal Cancer Associated with Early Gastric Cancer: A Case of Double Primary Cancer.
Jong Chul RHEE ; Kwang Cheol KOH ; Poong Lyul RHEE ; Jae Jun KIM ; Seung Woon PAIK ; Hee Jung SON ; Mi Kyung KIM
Korean Journal of Gastrointestinal Endoscopy 1997;17(2):181-186
A case of resected primary duodenal cancer associated with early gastric cancer is reported. A 67-year-old male complaining of nausea and vomiting was admitted. Endo-scopic examination showed an ulcerative lesion withblood clot in the angle of the stomach and stricture in the duodenum. The stomach lesion was proven to be signet ring cell carcinoma by biopsy. Exploratory laparotomy was done and frozen specimen of duodenum was revealed to be malignant. Subtotal gastrectomy and pancreaticoduodenectomy with lymph node dissection were done and the specimen from stricture of duodenum was proven to be adenocarcinoma. The gastric cancer was limited to the mucosa and metastasis was not recognized in regional lymph node, Furthermore, there was normal mucosa between gastric cancer and duodenal cancer. Therefore, cancers in the stomach and duodenum were considered to be a case of double prim~iary cancer.
Adenocarcinoma
;
Aged
;
Biopsy
;
Carcinoma, Signet Ring Cell
;
Constriction, Pathologic
;
Duodenal Neoplasms*
;
Duodenum
;
Esophagus*
;
Gastrectomy
;
Humans
;
Intestines*
;
Laparotomy
;
Lymph Node Excision
;
Lymph Nodes
;
Male
;
Mucous Membrane
;
Nausea
;
Neoplasm Metastasis
;
Pancreaticoduodenectomy
;
Stomach Neoplasms*
;
Stomach*
;
Ulcer
;
Vomiting
10.Results of Surgical Treatment and Analysis of Prognostic Factors in Primary Gastric Adenocarcinoma.
Cheol Hun CHUNG ; Young Jae MOK ; Gil Soo SON ; Seung Joo KIM ; Sae Min KIM
Journal of the Korean Cancer Association 1999;31(3):458-465
PURPOSE: Despite gsstric cancer is one of the most common ma1ignancies, its prognosis has not been improved significantly. Therefore, it is important to know what clinical and pathological factors relate to survival in gastric carcinoma in order to improve survival rate. The aim of this retrospective study was to evaluate treatment results and to analyze the factors that affect the survival of patients with gastric carcinoma. MATERIALS AND METHODS: A total of 1,580 patients with primary gastric adenocarcinoma who had been treated surgically during the period 1983-1996 at the Department of Surgery, Korea University College of Medicine was studied to evaluate the treatment outcome. Prognostic factors were investigated by univariate and multivariate analyses in 1,407 resected patients. RESULTS: The 5-year survival rate was 57.1% in all case, 62.4% in resected cases, and there was no survivor at 2.5 year in unresectable cases. In univariate analysis, gross type, maximum tumor diameter, depth of invasion, lymph node involvement, distant metastasis, histologic type and type of operation were found to correlate significantly with survival. Multivariate analysis indicated that lymph node involvement, depth of invasion and type of cancer were independently conelated with survival. The stage-related survival rates (UICC, 1987) were 95.8% (stage Ia), 87.6% (stage Ib), 76.7% (stage II), 51.3% (stage 1IIa), 25.5% (stage IIlb), 9.4% (stage IV) and the stage-related survival rates (UICC, 1997) 95.8% (stage Ia), 87.6% (stage Ib), 76.4% (stage II), 55.2% (stage IIla), 24.0% (stage IIIb), 13.4% (stage IV). There was no difference between two staging systems. CONCLUSIONS: These results suggest that lymph node involvement, depth of invasion, and gross type were the most important prognostic factors, indicating that they may be helpful as predictors of long-term survival and in planning the treatment.
Adenocarcinoma*
;
Humans
;
Korea
;
Lymph Nodes
;
Multivariate Analysis
;
Neoplasm Metastasis
;
Prognosis
;
Retrospective Studies
;
Survival Rate
;
Survivors
;
Treatment Outcome