We studied the change in intraocular pressure (IOP) in 15 consecutive cataract patients who underwent extracapsular cataract extraction and posterior chamber lens implantation between Feb. 1993 and Apr. 1993 to evaluate the effect of this surgery on postoperative IOP. To evaluate the clinical usefulness of non-contact tonometer, the intraocular pressures were measured with Kowa non-contact tonometer (TM-2000, Japan) as well as Goldmann applanation tonometer. There was a decrease in IOP of 3.4±2.9mmHg (p<0.001) 3 months after this surgery and the intraocular pressure differences between pseudophakic eyes and contralateral phakin eyes at 3 months postoperatively were 2.4±3.8mmHg (p<0.05). The correlation coefficient between non-contact tonometer and Goldmann tonometer was 0.8876 (p=0.001) in the postoperative 76 eyes. Therefore, out results suggest that extracapsular cataract extraction and posterior chamber lens implantation alone can be a useful surgical method in cataract patient with ocular hypertension, and non-contact tonometer was relatively accurate in measuring the postoperative intraocular pressure.
Cataract Extraction* ; Cataract* ; Humans ; Intraocular Pressure* ; Methods ; Ocular Hypertension

No abstract available.
Liver Abscess* ; Liver*

No abstract available.
Humans ; Stomach Neoplasms*

No abstract available.
Esophageal Atresia*

No abstract available.
Spinal Muscular Atrophies of Childhood*

No abstract available.
Hemolytic-Uremic Syndrome*

Mutation of the p53 tumor-suppressor gene in exons 4 through 9 was examined in 34 cases of primary advanced gastric cancer using PCR-SSCP (polymerase chain reaction-single strand conformation polymorphism) and the results were compared with p53 protein expression as determined by immunohistochemistry (IHC) using a monoclonal antibody(DO-1). p53 protein detected by IHC was observed in 14 cases (41.2%) and genotypic mutation detected by PCR-SSCP in exons 4-9 was observed in 13 cases (38.2%) One case showed an aberrant band on PCR-SSCP both in Exon 7 and Exon 8/9. p53 alteration detected by either IHC or PCR-SSCP was observed in 19 cases (55.9%), but only 8 cases (23.5%) showed both p53 mutation and protein expression. We also tried to obtain the correlation between relative intensity of the shifted bands on PCR-SSCP and percentage of positive cells by IHC, but a significant correlation was not seen between relative intensity of shifted bands on PCR-SSCP and positve cell ratio. A discrepancy between p53 protein expression and p53 mutation is observed in primary gastric carcinomas. The reason for this discrepancy are not apparent. However, examination of gastric carcinomas for mutations in other exons may identify a better correlation with protein overexpression. The results obtained in this study suggest that the negative reaction for p53 immunohistochemistry may not necessarily mean no genetic alteration of the p53 locus.
Exons ; Immunohistochemistry* ; Stomach Neoplasms

The Peutz-Jeghers syndrome is a familial disesse charaeterized by mucocutaneaus pigmentation, gastrointestinal polyposis, and transmission of autosomal dominant trait. This syndrome is clinically important becuase of the coreplieation caused by the polyp, leading to abdominal pain, gastrointestinal bleeding, and intussusception. Authors experienced a case of Peutz-Jeghers syndrome admitted to Walace Memorial Baptist Hospital who was complained of recurrent abdominal pain, melanin pigmentation of lips, oral mucosa, and digits. UGI series, small bowel series, colon cnema, gastrofiberscopy, and colonoseopy revealed multiyle intestinal polyps. Pathologic findings on endoseopic polypectomy showed hamartomatous polyp.
Abdominal Pain ; Colon ; Hemorrhage ; Intestinal Polyps ; Intussusception* ; Lip ; Melanins ; Mouth Mucosa ; Peutz-Jeghers Syndrome ; Pigmentation ; Polyps ; Protestantism

No abstract available.

PURPOSE: Young age is controversial risk factor for filtration failure following trabeculectomy with adjunctive mitomycin C (MMC). This study aimed at investigating whether juvenile-onset primary open angle glaucoma (JPOAG) patients have worse long-term outcome than adult-onset primary open angle glaucom (APOAG) patients following primary trabeculectomy with adjunctive MMC. METHODS: Medical records of 162 eyes of 113 primary open angle glaucoma patients who had undergone primary trabeculectomy with MMC and minimum follow up of 12 months were retrospectively reviewed. All the patients were free of other known risk factors except young age for surgical failure following trabeculectomy. The patients were divided into two groups; juvenile group (68 eyes of 42 patients, 10~35 years of age) and adult group (51 eyes of 41 patients, age 50 years or older). Forty-three eyes of 30 patients, aged 36~49 years, were excluded from the analysis for the study purpose. Demographic, preoperative and postoperative data were collected for up to 96 months. Kaplan-Meier survival analysis was used for probability of cumulative success estimations according to success criterion (defined as postoperative intraocular pressure of 20 mmHg or less without glaucoma medications). RESULTS: Cumulative life-table success rates of juvenile group were 98.5% at 12 months, 84.6% at 48 months, and 71.2% at 96 months. Those of adult group were 98.0%, 77.0%, and 68.5% respectively. There was no statistically significant difference in overall filtration success rates between juvenile and adult groups (p=0.52). Using a Cox proportional hazard regression analysis of potential risk factors, young age was not found to significantly affect the surgical failure (p=0.97). CONCLUSIONS: Young age itself was not associated with the poor surgical outcome following primary trabeculectomy with adjunctive MMC in this study. The present results suggest that the success rate of the JPOAG compares favorably with that of the APOAG. Primary trabeculectomy with MMC in juvenile glaucoma without other concomitant risk factors may have a favorable long-term clinical outcome as adult glaucoma.
Adult ; Filtration ; Follow-Up Studies ; Glaucoma ; Glaucoma, Open-Angle* ; Humans ; Intraocular Pressure ; Medical Records ; Mitomycin* ; Retrospective Studies ; Risk Factors ; Trabeculectomy*