No abstract available.
Korea*

The new president was elected unusually within short period, because of the president's impeachment. As the result, policy window as the president's election was rarely opened in healthcare sector. The new government has to overcome the era of aged society, low birth rate, and low economic growth rate and to prepare the unification of nation. The new government should set the priority of healthcare policies through a holistic and systematic approach. And the new government must implement a balanced healthcare policy with equity and efficiency, regulation and support, consumers and suppliers, in-kind benefits and cash benefits, and so on.
Birth Rate ; Delivery of Health Care ; Economic Development ; Health Care Sector ; Health Policy*

No abstract available.
Aging* ; Humans ; Male* ; Reproduction*

No abstract available.
Aging* ; Humans ; Male* ; Reproduction*

No abstract available.
Anxiety* ; Depression* ; Humans ; Inpatients* ; Schizophrenia*

OBJECTIVE: To assess the scavenging effect of carnitine derivatives on oxidative damage to sperm during sperm processing cryopreservation and thawing. MATERIALS AND METHODS: Fresh semen samples from 20 normal healthy volunteers were collected by masturbation after at least 48 hours abstinence. After liquefaction of semen samples at room temperature, the specimens were diluted with sperm wash media (Ham's F-10, Life technologics) to a uniform density of 20x106/ml. L-carnitine or acetylcarnitine were added with various concentration of 0 micrometer, 10 micrometer, 30 micrometer in semen sample or cryoprotectant. All specimens were cryopreservated at -196degrees C LN2 for 3 days. Sperm motility, vitality, fertilizing capacity, reactive oxygen species formation and the level of lipid peroxidation were analyzed by computer assisted semen analyzer, eosin-nigrosin stain, hypo-osmotic swelling test, chemiluminescence and thiobarbituric acid method, respectively, during sperm processing, cryopreservation and thawing. RESULTS: The sperm motility was only increased in proportion to the concentration of acetylcarnitine with no statistical significance (p>0.05). The sperm vitality was also significantly improved in proportion to the concentration of acetylcarnitine with statistical significance (p<0.05). The sperm fertilizing capacity was significantly increased in proportion to the concentration of L-carnitine and acetylcarnitine and reactive oxygen species generation and lipid peroxidation were significantly decreased with same fashion(p<0.05). On comparison of effects between L-carnitine and acetylcarnitine, acetylcarnitine was superior to L-carnitine on the improvement of sperm motility and vitality as well as the suppression of reactive oxygen species generation and lipid peroxidation. CONCLUSION: These results suggest that carnitine derivatives have a scavenging effect against oxidative damages during sperm processing, cryopreservation and thawing. Therefore, carnitine derivatives may be useful as an oral antioxidant in patients with male infertility due to increased ROS generation.
Acetylcarnitine* ; Carnitine* ; Cryopreservation ; Healthy Volunteers ; Humans ; Infertility, Male ; Lipid Peroxidation ; Luminescence ; Male ; Masturbation ; Reactive Oxygen Species ; Semen ; Sperm Motility ; Spermatozoa*

No abstract available.
Disasters*

OBJECTIVE: The effects on spermatogenesis by expression of vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) were investigated. MATERIALS AND METHODS: Testicular specimens were obtained from 40 infertile males due to primary testicular failure and from 10 fertile males with other urologic problems. The specimens of infertile males were devided into 4 groups according to histologic findings; Sertoli cell only syndrome (A), maturation arrest (B), hypospermatogenesis (C) and sloughing and disorganization (D). VEGF and ET-1 expression were detected with immunohistochemical stain. RESULTS: VEGF expression on Leydig cell was detected in all cases. But, VEGF expression rates on germ cell were significantly higher in infertile group B, C, D compared to that of the control group (p<0.05). ET-1 expression rates on Leydig cell was significantly lower in all infertile group compared to that of the control group (p<0.05). But, ET-1 expression rates on Sertoli cell was significantly higher in all infertile group compared to that of the control group (p>0.05). In germ cell of infertile group, LH, FSH and prolactin were significantly decreased, and estradiol is increased in positive stain group on ET-1 immunohistochemical stain (p<0.05). VEGF and ET-1 expression were not correlated mean seminiferous tubule diameter (p>0.05). CONCLUSIONS: Abnormal spermatogenesis would be reflected in VEGF expression in germ cell.
Endothelin-1* ; Estradiol ; Germ Cells ; Humans ; Male ; Oligospermia ; Prolactin ; Seminiferous Tubules ; Sertoli Cell-Only Syndrome ; Spermatogenesis ; Testis* ; Vascular Endothelial Growth Factor A

BACKGROUND: The paired vestibular end organs lie within the semicircular canal of the inner ear in the temporal bones. It plays a role on the control of posture through the vestibuloocular reflex and the vestibulo-spinal reflex. Motion sickness-like symptoms induced by the abnormal stimulation of the vestibular system suggested that the vestibular system participate in the autonomic nervous function. The present study was carried out to determine the role of the vestibular system on the control of blood pressure by way of the autonomic nervous system. METHODS: Blood pressure was measured by means of pressure transducer during stimulation of the vestibular system or following bilateral labyrinthectomies in Sprague-Dawley rats weighing from 200 to 300g. RESULTS: 1) Blood pressure was elevated by electrical stimulation of the vestibular nerve. 2) Also, the pressure was elevated when the vestibular system was excited or inhibited by rotatory stimulation or galvanic stimulation. 3) The pattern of elevation in blood pressure which induced by electrical stimulation of the vestibular nucleus showed a dynamic response at stimulation frequency of 200Hz and a static response at 50Hz. 4) Elevation of blood pressure induced by vestibular sitmulation was more inhibited following bilateral cervical sympathectomies than following bilateral vagotomies. 5) Decreasing the blood pressure induced by positional change of the body was reinforced following bilateral labyrinthectomies. CONCLUSION: These results suggest that the vestibular system plays a role on the control of blood pressure by way of the autonomic nervous system as well as on the control of posture, therefore, the vestibular system prevents blood pressure from decreasing by positional change of the body.
Animals ; Autonomic Nervous System ; Blood Pressure* ; Ear, Inner ; Electric Stimulation ; Posture ; Rats* ; Rats, Sprague-Dawley ; Reflex ; Reflex, Vestibulo-Ocular ; Semicircular Canals ; Sympathectomy ; Temporal Bone ; Transducers, Pressure ; Vagotomy ; Vestibular Nerve

The clinicopathological study was performed on 80 patients with urinary bladder tumor between 1973 and 1983. The histopathological survey was carried out using preserved tumor specimen slide on the retrospective fashion, that included the growth pattern and vessel invasion. The results were as follows : 1. The tumor histology were papillary and nonpapillary in 70 %, and 30 %, respectively in growth pattern and 74 transitional cell carcinoma(TCC), 3 squamous cell carcinoma(SCC), 2 adenocarcinoma (AC) and 1 mucoepithermoid carcinoma in cell type. 2. The Fade of TCC, Go, G1. G2 and G3 were 1.4%, 36.5%, 39.2% and 22.9% respectively, and the stage of those, in which superficial tumors(pTis-pT1) and invasive tumors( pT2-pT4) were 57.0% and 30.8% respectively. The histopathological mode of local spread was to have strands, nests and individual cells in about one sixth, lymphatic invasion in about one third and venous invasion in about one fifth. 3. The intramural hispathological mode of local spread (INF alpha,beta, and alpha), lymphatic invasion ( lyo, 1 and 2) and venous invasion were highly significant with respect to the hispathological grade and stage, and also within mutual relationship on the other hand.
Adenocarcinoma ; Hand ; Humans ; Retrospective Studies ; Urinary Bladder Neoplasms ; Urinary Bladder*