No abstract available.
Foot* ; Hand*

Paget's disease of bone (osteitis deformans), a chronic osseous disease of unknown etiology, is extremely rarein Asia although well known in western countries. This disease is characterized by the simultaneous absorption ofbone and the new bone formation of abnormal character affecting middle and later age groups. The authorsexperienced a case of monostotic Paget's disease involving left pelvic bone in 56-years old female. To ourknowledge, this is the first cas report of monostotic Paget's in Korea.
Absorption ; Asia ; Female ; Humans ; Korea ; Osteitis Deformans ; Osteogenesis ; Pelvic Bones

No abstract available.
Child* ; Hepatitis, Chronic* ; Humans ; Interferon-alpha*

Infective endocarditis is a disease that is characterized by the vegetations. Although cardiac complications remain the leading cause of death, endocarditis is complex, systemic illness with involvement of virtually all the organs. The spectrum and incidence of cardiovasular, neurologic, renal complications also are presented by direct embolism and immune- mediated phenomena. Systemic embolism is the common and serious complications associated with infective endocarditis. Mycotic aneurysm by septic embolization is known complication of bacterial endocarditis, but mycotic aneurysm of superior mesenteric artery is very rare complication and approximately 10 cases has been reported in the literature. Acute hemorrhagic pericarditis is unusual clinical manifestation of bacterial endocarditis and subject to catastrophic hemodynamic compromise secondary to cardiac tamponade. We report a case of bacterial endocarditis in 23 years old male who developed acute hemorrhagic pericarditis and hemoperitoneum due to rupture of mycotic aneurysm in superior mesenteric artery with brief review of lieratures.
Aneurysm, Infected* ; Cardiac Tamponade ; Cause of Death ; Embolism ; Endocarditis ; Endocarditis, Bacterial* ; Hemodynamics ; Hemoperitoneum* ; Humans ; Incidence ; Male ; Mesenteric Artery, Superior* ; Pericarditis* ; Rupture* ; Young Adult

OBJECTIVES: In HFRS, there is a varying degree of disseminated intravascular coagulation which was evident in the early phase of the illness. It is believed also that DIC would be the consequence, at least in part, of functional changes of endothelium resulting in kinin activation and clinical syndrome. This study investigated the role of adhesion molecule in the pathogenesis of Hantaan virus-related disease. METHODS: The expression of ICAM-1 antigen on the cell membrane of human umbilical vein endothelial cells was assessed by immunohistochemistry, and ICAM-1 mRNA in the endothelial cells was assessed by in situ hybridization after Hantaan virus infection (2.6 x 10(4) PFU/mL) with the time course. RESULTS: In immunohistochemistry, the number of ICAM-1 positive cells increased with time during the 12 or 24 hours after infection. 5 to 10% of HUVECs had been positive after 12-24 hours and the number of positive cells decreased abruptly after 24 hours. Hantaan antigen had been noticed after 12 hours focally on the HUVECs but continued to proliferate into day 7 post-infection when most of HUVECs were infected by Hantaan virus. In situ hybridization showed identical patterns of ICAM-1 mRNA expression after Hantaan virus infection. CONCLUSION: It implies that the Hantaan virus infection on HUVECs would express more ICAM-1 on their surface and implicated in the pathogenesis of early clinical syndrome of HFRS.
Cell Line ; Endothelium, Vascular/virology ; Endothelium, Vascular/immunology ; Gene Expression ; Hantaan Virus/pathogenicity* ; Hemorrhagic Fever with Renal Syndrome/immunology* ; Hemorrhagic Fever with Renal Syndrome/genetics ; Hemorrhagic Fever with Renal Syndrome/etiology ; Human ; Immunohistochemistry ; In Situ Hybridization ; Intercellular Adhesion Molecule-1/metabolism* ; Intercellular Adhesion Molecule-1/genetics* ; RNA, Messenger/metabolism ; RNA, Messenger/genetics

Permanent vascular access is a prerequisite for successful treatment of patients with chronic hemodialysis. Although a number of strategies including native and synthetic arterio-venous fistulae are performed to create vascular access, they are often not available due to peripheral vascular diseases which are common in patients with diabetes and elderly patients. So, in spite of technical advance, vascular access for hemodialysis remains a significant problem confronting the nephrologists. Recently, Permcath(R) (double lumen silicone rubber catheter) has been introduced and can provide temporary access in patients whose native fistulas have not yet matured and permanent access in patients who have difficulty in creating a arterio-venous fistula. We investigated the availability and the clinical outcome of use of Permcath(R) as temporary or permanent vascular access. Total 16 catheters were placed in 14 patients who were admitted in Chung-Ang University Hospital between April, 1993 to March, 1996. Clinical course of the patients and outcome of the catheters were observed, retrospectively. The mean age of the 14 patients was 56 9 (39-67) years. The indications were exhausted peripheral access, poor vascular system for conventional access operation, and limited life expectancy. The median survival of the catheters was 80 weeks with a range of one week to 113 weeks. The one-year actuarial catheter survival rate was 67% and 44% at 2 year. The most common complication during use of Permcath(R) was infection, occurred in 5 patients (31.2%). The 5 catheters were removed because of complications of catheter such as infection or malfunction. We suggest that the Permcath(R) is a safe and durable temporary vascular access for patients with poor vascular system anticipating a long duration for arterio-venous fistula maturation and permanent access for patients who have exhausted peripheral access sites.
Aged ; Catheters ; Fistula ; Humans ; Life Expectancy ; Peripheral Vascular Diseases ; Renal Dialysis ; Retrospective Studies ; Silicone Elastomers ; Survival Rate

PURPOSE: As the lay public indirectly acquires medical knowledge through the mass media, it is desirable to show medically correct care in movies or TV dramas. We evaluated whether the emergency care depicted in Korean boxoffice movies is appropriate and medically sound. METHODS: We selected Korean movies which more than 100,000 peoples had seen in Seoul from 1996 to 2001. We excluded fantasy or historical movies from the list. After searching the emergency situations in videos, including cardiopulmonary arrest, loss of consciousness, injuries, and medical emergencies, we evaluated whether the needed care was provided and properly done and whether the result was medically sound. RESULTS: During the 6-year period, we found 46 emergency situations in 80 movies (0.6 per movie). Loss of consciousness was the most common emergency situation (34.8%), followed by cardiopulmonary arrest (15.7%). Emergency care was provided in 24 situations (52.2%), but was appropriate in only 8 among those 24 situations. Regardless of care, 50% improved and another 36.4% improved without any interventions. There was total of 106 necessary actions in the 46 situations: for instance, EMS system activation, airway maintenance, breathing and circulation support, spinal cord protection, and hemostasis. Only 21 among the 106 necessary actions (19.8%) were done. Hemostasis by external compression was the most common action done (44.4%), and airway maintenance was the least (3.6%). CONCLUSION: We found that emergency care and its result were not properly depicted in Korean box-office movies. Emergency physicians and the medical community should pay attention to this problem and serve as medical advisors to guarantee a medically sound portrayal.
Drama ; Emergencies* ; Emergency Medical Services* ; Emergency Treatment ; Fantasy ; Heart Arrest ; Hemostasis ; Mass Media ; Respiration ; Seoul ; Spinal Cord ; Unconsciousness

No abstract available.

The authors tried to evaluate the effect of the growth factors on cell proliferation in the human retina astrocyte culture. Each growth factor, EGF, bFGF, GGF, IGF-1 or PDGF, together with BrdU was added to astrocytes-enriched cultures in the serum-free media. The proliferating effect of each growth factor was evaluated by a double immunofluo- rescenece labelling for GFAP and BrdU. By and addition of each growth factor, the number of retinal astrocytes at the synthetic stage significantly increased than those of control group (p<0.01). In comparision, PDGF was more potent than IGF-1 (p<0.01). Above data extended the concept of astrocytic proliferation caused by several growth factors in human retinal injury.
Astrocytes ; Bromodeoxyuridine ; Cell Proliferation ; Culture Media, Serum-Free ; Epidermal Growth Factor ; Humans ; Insulin-Like Growth Factor I ; Intercellular Signaling Peptides and Proteins* ; Neuroglia* ; Retina ; Retinaldehyde*

Since the anatomy of vocal fold and physiology of phonation are introduced, many surgical techniques for vocal fold disorders has advanced. Microflap and mini-microflap surgery were designed to protect the bare surface of the operated site. However, many new techniques have been based on common sense because of the absence of an accessible animal model with a vocal ligament. Therefore, authors studied to evaluate the differences of the results between mini-microflap surgery and microdissection surgery. Thirty-four mini-microflap surgeries(17 bilateral) and twenty-eight microdissection surgeries(14 bilateral) were performed on 31 patients. Patients' subjective evaluation and videostrobolaryngoscopic examination revealed that mini-microflap surgery was better than microdissection surgery. A mini-microflap surgery, as does limited mucosal resection, was more efficacious in the treatment of vocal nodules than microdissection surgery.
Humans ; Microdissection* ; Models, Animal ; Phonation ; Physiology ; Vocal Cords