Anti-Bacterial Agents ; administration & dosage ; adverse effects ; blood ; Bacteremia ; drug therapy ; Body Weight ; Drug Dosage Calculations ; Female ; Gentamicins ; administration & dosage ; adverse effects ; blood ; Gestational Age ; Humans ; Infant, Newborn ; Injections, Intramuscular ; Male

INTRODUCTIONThis study aims to compare and assess usefulness of day 3 and 4 (49 to 96 hours) pre-phototherapy total serum bilirubin (TSB) in predicting subsequent significant hyperbilirubinaemia (SHB) in glucose-6-phosphate dehydrogenase (G6PD) deficient neonates.

MATERIALS AND METHODSThis prospective study was on all the G6PD deficient newborns weighing >2500 g. Day 3 and 4 pre-phototherapy TSB and phototherapy requirements in their first 2 weeks of life were analysed for its value in predicting subsequent SHB.

RESULTSThe frequency of G6PD deficiency was 2.4%, 1 per 42 live births (1.3% in males and 1.1% in females). Phototherapy was required in 51% of G6PD deficient infants, all within the first week of life. In the absence of SHB in the first week, the probability of its development in the second week was zero (95% confidence interval, 0 to 0.051). The day 4 pre-phototherapy TSB of <160 micromol/L predicted no measurable risk of subsequent SHB (sensitivity, 94%; 95% confidence interval, 83.5% to 97.9%; specificity 82.8%; 95% confidence interval, 71.1% to 90.4%).

CONCLUSIONSG6PD deficient newborns without SHB in their first week of life were at no measurable risk of its development in the second week. Day 4 pre-phototherapy has better sensitivity and specificity compared to day 3 pre-phototherapy TSB in predicting the risk of subsequent SHB. Low-risk infants, thus identified, may be eligible for discharge on or before day 7 of life. Infants with Day 4 TSB <160 can be even discharge on day 4 with follow-up appointment. Evidence-based early discharge can decrease the social, emotional and financial burden of G6PD deficiency in Singapore.

Bilirubin ; blood ; Female ; Glucosephosphate Dehydrogenase ; Glucosephosphate Dehydrogenase Deficiency ; diagnosis ; economics ; psychology ; Humans ; Hyperbilirubinemia, Neonatal ; diagnosis ; etiology ; prevention & control ; Infant, Newborn ; Jaundice, Neonatal ; Male ; Patient Discharge ; Phototherapy ; Prognosis ; Prospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome

INTRODUCTIONIntravenous lipid is commonly used as part of total parenteral nutrition (TPN) in premature babies. The gold standard of measuring lipid tolerance involves measuring serum triglyceride levels. Many hospitals in Asia do not have this facility and rely on visual turbidity to titrate the rate of lipid infusion. The aim of this study was to determine if visual turbidity correlates with serum triglyceride levels.

MATERIALS AND METHODSTwenty-seven samples were taken from 8 babies on intravenous (IV) lipid infusion for the analysis of serum triglyceride levels and visual turbidity (assessed by 2 senior neonatologists independently). Serum turbidity was classified either as clear or turbid. Lipid intolerance was defined as triglyceride levels greater than 200 mg/dL (2.25 mmol/L).

RESULTSBoth neonatologists similarly classified 20 out of 27 specimens. Serum triglyceride levels for clear samples (n = 10) were significantly lower than those for turbid samples (n = 10) (P <0.01). The clear specimens all had normal serum triglyceride levels (mean, 1.16 mmol/L; range, 0.43 to 1.96). Not all turbid specimens had unacceptable serum triglyceride levels (mean, 2.37 mmol/L; range, 1.37 to 5.75). In the remaining 7 specimens, there was a difference in opinion regarding serum turbidity. The triglyceride levels for these 7 samples were all normal (mean, 1.17 mmol/L; range, 0.66 to 1.72).

CONCLUSIONSerum turbidity may be used as a screening tool in assessing lipid tolerance in babies on TPN as all clear samples had acceptable serum triglyceride level if we set the maximum cutoff at 2.25 mmol/L. Patients with turbid samples should ideally have their serum triglyceride taken to confirm lipid intolerance before altering their lipid infusion rate as they may have acceptable triglyceride levels.

Drug Combinations ; Fat Emulsions, Intravenous ; administration & dosage ; therapeutic use ; Gestational Age ; Humans ; Hyperlipidemias ; blood ; prevention & control ; Infant, Newborn ; Infant, Premature ; blood ; Nephelometry and Turbidimetry ; Parenteral Nutrition, Total ; methods ; Phospholipids ; administration & dosage ; therapeutic use ; Prognosis ; Sorbitol ; administration & dosage ; therapeutic use ; Triglycerides ; blood

INTRODUCTIONNeurodevelopmental outcome of borderline viability neonates have lagged behind improvement in survival figures. Accurate figures based on local outcome allow us to better counsel parents and to prognosticate with greater accuracy on both short- and longterm outcomes.

MATERIALS AND METHODSA retrospective cohort study of 101 consecutively born neonates, born from 21 to 26 weeks gestation over an 11-year period from 1 January 1994 to 31 December 2005 was conducted. Long-term outcomes were assessed at 2, 5 and 8 years of age in terms of mental developmental index (MDI) or intelligence quotient (IQ) scores, hearing and visual impairments, handicaps and impairments, school placement and interventions required.

RESULTSSurvival rates were 20.0%, 60.9%, 70.4% and 73.2% for neonates born at 21 to 23, 24, 25 and 26 weeks gestation respectively. Factors that predicted increased mortality included higher alveolar-arterial oxygen difference (AaDO2) with odds ratio (OR) 1.005 and lower birth weight OR 0.993. Rates of severe retinopathy of prematurity (ROP) (stage 3 or worse) were 100%, 57.1%, 42.1% and 26.7% for 21 to 23, 24, 25 and 26 weeks gestation respectively. Rates of bronchopulmonary dysplasia (BPD) were 100.0%, 57.1%, 63.2% and 60.0% respectively. Rates of severe intraventricular haemorrhage (IVH) were 0%, 7.1%, 5.3% and 10.0% respectively. Moderate to severe disability rates at 2 years old were 100%, 44.4%, 33.3% and 30.4% respectively. At 5 years old, moderate to severe disability rates were 16.7%, 22.2% and 14.3% respectively for those born at 24, 25 and 26 weeks gestation. Interpretation at 8 years was limited by small numbers.

CONCLUSIONOur results indicated that local figures for mortality and morbidity remained high at the limits of viability, although they were comparable to outcomes for large scale studies in advanced countries.

Cerebral Palsy ; diagnosis ; epidemiology ; therapy ; Child ; Child, Preschool ; Developmental Disabilities ; diagnosis ; epidemiology ; therapy ; Epilepsy ; diagnosis ; epidemiology ; therapy ; Female ; Follow-Up Studies ; Hearing Loss ; diagnosis ; epidemiology ; therapy ; Humans ; Infant, Extremely Premature ; Infant, Newborn ; Infant, Premature, Diseases ; diagnosis ; epidemiology ; mortality ; therapy ; Infant, Very Low Birth Weight ; Intellectual Disability ; diagnosis ; epidemiology ; therapy ; Logistic Models ; Male ; Outcome Assessment (Health Care) ; Psychological Tests ; Retrospective Studies ; Singapore ; epidemiology ; Vision Disorders ; diagnosis ; epidemiology ; therapy

COVID-19/therapy* ; Equipment and Supplies ; Female ; Humans ; Infant, Newborn ; N95 Respirators ; Patient Isolators ; Personal Protective Equipment ; Practice Guidelines as Topic ; Pregnancy ; Pregnancy Complications, Infectious ; Respiratory Protective Devices ; Resuscitation/methods* ; SARS-CoV-2 ; Singapore

INTRODUCTIONExternal ear abnormalities accompany many syndromes and genetic conditions. Yet, there are currently limited Asian references and no local norms for ear measurements and definitions for "low-set ears". The authors therefore describe ear measurements in a Singapore newborn population and seek to establish the applicability of the general accepted definition of "low-set ears" being that of "less than a third of the entire ear height being above the inter-medial canthal line".

MATERIALS AND METHODSBabies managed by the Department of Neonatal and Developmental Medicine during a 3-week period were measured by 2 investigators using the Feingold and Bossert technique. Intra- and inter-rater reliabilities were calculated. The influence of various anthropometric factors on and their relationships with ear length (EL) and width (EW) was analysed.

RESULTSA total of 104 neonates (20% preterm at birth) were included in this study. Median gestation was 38 weeks (range, 32 to 42). Mean birth weight was 2910 +/- 657 g. Mean EW and EL for term infants were 2.1 +/- 0.1 cm and 3.6 +/- 0.3 cm respectively, without significant differences for different-sided ears, investigators, race or gender. Mean percentage of right and left ear above the denoted line was 52 +/- 9% and 47 +/- 10% respectively (P = 0.000), with 3rd percentile being 33%.

CONCLUSIONSSingaporean neonatal ears are comparable with other Asian neonates - larger than Hong Kong Chinese babies, though similar to Japanese newborns - but smaller than Caucasian neonates. The definition of "low-set ears" is consistent with the general accepted definition.

Anthropometry ; Ear Auricle ; anatomy & histology ; Ethnic Groups ; Female ; Humans ; Infant, Newborn ; Male ; Reference Values ; Singapore

INTRODUCTIONBoth gestation and birth weight have significant impact on mortality and morbidity in newborn infants. Nomograms at birth allow classification of infants into small for gestational age (SGA) and large for gestational age (LGA) categories, for risk stratification and more intensive monitoring. To date, the growth charts for preterm newborn infants in Singapore are based on the Fenton growth charts, which are constructed based on combining data from various Western growth cohorts. Hence, we aim to create Singapore nomograms for birth weight, length and head circumference at birth, which would reflect the norms and challenges faced by local infants.

MATERIALS AND METHODSGrowth parameters of all babies born or admitted to our unit from 2001 to 2012 were retrieved. Following exclusion of outliers, nomograms for 3 percentiles of 10th, 50th, and 90th were generated for the gestational age (GA) ranges of 25 to 42 weeks using quantile regression (QR) combined with the use of restricted cubic splines. Various polynomial models (second to third degrees) were investigated for suitability of fit. The optimum QR model was found to be a third degree polynomial with a single knotted cubic spline in the mid-point of the GA range, at 33.5 weeks. Check for goodness of fit was done by visual inspection first. Next, check was performed to ensure the correct proportion: 10% of all cases fall above the upper 90th percentile and 10% fall below the lower 10th percentile. Furthermore, an alternative formula-based method of nomogram construction, using mean, standard deviation (SD) and assumption of normality at each gestational age, was used for counterchecking.

RESULTSA total of 13,403 newborns were included in the analysis. The new infant-foetal growth charts with respect to birth weight, heel-crown length and occipitofrontal circumference from 25 to 42 weeks gestations with the 10th, 50th and 90th were presented.

CONCLUSIONNomograms for birth weight, length and head circumference at birth had significant impact on neonatal practice and validation of the Singapore birth nomograms against Fenton growth charts showed better sensitivity and comparable specificity, positive and negative predictive values.

Birth Weight ; Body Height ; Cephalometry ; Child ; Cohort Studies ; Female ; Gestational Age ; Growth Charts ; Humans ; Infant, Newborn ; Male ; Nomograms ; Reference Values ; Singapore

INTRODUCTIONChildhood developmental and behavioural disorders (CDABD) have been increasingly recognised in recent years. This study evaluated the profiles and outcomes of children referred for developmental and behavioural concerns to a tertiary child developmental centre in Singapore. This is the first such regional database.

METHODSBaseline information, obtained through a questionnaire, together with history at first consultation, provided information for referral, demographic and presentation profiles. Clinical formulations were then made. Definitive developmental and medical diagnoses, as well as outcomes based on clinical assessment and standardised testing, were recorded at one year post first consultation.

RESULTSOut of 1,304 referrals between January 1, 2003 and December 1, 2004, 45% were 2-4 years old and 74% were boys. The waiting time from referral to first consultation exceeded four months in 52% of children. Following clinical evaluation, 7% were found to be developmentally appropriate. The single most common presenting concern was speech and language (S&L) delay (29%). The most common clinical developmental diagnosis was autism spectrum disorder (ASD) (30%), followed by isolated S&L disorder, global developmental delay (GDD) and cognitive impairment (CI). Recommendations included S&L therapy (57%), occupational therapy (50%) and psychological/behavioural services (40%). At one year, ASD remained the most common definitive developmental diagnosis (31%), followed by S&L disorder, CI and GDD. Most were children with high-prevalence, low-moderate severity disorders who could potentially achieve fair-good prognosis with early intervention.

CONCLUSIONBetter appreciation of the profile and outcome of children with CDABD in Singapore could enable better resource planning for diagnosis and intervention.

Adolescent ; Adult ; Child ; Child Behavior Disorders ; diagnosis ; epidemiology ; Child Development Disorders, Pervasive ; epidemiology ; therapy ; Child, Preschool ; Databases, Factual ; Developmental Disabilities ; diagnosis ; epidemiology ; Female ; Humans ; Infant ; Male ; Occupational Therapy ; Psychotherapy ; Registries ; Singapore ; Speech Disorders ; epidemiology ; therapy ; Speech Therapy ; Surveys and Questionnaires ; Time Factors ; Treatment Outcome

We present the revised Neonatal Resuscitation Guidelines for Singapore. The 2015 International Liaison Committee on Resuscitation Neonatal Task Force's consensus on science and treatment recommendations (2015), and guidelines from the American Heart Association and European Resuscitation Council were debated and discussed. The final recommendations of the National Resuscitation Council, Singapore, were derived after the task force had carefully reviewed the current available evidence in the literature and addressed their relevance to local clinical practice.

In this paper, we provide guidance to clinicians who care for infants born to mothers with suspected/confirmed COVID-19 during this current pandemic. We reviewed available literature and international guidelines based on the following themes: delivery room management; infection control and prevention strategies; neonatal severe acute respiratory syndrome coronavirus 2 testing; breastfeeding and breastmilk feeding; rooming-in of mother-infant; respiratory support precautions; visiting procedures; de-isolation and discharge of infant; outpatient clinic attendance; transport of infant; and training of healthcare staff. This guidance for clinical care was proposed and contextualised for the local setting via consensus by members of this workgroup and was based on evidence available as of 31 July 2020, and may change as new evidence emerges.
Infant, Newborn ; Pregnancy ; Female ; Humans ; Mothers ; COVID-19/epidemiology* ; Singapore/epidemiology* ; COVID-19 Testing ; Pandemics/prevention & control* ; Infectious Disease Transmission, Vertical/prevention & control* ; Pregnancy Complications, Infectious/prevention & control*