Objective:To explore the relation of childhood trauma to marital satisfaction in divorce partici-pants and the mediating role of conflict resolution styles.Methods:Totally 305 divorced participants were selected by convenient sampling and evaluated with the Childhood Trauma Questionnaire(CTQ),the marital satisfaction subscale and the conflict resolution subscale of Olson Enrich Marital Inventory(ENRICH).Results:The detection rate of childhood trauma among the divorced participants was 67.5％.The CTQ scores were negatively correlated with the scores of conflict resolution styles and marital satisfaction(r=-0.14,-0.25,Ps＜0.05).The conflict resolution styles mediated entirely the relationship between childhood trauma and marital satisfaction in divorced participants,with a total effect of-0.06(95％CI:-0.11--0.01).Conclusion:It suggests that childhood trau-ma of divorcing participants may be associated with marital satisfaction and conflict resolution styles.

The fungus Xylaria sp. KYJ-15 was isolated from Illigera celebica. Based on the one strain many compounds (OSMAC) strategy, the strain was fermented on potato and rice solid media, respectively. As a result, two novel steroids, xylarsteroids A (1) and B (2), which are the first examples of C₂₈-steroid with an unusual β- and γ-lactone ring, respectively, along with two new dihydroisocoumarin glycosides, xylarglycosides A (3) and B (4), were identified. Their structures were elucidated by spectroscopic methods, X-ray diffraction and electronic circular dichroism (ECD) experiments. All isolated compounds were evaluated for cytotoxicity, DPPH radical scavenging activity, acetylcholinesterase inhibitory and antimicrobial effect. Compound 1 exhibited potent AChE inhibitory activity with an IC₅₀ value of 2.61 ± 0.05 μmol·L^-1. The β-lactone ring unit of 1 is critical for its AChE inhibitory activity. The finding was further confirmed through exploring the interaction of 1 with AChE by molecular docking. In addition, both compounds 1 and 2 exhibited obvious antibacterial activity against Bacillus subtilis with a minimum inhibitory concentration (MIC) of 2 μg·mL^-1. Compounds 3 and 4 exhibited antibacterial activities against Staphylococcus aureus with MICs of 4 and 2 μg·mL^-1, respectively, which also exhibited DPPH radical scavenging activity comparable to the positive control with IC₅₀ values of 9.2 ± 0.03 and 13.3 ± 0.01 μmol·L^-1, respectively.
Humans ; Acetylcholinesterase ; Molecular Docking Simulation ; Anti-Bacterial Agents ; Glycosides ; Lactones ; Pain