1.Study on Optimized Extraction of Fructus Schisandrae Chinensis
Xia LI ; Xiaobin JIA ; Yan CHEN ; Chenyi FAN
China Pharmacy 1991;0(06):-
OBJECTIVE: To optimize the extraction process of Fructus Schisandrae Chinensis. METHODS: Taking the contents of schizandrin, schisantherin A, deoxyschizandrin, r-schizandrin as the indexes, the influence on the extraction process by extract solvent and medicinal material particle diameter was examined, and the extraction parameters were optimized. RESULTS: Active components of Fructus Schisandrae Chinensis, after the medicinal material being crushed, can be effectively utilized through extracting by alcohol. The optimized extraction parameters were as follows: the medical material being ground into 40 meshes, extracted twice by 70% alcohol, 2 hours per time. CONCLUSION: The optimized extracting process works better than current technique adopted for formulated granule preparation, and can ensure quality to the highest degree.
2.Study on the Extraction and Purification Process of Schisandrin
Chenyi FAN ; Huihua WEI ; Yafang SHI ; Yan CHEN ; Xiaobin JIA
China Pharmacy 2001;0(12):-
OBJECTIVE: To optimize the process for extraction and purification of Schisandrin in Fructus Schisandra Chinensis. METHODS: The orthogonal test L9( 34) was adopted to optimize the water extraction process using Schisandrin and its extracts as indicators. The parallel test was used to optimize the parameters of the alcohol precipitation technique. RESULTS: The optimized process for extraction and purification of Schisandrin was as follows: extracting three times using 10- fold water, 1. 5h each time, with filter liquids concentrated to 1. 4g of crude drug mL- 1 then precipitated to 80% ; filtering alcohol liquids, and adjusting pH value to 7. CONCLUSIONS: This method can be used as a reference for the extraction of Fructus Schisandra Chinensis.
3.Extraction of Swertia chirayita(Roxb.ex Flemi) Karsten
Yiping HUANG ; Lili BI ; Chao CHEN ; Chenyi FAN ; Zhenzhen XU
Chinese Traditional Patent Medicine 1992;0(02):-
AIM:To determine the optimal extraction of effective component from Swertia chirayita(Roxb.ex Flemi) Karsten in Tibet. METHODS: HPLC method was used to determine the yield rate and mango glucoside content,the preference extract methods,extraction solvents and extraction method of Swertia chirayita(Roxb.ex Flemi) Karsten were chose by parallel comparative method. RESULTS: 75% ethanol was used to extract medicine materials by Percolate,the flow rate was 4 mL/min/kg,collecting 6 times liquor after percolate. CONCLUSION: The extraction method is simple and convenient,furthermore the extract stability is good too.
4.Absorption and metabolism of flavonoids in Herba Epimedii via rat intestinal perfusion model.
Yan CHEN ; Xiaobin JIA ; Xiaobin TAN ; Chenyi FAN ; Ming HU
China Journal of Chinese Materia Medica 2009;34(22):2928-2931
OBJECTIVETo study the absorption and metabolism of five flavonoids of Herba Epimedii (icariin, epimedin A, epi-medin B, epimedin C and baohuoside I) in rat intestine.
METHODUsing the rat intestinal perfusion model, the contents of the five flavonoids in perfusates were measured by HPLC and the permeability coefficients in different intestines were calculated.
RESULTThe permeabilities of five flavonoids in duodenum, jejunum, ileum, colon according to the sequence were as: icariin: 6.365, 5.349, 1.004, 0.601, epimedinA: 4.120, 3.397, 0.401, 0.257, epimedin B: 3.645, 3.135, 0.990 7, 0.434, epimedin C: 3.114, 2.882, 0.688, 0.470, baohuoside I: 2.324, 2.398, 1.529, 1.045, respectively. The analysis of the perfusates showed that icariin, epimedin A, epimedin B, epimedin C could be hydrolyzed in intestine. Icariin had two hydrolytic metabolites, whereas epimedin A, B, C only had one hydrolytic metabolite, respectively.
CONCLUSIONThe results indicated that the absorption of all the five flavonoids was significantly different in different intestinal segments, and the permeability in ileum and colon was significantly lower than that of the duodenum and jejunum. The metabolites of icariin, epimedin A, epimedin B, epimedin C were related with their structures and enzymes in intestine, and the metabolites were more in duodenum, jejunum, whereas were less in ileum and colon.
Absorption ; Animals ; Epimedium ; chemistry ; Flavonoids ; metabolism ; pharmacokinetics ; Intestines ; drug effects ; physiology ; Male ; Models, Animal ; Perfusion ; Plant Extracts ; metabolism ; pharmacokinetics ; Rats ; Rats, Sprague-Dawley
5.One hundred questions and answers about children′s sleep health in China
Zhifei XU ; Qin YANG ; Fan JIANG ; Xiaohong CAI ; Peiru XU ; Yuejie ZHENG ; Hanrong CHENG ; Yanrui JIANG ; Chenyi YU ; Kunling SHEN
Chinese Journal of Applied Clinical Pediatrics 2023;38(3):169-191
Good sleep is essential for children′s physical and mental health, growth, and development.Adequate and high-quality sleep positively impacts children′s quality of life, memory, learning, attention, mood, and behavior.Children of different ages have different sleep needs.Children have various sleep problems in different cultures.Therefore, it is significant to guide children to get healthy sleep by popularizing the sleep problems of Chinese children of all ages and in all dimensions.Based on China′s social and cultural background, this paper summarizes the contents related to children′s sleep physiology, good sleep habits, common sleep problems, sleep apnea disorders, hypnagogic sleep, narcolepsy, insomnia, and other issues that interfere with children′s sleep.Chinese sleep experts summarize and interpret the 100 sleep health problems of children that medical workers and parents are most concerned about.To promote children′s sleep health and popularize solutions to sleep problems.