Objective:To explore the factors affecting bone mineral density (BMD) in adult males with low-to-moderate fluoride exposure in Henan Province.Methods:Adult male villagers from low-to-moderate fluoride exposure areas in Tongxu County, Kaifeng City, Henan Province were recruited from April to May 2017 based on cluster random sampling. Questionnaire survey, physical measurements and urinary samples collection were conducted respectively. Urinary fluoride (UF) was determined by fluoride ion-selective electrode. Ultrasound bone densitometer was used to measure BMD (T-score). Partial correlation analysis and multiple linear regression were used to analyze the influence factors of BMD.Results:A total of 439 adult males were included in this study. Age, body mass index (BMI), UF content, and T-score of the participants were (47.99 ± 8.49) years, (25.77 ± 3.23) kg/m 2, (1.34 ± 0.74) mg/L, and-1.79 ± 0.79, respectively. Partial correlation analysis showed a significantly positive correlation between BMI and T-score after age adjustment ( r = 0.194, P < 0.05). Multiple linear regression showed that T-score decreased by 0.015 (95% CI:-0.024 -- 0.005, P < 0.05) for each 1-year increase in age and T-score increased by 0.034 (95% CI: 0.009-0.059, P < 0.05) for each 1.0 kg/m 2 increase in BMI. Interaction analysis showed that T-score was closely related to the interaction between overweight (≥24.0 kg/m 2), non-smoking, tea drinking and UF [ β (95% CI): 0.134 (0.001-0.269), 0.163 (- 0.015-0.337), 0.215 (- 0.006-0.436), P < 0.10]. Conclusions:Our findings reveal a negative correlation between age and BMD, and a positive correlation between BMI and BMD in adult males with low-to-moderate fluoride exposure in Henan Province. In addition, low-to-moderate fluoride exposure is more likely to damage the BMD of smokers.

Objective　To study the value of mean platelet volume/platelet ratio (MPV/PLT) in evaluating the severity and prognosis of acute cerebral infarction (ACI).Methods　One hundred and twenty-eight patients with ACI treated in our hospital from January 2019 to December 2020 were divided into mild group with NIHSS score (n=72) and moderate as well as severe group with NIHSS score>5 (n=56).The differences of clinical data between the two groups were compared.The prognosis was evaluated according to the modified Rankin Scale (mRS) at 3 months after discharge.mRS 0~3 was good prognosis and mRS 3~6 was poor prognosis.Results　The levels of MPV and MPV/PLT of ACI patients in moderate and severe group were higher than those of mild group (P<0.05).The levels of MPV and MPV/PLT of ACI patients with poor prognosis were higher than those in patients with good prognosis (P<0.05).By ROC curve analysis,MPV level and MPV/PLT level had evaluation value for the severity and prognosis of ACI patients.The sensitivity and specificity of MPV/PLT evaluation were better than MPV.Conclusion　MPV/PLT is valuable in evaluating the severity and prognosis of ACI patients.