Objective To understand the early experiences of acute ischemic stroke (AIS) patients after intravenous thrombolysis. Methods By purposive sampling method, and according to principle of sample saturation, semi-structure interview was conducted to inpatients who had undergone acute ischemic stroke and were treated with intravenous thrombolysis in Neurology Department in a comprehensive class Ⅲ grade A hospital in Shenzhen from March to September 2016. Colaizzi method was used for the analysis of interview content. Results Early experiences of acute ischemic stroke patients after intravenous thrombolysis can be concluded as four subjects: perceived body difference, heavy psychological burden, adaptation to new roles, and expectation of support from medical staff and family members. Conclusions For AIS patients, different experiences and needs appeared from the attack to the recovery period after thrombolysis, according to which, individualized nursing measures should be adopted by doctors and nurses.

Objective:To analyze the liver pathology, clinical characteristics and influence factors in patients with chronic hepatitis B virus (HBV) infection in immune tolerant phase (IT).Methods:The clinical data of 273 patients in IT phase who underwent liver biopsy from January 2015 to December 2019 were included in this study. The correlation between liver pathological changes and clinical features was analyzed.Results:There were 43 cases (15.75%) with liver histologic activity ≥ G2, 30 cases (10.99%) with liver fibrosis ≥ S2, and 55 cases (20.15%) with liver pathology ≥ G2 and/or ≥ S2. A total of 17.95% patients had liver steatosis. The majority (98.17%) of tissue samples were positive for HBsAg staining, while only 79.49% were positive for HBcAg. The characteristics of liver pathology were comparable in men from women patients. The differences of G and S were not statistically significant according to different HBsAg positivity, while those were statistically significant according to different HBcAg positivity. By univariate and multivariate analysis, the independent risk factors of pathological severity were HBcAg intensity, HBeAg level, and age. However, the differences of liver histologic activity and fibrosis were not statistically significant between those younger than 30 years old group from those older than 30 years old, neither between those younger or older than 40. Although the diagnostic value of liver inflammation and fibrosis 5 (LIF-5) was better than that of aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis 4 score (FIB-4), three diagnostic models for predicting the pathological severity were not strong enough (all area under the curves<0.8). Only the specificity of LIF-5 for predicting≥ G2, ≥ G2 and/or ≥ S2 was over 80%.Conclusions:Approximately 20% patients with chronic HBV infection in IT phase have progressive liver inflammation or fibrosis. The intensity of liver HBcAg and HBeAg level are negatively correlated with the severity of disease. The diagnostic models or most clinical indicators have low predictive effect for chronic HBV infections in IT phase.

Objective:To establish and evaluate a new diagnostic model for significant liver tissue damage in patients with chronic hepatitis B virus (HBV) infection in the immune tolerance phase.Methods:The clinical data of 275 chronic HBV infection patients in the immune tolerance phase who underwent liver biopsy from January 2015 to November 2020 in the Hwa Mei Hospital, University of Chinese Academy of Sciences were included. According to the liver pathological changes, patients were divided into

Objective:To compare and analyze the clinicopathological features and significance for indications of different types of antiviral therapy in chronic hepatitis B (CHB).Methods:Clinical data of 861 CHB cases who received liver biopsy, had hepatitis B virus (HBV) DNA-positive (> 30 IU/ml) and met the indications for antiviral therapy from January 2014 to December 2019 were included. Liver pathological changes and their correlation with clinical characteristics were compared and analyzed. According to different data, t-test, analysis of variance, nonparametric test, χ2 test, Ridit and logistic regression analysis were used for statistical analysis. Results:Most of the cases (72.24%) had remarkable pathological damage. The degree of liver fibrosis was higher in the normal than the abnormal group ( P<0.001). 17.54% cases had hepatic steatosis. The vast majority of cases (97.33%) had positive hepatitis B surface antigen (HBsAg), while only 50.87% had positive hepatitis B core antigen (HBcAg). The positive correlation factors affecting the severity of liver histopathology were alkaline phosphatase level, while the negative correlation factors were positive HBcAg staining, albumin and platelet level. The degree of liver inflammation and fibrosis had statistically significant differences with different HBcAg staining levels ( χ2=44.142 and 102.386, respectively; P<0.001), and the severity was more apparent in the negative group. Conclusion:There exist differences in clinicopathological features for indications of different types of antiviral therapy in patients with CHB. Liver function test range is inconsistent with degrees of hepatic histological severity. The positive and intensity of liver tissue HBcAg staining, and albumin and alanine aminotransferase levels have negative correlation with disease severity.

Objective To explore comprehensive nursing measures to the high-risk patients with cerebral apoplexy in nursing outpatient and evaluate the effect.Methods Convenience sampling method was used to select 75 high-risk cerebral apoplexy patients in the nursing outpatient from April 201 4 to December 201 4,patients were carried out comprehensive nursing measures including measuring blood pressure,body weight,and abdominal circumference,instructing to take medication correctly and establish a healthy physical exercise and diet style.Results After 6 months of intervention,systolic blood pressure and diastolic blood pressure of the subjects decreased from (1 48.40 ±1 3.86)mmHg to (1 33.1 ±1 2.49)mmHg and (84.75 ± 8.50)mmHg to (79.75 ±7.40)mmHg respectively(P <0.05).Before and after intervention,the reasonable exercise rate rose from 41 .3% to 72.9%,smoking rate decreased from 53.3% to 21 .4%,compliance with medication rose from 52.0% to 85.7%,salty diet rate decreased from 56.0% to 37.1 %,oiled diet rate decreased from 69.3% to 1 5.7%,compliance with fruit intake rose from 38.7% to 90.0%,compliance with milk drink rose from 30.7% to 75.7%(P <0.05).Conclusions Outpatient comprehensive stoke intervention measures to patients with high-risk for cerebral apoplexy can reduce the risk factors to stoke,improve lifestyle and provide basis for stoke high-risk population.