1.Cytosolic delivery of the immunological adjuvant Poly I:C and cytotoxic drug crystals
Xiaoqing DU ; Yuqi HOU ; Jia HUANG ; Yan PANG ; Chenlu RUAN ; Wei WU ; Chenjie XU ; Hongwei ZHANG ; Lifang YIN ; Wei HE
Acta Pharmaceutica Sinica B 2021;11(10):3272-3285
Co-delivery of chemotherapeutics and immunostimulant or chemoimmunotherapy is an emerging strategy in cancer therapy. The precise control of the targeting and release of agents is critical in this methodology. This article proposes the asynchronous release of the chemotherapeutic agents and immunostimulants to realize the synergistic effect between chemotherapy and immunotherapy. To obtain a proof-of-concept, a co-delivery system was prepared
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