Homeobox gene is an important gene family of developmental regulatory in the body.It is highly conserved in the evolutionary process.It is widely found in nervous,digestive,respiratory,circulatory,blood and genitourinary system,involved in rcgulating the growth and development of individuals,cells' proliferation,differentiation,apoptosis and other processes.The present studies show that the abnormal expressions of homeobox genes are closely related to the occurrence,development and prognosis of human multiple malignancies.In this paper,the research progress and prospect of the relationship between homeobox genes' family and development of digestive system tumors are reviewed.