OBJECTIVE: To explore the effect of septoplasty on the modality of inferior turbinate in patients with a deviated nasal septum. METHOD: Twenty-three patients with nasal septum deviation underwent septoplasty without turbinate surgery. All patients underwent CT imaging scans before and 3 months after the surgery. The thicknesses of the medial mucosa, lateral mucosa,and the cross-sectional areas of the inferior turbinate were measured and compared using the Wilcoxon signed rank test. P<0. 05 was considered statistically significant. RESULT: On the concave side of the septum, the thickness of the medial mucosa of the inferior turbinate was(5. 3+/-1.5) mm to (4. 1+/-1. 2) mm (P<0. 05), the thicknesses of the lateral mucosa of the inferior turbinate was(2. 5+/-0. 9) mm to (2.0+/-0. 9) mm (P>0. 05), and the cross-sectional area of the inferior turbinate was(139. 8 +/- 35.6) mm2 to( 110. 3 +/- 22.6)mm2 (P<0.05), pre- and post-operatively. On the convex side of the septum , the thickness of the medial mucosa of the inferior turbinate was(1.0 +/- 0. 6) mm to(4. 3 +/- 0. 6) mm (P>0. 05), the thicknesses of the lateral mucosa of the inferior turbinate was(1. 9+/-1. 1) mm to (1. 9+/-1.3) mm (P>0. 05), and the cross-sectional area of the inferior turbinate was(104. 5+/-15. 8)mm2 to(108. 3 +/- 20. 8)mm2 (P>0. 05), pre- and post-operatively. CONCLUSION The compensatory hypertrophic inferior turbinate may be self-adaptability in modality soon after septoplasty, thus surgeons must take it into consideration before performing turbinate surgery.
Adolescent ; Adult ; Female ; Humans ; Male ; Middle Aged ; Nasal Septum ; surgery ; Rhinoplasty ; Tomography, X-Ray Computed ; Turbinates ; diagnostic imaging ; Young Adult

【Objective】 To explore the role and mechanism of TRPC in promoting extracellular matrix (ECM) deposition in rat glomerular mesangial cells (HBZY-1). Methods Immunofluorescence staining was performed to observe the distribution and expression of TRPC1 and TRPC6 in HBZY-1 cells. After AngⅡ stimulation, qRT-PCR and Western blotting were used to detect the mRNA and protein expressions of Gαq/PLCβ4/TRPC signaling pathway main proteins and ECM deposition indicators (α-SMA, collagenⅢ and fibronectin). By silencing the expressions of TRPC1 and TRPC6 by RNA interference, the expressions of ECM deposition indicators were detected. Changes in [Ca²⁺]i influx were determined through Fluo-4AM Ca²⁺ imaging. 【Results】 Both TRPC1 and TRPC6 were expressed in HBZY-1, and were mainly located in cell membrane and cytoplasm. After AngⅡ stimulation, Gαq/PLCβ4/TRPC signaling pathway was activated, and the mRNA and protein expressions of Gαq, PLCβ4, TRPC1 and TRPC6 were all increased (P<0.05). [Ca²⁺]i influx also increased (P<0.01), and the mRNA and protein expressions of ECM deposition indicators (α-SMA, ColⅢ and Fn) were upregulated (P<0.05). Silencing the expressions of TRPC1 and TRPC6 by RNA interference led to decreased [Ca²⁺]i influx (P<0.05), and downregulated mRNA and protein expressions of ECM deposition indicators in HBZY-1 cells (P<0.05). The results suggested that inhibition of TRPC expressions could inhibit AngⅡ induced ECM deposition in HBZY-1 cells, which might be associated with decreased [Ca²⁺]i influx. 【Conclusion】 TRPC may be a novel therapeutic target of renal fibrosis.