Pazopanib is a multi-targeted tyrosine kinase inhibitor ,and is mainly used to treat renal cell carcinoma ,ovari-an cancer ,breast cancer ,and lung cancer .The researchers also found that pazopanib may cause diarrhea ,hypertension ,hair loss ,nausea ,and anorexia .This paper reviewed pazopanib clinical application and adverse reactions ,and provided a basis for this medication .

Objective To develop a UPLC-MS method for the determination of pazopanib in rat plasma, and study the pharmacokinetics of pazopanib in rats.Methods The effective UPLC MS/MS separation of the examined compounds was applied on an Acquity BEH C18 column with a gradient mobile phase system.AB Sciex QTRAP 5500 triple quadruple mass spectrometer equipped with an electrospray ionization (ESI) interface was used for mass spectrometric detection.The MRM transitions of m/z 438.3→357.2 and m/z 285.2→193.1 were used to quantify for pazopanib and ISTD, respectively;6 rats were given 80 mg/kg pazopanib intragastric administration.Blood samples were collected from the tail vein at different point after administration.The concentration of pazopanib in plasma was detected by the UPLC-MS methods.The pharmacokinetics parameters were analyzed by DAS program.Results Pazopanib and ISTD were eluted at 1.10 and 1.37 min respectively.Excellent liner relationship was obtained from the range of 0.25 μg/ml to 40.00 μg/ml (r=0.999 2).The intra-day RSD were 6.17%, 2.73% and 2.54% and inter-day RSD were 7.56%, 5.98% and 2.84% respectively at three concentrations (0.50, 10.00, 30.00 μg/ml), the recoveries were (78.4±4.8)%, (85.9±3.5)% and (81.1±4.2)% respectively, the Matrix effect were (106.7±5.3) %, (101.3±6.7) % and (97.6±4.4) % respectively at three concentrations (0.50, 10.00, 30.00 μg/ml);6 rats were given 80 mg/kg pazopanib intra-gastric administration.The main pharmacokinetics parameters of pazopanib were as following: cmax (20.22±1.95) μg/ml,tmax (1.75±0.76) h,t1/2 (7.35±2.31) h,AUC0-t (213.16±39.92) μg·h/L,AUC0-∞ (215.79±39.84) μg·h/L,Vd (4.10±1.78) L/kg,CL (0.38±0.07) L/h.Conclusion The method was simple, rapid, accurately,which could be used to determine the pazopanib concentration in rat plasma and study on its pharmacokinetics.Pazopanib was fitted to the first-order elimination kinetics in rats.

Objective In order to test and improve the monitoring technical level and ability of radiation environmental monitoring network in Zhejiang Province, ensure the accuracy and reliability of monitoring data and information, and obtain the cosmic ray response values of instruments and equipment in this year. Methods In September 2018，an intercomparison meeting of environmental gamma radiation air absorbed dose rate within the radiation environmental monitoring network of Zhejiang province was held in Ningbo，which was organized by Zhejiang Province Radiation Environmental Monitoring Center.A total of 33 sets of instruments from 15 member units participated in the intercomparison measurements at 5 environmental measuring points, and the comparison results were evaluated by the Z score values. Results It was found that the |Z| of all measurement results were less than or equal to 2, and the evaluation results were satisfactory and acceptable. Conclusion The measured data of scintillation counters have relatively wider dispersion，and the high pressure ionization chambers have bigger response valuetocosmic ray. The measurement results of the two kinds of instruments keep a good linearity except for the measurement points of cosmic ray response.