Objective To analyse the clincal and electroencephalographic characteristics of temporal lobe epilepsy(TLE).Methods Totally 145 patinets with TLE were included in our study.The clinical data,electroencephalographic and neuroimaging investigations were described in detail.Results The kinds of temporal lobe seizures included simple partial,complex partial and generalized tonic clonic.Complex partial seizure was the most common one.The main etiological factors related to 45 patients with lesional TLE were cerebrovascular disease,intracranial infection and trauma etc.Twenty-nine patients had hippocampal sclerosis in the non-lesional TLE group.The electroencephalography recording for TLE showed the presence of interictal epileptic paroxysms discharges over the temporal areas.Conclusion TLE is a syndrome with a variety of clinical manifestations and etiology.Comprehensive diagnosis and therapy are crucial in clinical practice.

Objective To determine the ultrastructural localization of MDR1 and GFAP in the surgically resected brain tissues from intractable epilepsy patients. Methods Expression of MDR1 and GFAP in brain tissues was examined by using PAG immunolabeling technique for electron microscopy. Results The MDR1 and GFAP labeled by gold particles were only detected at some reactive astrocytes. The positive gold particles were mainly located in the astrocytic cytoplasm and their membrane, but not in the nucleus.Conclusion The expression of MDR1 and GFAP in the brain of patients with clinically intractable epilepsy were mainly located at the cytoplasm and membrane of certain reactive astrocytics.;

0.05) in sex,attack frequency,cause of disease,MRI and EEG among 202 patients. The TCM syndrome of weak in spleen and phlegm excess was the main type of child patients,while deficiency in liver and kidney was common in middle-aged and old patients,and they had prominent statistical significance (P 0.05) in sex,attack frequency,cause of disease,MRI and EEG. The weak in spleen and phlegm excess type is common in children,and the deficiency in liver and kidney type is usual in middle-aged and the elderly. Long disease course manifests deficiency or deficiency mixed with excess syndromes,while short course mainly shows excess syndromes. Earlier age of onset manifests deficiency or deficiency mixed with excess syndromes,and onset in youth and middle age often show excess syndromes. Discharge location in temporal lobe is often of wind phlegm type,while discharge location in frontal lobe often belongs to phlegm fire disturbing upper body type. Weak in spleen and phlegm excess type often can be seen in general discharge.

Objective:This study aimed to develop a Chinese version of Quality of life in Epilepsy Inventory(QOLIE-89) and to confirm its psychometric properties.Methods:The original English version QOLIE-89 was adapted to Chinese language through a translation back-translation procedure. The assessment included 204 patients with epilepsy .The test-retest and internal consistency reliabilities, criterion validity and discriminative validity were assessed.Results:The test-retest reliability (Pearson's correlation coefficient) for Chinese version QOLIE-89 was 0.63-0.95 and internal consistency reliability (Cronbach's alpha) was 0.76-0.92. The confirmatory factor analysis indicated that the Chinese version of QOLIE-89 was composed of three dimensions(CMIN/DF=2.17,GFI=0.98, AGFI=0.90, CFI=0.98,RMSEA=0.061), which were physiology, psychology and social function that including 17 factors obtained by exploration analysis ,which can explained 71.91% of total variance. Spearman's rank correlations between Chinese version QOLIE-89 total score and QOLIE-31 total score was 0.96 and domain scores were from 0.86-1.00.QOLIE-89 items could be discriminated well between patients according to epileptic seizures severity and antiepileptic drug side effects.Conclusion:The psychometric properties of the Chinese version QOLIE-89 inventory are fairly good and similar to the American version and can be applied to assess quality of life for adult patients with epilepsy in China.

Objective To retrospectively conclude the characteristics of interictal EEG of patients with intractable epilepsy, and then analyze their relationship with postoperative seizures. Methods 168 patients with intractable epilepsy in the epilepsy center of Beijing Tiantan Hospital that underwent strictly preoperative evaluations before surgery were collected and followed up for 2 and 5 years, the characteristics of their interictal EEG and postoperative seizures after 2 years and 5 years were concluded and analyzed. Results There was no significant difference between 2 years and 5 years postoperative seizures in 73 intractable epilepsy patients (P>0.05). There was statistically differences in postoperative seizures between unilateral and bilateral abnormal discharges (P<0.05). Conclusion Patients with unilateral abnormal discharges and located at temporal in interictal EEG predict better outcomes 2 years after operation.

Objective To explore the various types of progressive myoclonus epilepsy seizure characteristics, diagnostic strategies, and pathological features.Methods12 cases of progressive myoclonus epilepsy were analyzed with the clinical characteristics, the routine laboratory examinations, the pathological examination by light and electron microscopy to extra cranial.Results12 cases carried out routine examinations, neural electrophysiological examinations and physical examinations. The result showed that there 5 patients diagnosed with Neuronal Ceroid Lipofuscinoses, 5 patients with MERRF, 1 patient with Lafora Disease, 1 patient with Unverricht-Lundborg disease.ConclusionProgressive myoclonus epilepsy is a group of rare myoclonus epilepsy syndrome. It can be early diagnosed and properly classified with detailed medical history, characteristics of the EEG, and physical examination of extra cranial tissue, especially electron microscopy examination.

ObjectiveTo evaluate the effect of interventional chemotherapy (ICT)on the expression of vascular endothelial growth factor(VEGF) and microvessel density (MVD) in rectal carcinoma.MethodsThe expression of VEGF and MVD in 34 patients of rectal cancer were determined before the ICT and 4～5 weeks after the ICT. ResultsBefore the ICT and 4～5 week after the ICT, the expressions of VEGF in the tissue of rectal cancer was 61.8%(21/34) and 32.3%(11/34) respectively(P