60 years old). 43 cases of antiepileptic drugs combination accounted for 10% and the therapeutic plasma concentration of 27 cases deviated from normal range(62.8%). CONCLUSION:Results of plasma concentration monitoring provide an important basis for clinical drug use. Monitoring data and other clinical index can promote rational use of antiepileptic drugs.

Objective To assess the effect of micro-orthics teaching based on the online micro-teaching. Methods 116 students were randomly divided into test group and control group. With same clin-ical orthopedic teaching content, the "micro-course" network teaching mode and traditional teaching mode were adopted respectively. After the clinical internship, the two groups of students were assessed both in theoretical knowledge and clinical skills and self-designed questionnaire was carried out. The test results were analyzed by t-test and Spearman rank correlation method through SPSS 23.0 data analysis. Results The theoretical scores of students in two groups after online micro-teaching were compared with a t value of-3.976 and a P value of 0.000. The clinical skill assessment scores were compared with a t value of-5.999 and a P value of 0.000, indicating that the theoretical scores of the test group, especially the clinical skills assessment scores were significant higher than that of the control group (P<0.05). In the questionnaire survey results, for the understanding of the following five items, "effectiveness of teaching methods, promotion of interaction between teachers and students, promotion of clinical learning, systematic establishment of clini-cal thinking, and deepening understanding of theoretical knowledge", the test group's satisfaction rate was obviously higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusions The "micro-course" online teaching model significantly improves the clinical teaching quality of micro orthopaedics and promotes students' autonomy and enthusiasm in learing. However, it is still neces-sary to further develop and improve the micro-curricular teaching and interactive system to achieve more systematic and long-lasting teaching effects.

By hemodynamic monitoring of liver transplantation with Color Doppler ultrasound, we observed the hemodynamic changes pre- and post-operatively and the patency of the anastomotic vessels, to detect or exclude the presence of complications, then assess the prognosis. We measured the hepatic blood flow after orthotopic liver transplantation in recent 6 cases, and observed the patency of anastomostic vessels and the hemodynamic improvement of the portal vein and hepatic arteries. The abnormal liquid and solid echoes were not found around the transplantated liver in all 6 cases. The echoes of hepatic parenchyma and tububes were normal. The direction and speed of blood flow were also normal. Five of anastomoses of portal vein in 6 cases were patent. The rest one was a little stenosed, and the speed of local blood flow was a little faster. There were 11 patent ones and 1 mildly stenosed in the 12 anastomoses of inferior venae cavae. The speed index(SI) and resistance index(RI) of hepatic arterial blood flow distal to the anastomoses were all normal. Liver transplantation is the redical therapying of portal hypertension, and the color Doppler ultrasound is the best non-invasived method for monitoring the hemodynamic changes of transplantated liver.
Adult ; Female ; Humans ; Liver ; diagnostic imaging ; physiology ; Liver Circulation ; Liver Transplantation ; diagnostic imaging ; Male ; Middle Aged ; Monitoring, Physiologic ; Ultrasonography, Doppler, Color ; Vascular Patency

Hallux valgus is one of the common diseases in foot and ankle surgery, mainly manifested as hallux toe valgus, first metatarsal adduction and first metatarsophalangeal joint dislocation or subluxation, resulting in a series of pathological changes. There are more than 200 surgical methods, and osteotomy can only be performed empirically, which is a great challenge for most doctors. The physical model generated by 3D printing technology can intuitively see the specific shape of the patient′s heel toes, and can make better preoperative planning through the model, which provides a better choice and method for the surgical method of hallux valgus and the design of intraoperative guide plate. With the rapid development of minimally invasive technology, the treatment of hallux valgus has also been greatly improved. This article mainly reviews the diagnosis and treatment of hallux valgus and the application progress of 3D printing.