1.Effect of high-flux hemodialysis on immune state in maintenance hemodialysis patients
Zhorg LI ; Chengsheng HUANG ; Min XU ; Li YIN ; Ting LIU ; Qing ZHANG
Chinese Journal of Postgraduates of Medicine 2011;34(25):10-13
ObjectiveTo study the changes of serum immune state in maintenance hemodialysis (MHD) patients with high-flux hemodialysis. MethodsSixty MHD patients were divided into high-flux hemodialysis group (group T, 30 cases, receiving high-flux hemodialysis, 3 times per week and routine drug therapy) and conventional dialysis group (group C, 30 cases, taking conventional dialysis, 3 times per week and routine drug therapy) by random number table. They were treated for 12 weeks. Serum IgG,IgA, IgM,C3, C4, T lymphocyte subsets and albumin, prealbumin, hemoglobin were detected at the experiment onset and 12 weeks later, and compared with those of 20 normal medical examination adults (group N ), meanwhile the ratio of infection was calculated. ResultsThe levels of IgG,IgA,IgM,C3,C4,CD3+,CD4+,CD4+/CD/8+ in group C had no significant changes before and after treatment (P > 0.05 ), but there were significant changes in group T[(12.20 ± 3.98) g/L vs.(6.18± 1.45) g/L, (1.89 ±0.58) g/L vs. (0.63 ±0.15) g/L, (1.29 ± 0.47)g/L vs. (0.51 ± 0.13) g/L, (0.94 ± 0.36) g/L vs.(0.58 ± 0.20) g/L, (0.28 ± 0.06) g/L vs. (0.11 ± 0.04) g/L,(63.11 ± 9.43 )% vs. (53.26 ± 9.08 )%, ( 38.21 ± 6.15 )% vs. ( 31.56± 6.02 )%, 1.48 ± 0.37 vs. 1.25 ± 0.43](P< 0.05), and there were significant differences between group T and group C after treatment (P< 0.05).The ratio of infection in group T was decreased obviously [46.7% (14/30) vs. 133.3% (40/30), P < 0.05], but there was no significant difference in group C [126.7%(38/30) vs. 136.7%(41/30),P> 0.05]. Conclusion High-flux hemodialysis can improve the immune state and the nuuitional state in MHD patients, and it could decrease the infection rate.
2.Consistency of TEE technique and PAC method in monitoring cardiac volume load and cardiac hemodynamic changes
Chengsheng XU ; Zhaoxia JIN ; Zhifang WANG ; Bin XIE ; Baoyun LI ; Huoping LI ; Liansheng WANG
Chinese Journal of cardiovascular Rehabilitation Medicine 2017;26(3):328-331
Objective: To evaluate the consistency of transesophageal echocardiography (TEE) and pulmonary artery catheter (PAC) method in monitoring cardiac volume load and cardiac hemodynamic indexes.Methods: A total of 45 patients undergoing coronary artery bypass grafting in our hospital were selected.The right ventricular end-diastolic volume (RVEDV), right ventricular end-systolic volume (RVESV) and right ventricular ejection fraction (RVEF) were monitored during surgery by TEE and PAC respectively.Consistency of monitored data was compared between two methods.Results: Both TEE and PAC indicated that compared with baseline level, after loading, there were significant rise in RVEDV [TEE: (38±6)ml vs.(51±9ml), PAC: (153±17)ml vs.(188±19)ml], RVESV [TEE: (19±4)ml vs.(33±5)ml, PAC: (92±16)ml vs.(110±23)ml], P<0.01 all, but there was no significant change in RVEF, P>0.05.Before therapy, RVEDV, RVESV and RVEF monitored by PAC and TEE showed significant positive correlation, and all relevant coefficients were >0.8 (r=0.844, 0.862, 0.916, P<0.01 all);after therapy, correlation of RVEDV and RVESV significantly reduced to <0.6 (r=0.552, 0.579, P<0.05 both), but RVEF correlation remained >0.8 (r=0.892, P<0.01).Conclusion: In clinical monitor, the consistency of TEE and PAC is high,the former is non-traumatic,and is more convenient for clinical use.
3.A unified deep-learning network to accurately segment insulin granules of different animal models imaged under different electron microscopy methodologies.
Xiaoya ZHANG ; Xiaohong PENG ; Chengsheng HAN ; Wenzhen ZHU ; Lisi WEI ; Yulin ZHANG ; Yi WANG ; Xiuqin ZHANG ; Hao TANG ; Jianshe ZHANG ; Xiaojun XU ; Fengping FENG ; Yanhong XUE ; Erlin YAO ; Guangming TAN ; Tao XU ; Liangyi CHEN
Protein & Cell 2019;10(4):306-311