1.Educational reform of dispensing Chinese herbs
Jing LIN ; Chengmei MA ; Jing ZHANG ; Mei LI ; Xueqin YU
International Journal of Traditional Chinese Medicine 2017;39(3):258-260
This paper explored the educational reform of dispensing Chinese drugherbs. The education reform included implementing the project of teaching methods, implementing modern experimental methods, cultivating comprehensive quality of students, training students' creative thinking, and stimulating the initiative of students. All these strategies could improve the quality of teaching and make students' comprehensive abilities meet the demand.
2.Dendrocalamus latiflorus and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production via AKT activation.
Kun LUO ; Wenting HUANG ; Liansheng QIAO ; Xiaoling ZHANG ; Di YAN ; Zhiyu NING ; Chengmei MA ; Honglei DANG ; Dong WANG ; Hongyan GUO ; Lan XIE ; Jing CHENG
Acta Pharmaceutica Sinica B 2022;12(5):2239-2251
The potential medicinal value of Ma bamboo (Dendrocalamus latiflorus), one of the most popular and economically important bamboo species in China, has been underestimated. In the present study, we found that D. latiflorus leaf extract (DLE) reduced fasting blood glucose levels, body weight, and low-density lipoprotein cholesterol with low liver toxicity in db/db mice. In addition, gene expression profiling was performed and pathway enrichment analysis showed that DLE affected metabolic pathways. Importantly, DLE activated the AKT signaling pathway and reduced glucose production by downregulating glucose-6-phosphatase (G6PC) and phosphoenolpyruvate carboxykinase 1 (PCK1) expression. Moreover, network pharmacology analysis identified rutin as an active component in DLE through targeting insulin growth factor 1 receptor (IGF1R), an upstream signaling transducer of AKT. Due to its hypoglycemic effects and low toxicity, DLE may be considered an adjuvant treatment option for type 2 diabetes patients.