OBJECTIVETo study the relationship between glutathione S transferase M1(GST mu) gene deletion and leukemia in workers exposed to benzene.

METHODSA matched population-based case-control survey with multivariate Logistic regression analysis was conducted in this study.

RESULTSIn the population of 34 patients and their matched controls, the absence of the GST mu genotype conferred odds ratio of 3.6. It suggested that GST mu was an important determinant of heterogeneity in individual susceptibility to leukemia associated with exposure to benzene. The single-variance analysis indicated that these markedly significant factors were GST mu gene deletion, GST mu isoenzyme activity, duration of exposure, GST isoenzyme activity, smoking quantity and average concentration of benzene in workshop air. The multivariate analysis indicated that these markedly significant factors were GST mu gene deletion, duration of exposure to benzene and GST mu isoenzyme activity.

CONCLUSIONGST mu gene deletion may be associated with increased risk of leukemia in workers exposed to benzene and is one of genetically determined factors.

Benzene ; toxicity ; Case-Control Studies ; Gene Deletion ; Glutathione Transferase ; genetics ; Humans ; Leukemia ; enzymology ; etiology ; genetics ; Logistic Models ; Multivariate Analysis ; Occupational Exposure ; adverse effects

OBJECTIVETo study the relationship between occupational stress and psychological health state among oil workers.

METHODS1,230 oil workers in 122 work types of oil industry were selected and written occupational stress questionary(OSQ) and symptom check list (SCL-90).

RESULTSPetroleum workers' psychological health states were poor with increasing occupational stress degree. The scores in physical symptoms(1.87 +/- 0.80, 1.72 +/- 0.70), depression(1.74 +/- 0.76, 1.62 +/- 0.67), horror(1.48 +/- 0.65, 1.39 +/- 0.55) in the high and medium stress group were obviously higher than those in low stress group(1.55 +/- 0.61, 1.43 +/- 0.54, 1.28 +/- 0.46, respectively, P < 0.05). The score of mood state in the high and medium stress group was obviously higher than that in low stress group(P < 0.05). Psychological health states and mood state in the petroleum workers with short service length are significantly poorer than that with long service length(P < 0.01).

CONCLUSIONOccupational stress should affect psychological health state of petroleum workers.

Affect ; Humans ; Mental Health ; Occupational Diseases ; psychology ; Petroleum ; Stress, Psychological ; psychology